| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Purified pig brain Ca
Volume 270,
Number 29,
Issue of July 21, pp. 17616-17621, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
-Calmodulin-dependent Protein Kinase IV by
Ca
-Calmodulin-dependent Protein Kinase Ia Kinase
PHOSPHORYLATION OF THREONINE 196 IS ESSENTIAL FOR ACTIVATION
-calmodulin
(CaM)-dependent protein kinase Ia kinase (Lee, J. C., and Edelman, A.
M.(1994) J. Biol. Chem. 269, 2158-2164) enhances, by up
to 24-fold, the activity of recombinant CaM kinase IV in a reaction
also requiring Ca
-CaM and MgATP. The addition of
brain extract, although capable of activating CaM kinase IV by itself,
provides no further activation beyond that induced by purified CaM
kinase Ia kinase, consistent with the lack of a requirement of
additional components for activation. Activation is accompanied by the
development of significant (38%) Ca
-CaM-independent
CaM kinase IV activity. In parallel fashion to its activation, CaM
kinase IV is phosphorylated in a CaM kinase Ia kinase-,
Ca
-CaM-, and MgATP-dependent manner. Phosphorylation
occurs on multiple serine and threonine residues with a Ser-P:Thr-P
ratio of
3:1. The identical requirements for phosphorylation and
activation and a linear relationship between extent of phosphorylation
of CaM kinase IV and its activation state indicate that CaM kinase IV
activation is induced by its phosphorylation. Replacement of Thr-196 of
CaM kinase IV with a nonphosphorylatable alanine by site-directed
mutagenesis abolishes both the phosphorylation and activation of CaM
kinase IV, demonstrating that Thr-196 phosphorylation is essential for
activation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Tai, S. Feng, R. Ge, W. Du, X. Zhang, Z. He, and Y. Wang TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway J. Cell Sci., July 15, 2008; 121(14): 2301 - 2307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tenbrock, Y.-T. Juang, V. C. Kyttaris, and G. C. Tsokos Altered signal transduction in SLE T cells Rheumatology, October 1, 2007; 46(10): 1525 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Rubenstein and M. C. Schmidt Mechanisms Regulating the Protein Kinases of Saccharomyces cerevisiae Eukaryot. Cell, April 1, 2007; 6(4): 571 - 583. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Blaeser, M. J. Sanders, N. Truong, S. Ko, L. J. Wu, D. F. Wozniak, M. S. Fanselow, M. Zhuo, and T. A. Chatila Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca2+/Calmodulin Kinase Kinase {alpha}-Deficient Mice Mol. Cell. Biol., December 1, 2006; 26(23): 9105 - 9115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Hurley, K. A. Anderson, J. M. Franzone, B. E. Kemp, A. R. Means, and L. A. Witters The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases J. Biol. Chem., August 12, 2005; 280(32): 29060 - 29066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Verploegen, L. Ulfman, H. W. M. van Deutekom, C. van Aalst, H. Honing, J.-W. J. Lammers, L. Koenderman, and P. J. Coffer Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function Blood, August 1, 2005; 106(3): 1076 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Chow, K. A. Anderson, P. K. Noeldner, and A. R. Means The Autonomous Activity of Calcium/Calmodulin-dependent Protein Kinase IV Is Required for Its Role in Transcription J. Biol. Chem., May 27, 2005; 280(21): 20530 - 20538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Li and K. U. Malik Angiotensin II-induced Akt activation is mediated by metabolites of arachidonic acid generated by CaMKII-stimulated Ca2+-dependent phospholipase A2 Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2306 - H2316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lee, G. Q. Butcher, K. R. Hoyt, S. Impey, and K. Obrietan Activity-Dependent Neuroprotection and cAMP Response Element-Binding Protein (CREB): Kinase Coupling, Stimulus Intensity, and Temporal Regulation of CREB Phosphorylation at Serine 133 J. Neurosci., February 2, 2005; 25(5): 1137 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Davare, T. Saneyoshi, E. S. Guire, S. C. Nygaard, and T. R. Soderling Inhibition of Calcium/Calmodulin-dependent Protein Kinase Kinase by Protein 14-3-3 J. Biol. Chem., December 10, 2004; 279(50): 52191 - 52199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Howe, M. M. LaHair, J. A. McCubrey, and R. A. Franklin Redox Regulation of the Calcium/Calmodulin-dependent Protein Kinases J. Biol. Chem., October 22, 2004; 279(43): 44573 - 44581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tokumitsu, N. Hatano, H. Inuzuka, S. Yokokura, N. Nozaki, and R. Kobayashi Mechanism of the Generation of Autonomous Activity of Ca2+/Calmodulin-dependent Protein Kinase IV J. Biol. Chem., September 24, 2004; 279(39): 40296 - 40302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Anderson, P. K. Noeldner, K. Reece, B. E. Wadzinski, and A. R. Means Regulation and Function of the Calcium/Calmodulin-dependent Protein Kinase IV/Protein Serine/Threonine Phosphatase 2A Signaling Complex J. Biol. Chem., July 23, 2004; 279(30): 31708 - 31716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Bradshaw, A. Hudmon, and H. Schulman Chemical Quenched Flow Kinetic Studies Indicate an Intraholoenzyme Autophosphorylation Mechanism for Ca2+/Calmodulin-dependent Protein Kinase II J. Biol. Chem., May 31, 2002; 277(23): 20991 - 20998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tokumitsu, H. Inuzuka, Y. Ishikawa, M. Ikeda, I. Saji, and R. Kobayashi STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase J. Biol. Chem., May 3, 2002; 277(18): 15813 - 15818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Shohat, T. Spivak-Kroizman, O. Cohen, S. Bialik, G. Shani, H. Berrisi, M. Eisenstein, and A. Kimchi The Pro-apoptotic Function of Death-associated Protein Kinase Is Controlled by a Unique Inhibitory Autophosphorylation-based Mechanism J. Biol. Chem., December 7, 2001; 276(50): 47460 - 47467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Verploegen, J.-W. J. Lammers, L. Koenderman, and P. J. Coffer Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent kinase Blood, November 1, 2000; 96(9): 3215 - 3223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Means Regulatory Cascades Involving Calmodulin-Dependent Protein Kinases Mol. Endocrinol., January 1, 2000; 14(1): 4 - 13. [Full Text]
|
|
|
|
|
|
K. Eto, N. Takahashi, Y. Kimura, Y. Masuho, K.-i. Arai, M.-a. Muramatsu, and H. Tokumitsu Ca2+/Calmodulin-dependent Protein Kinase Cascade in Caenorhabditis elegans. IMPLICATION IN TRANSCRIPTIONAL ACTIVATION J. Biol. Chem., August 6, 1999; 274(32): 22556 - 22562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Hook, B. E. Kemp, and A. R. Means Peptide Specificity Determinants at P-7 and P-6 Enhance the Catalytic Efficiency of Ca2+/Calmodulin-dependent Protein Kinase I in the Absence of Activation Loop Phosphorylation J. Biol. Chem., July 16, 1999; 274(29): 20215 - 20222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tokumitsu, N. Takahashi, K. Eto, S. Yano, T. R. Soderling, and M.-a. Muramatsu Substrate Recognition by Ca2+/Calmodulin-dependent Protein Kinase Kinase. ROLE OF THE ARG-PRO-RICH INSERT DOMAIN J. Biol. Chem., May 28, 1999; 274(22): 15803 - 15810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsushita and A. C. Nairn Inhibition of the Ca2+/Calmodulin-dependent Protein Kinase I Cascade by cAMP-dependent Protein Kinase J. Biol. Chem., April 9, 1999; 274(15): 10086 - 10093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kasahara, K. Fukunaga, and E. Miyamoto Differential Effects of a Calcineurin Inhibitor on Glutamate-induced Phosphorylation of Ca2+/Calmodulin-dependent Protein Kinases in Cultured Rat Hippocampal Neurons J. Biol. Chem., March 26, 1999; 274(13): 9061 - 9067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Anderson, R. L. Means, Q.-H. Huang, B. E. Kemp, E. G. Goldstein, M. A. Selbert, A. M. Edelman, R. T. Fremeau, and A. R. Means Components of a Calmodulin-dependent Protein Kinase Cascade. MOLECULAR CLONING, FUNCTIONAL CHARACTERIZATION AND CELLULAR LOCALIZATION OF Ca2+/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE beta J. Biol. Chem., November 27, 1998; 273(48): 31880 - 31889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsushita and A. C. Nairn Characterization of the Mechanism of Regulation of Ca2+/ Calmodulin-dependent Protein Kinase I by Calmodulin and by Ca2+/Calmodulin-dependent Protein Kinase Kinase J. Biol. Chem., August 21, 1998; 273(34): 21473 - 21481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. McGinnis, M. M. Whitton, M. E. Gnegy, and K. K. W. Wang Calcium/Calmodulin-dependent Protein Kinase IV Is Cleaved by Caspase-3 and Calpain in SH-SY5Y Human Neuroblastoma Cells Undergoing Apoptosis J. Biol. Chem., August 7, 1998; 273(32): 19993 - 20000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Heist, M. Srinivasan, and H. Schulman Phosphorylation at the Nuclear Localization Signal of Ca2+/Calmodulin-dependent Protein Kinase II Blocks Its Nuclear Targeting J. Biol. Chem., July 31, 1998; 273(31): 19763 - 19771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Westphal, K. A. Anderson, A. R. Means, and B. E. Wadzinski A Signaling Complex of Ca2+-Calmodulin-Dependent Protein Kinase IV and Protein Phosphatase 2A Science, May 22, 1998; 280(5367): 1258 - 1261. [Abstract] [Full Text]
|
|
|
|
|
|
R. D. Cauthron, K. B. Carter, S. Liauw, and R. A. Steinberg Physiological Phosphorylation of Protein Kinase A at Thr-197 Is by a Protein Kinase A Kinase Mol. Cell. Biol., March 1, 1998; 18(3): 1416 - 1423. [Abstract] [Full Text]
|
|
|
|
|
|
S. I. Gringhuis, L. F. M. H. de Leij, P. J. Coffer, and E. Vellenga Signaling through CD5 Activates a Pathway Involving Phosphatidylinositol 3-Kinase, Vav, and Rac1 in Human Mature T Lymphocytes Mol. Cell. Biol., March 1, 1998; 18(3): 1725 - 1735. [Abstract] [Full Text]
|
|
|
|
|
|
R. R. White, Y.-G. Kwon, M. Taing, D. S. Lawrence, and A. M. Edelman Definition of Optimal Substrate Recognition Motifs of Ca2+-Calmodulin-dependent Protein Kinases IV and II Reveals Shared and Distinctive Features J. Biol. Chem., February 6, 1998; 273(6): 3166 - 3172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Naito, Y. Watanabe, H. Yokokura, R. Sugita, M. Nishio, and H. Hidaka Isoform-specific Activation and Structural Diversity of Calmodulin Kinase I J. Biol. Chem., December 19, 1997; 272(51): 32704 - 32708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. I. Gringhuis, L. F. M. H. de Leij, G. A. Wayman, H. Tokumitsu, and E. Vellenga The Ca2+/Calmodulin-dependent Kinase Type IV Is Involved in the CD5-mediated Signaling Pathway in Human T Lymphocytes J. Biol. Chem., December 12, 1997; 272(50): 31809 - 31820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Wayman, H. Tokumitsu, and T. R. Soderling Inhibitory Cross-talk by cAMP Kinase on the Calmodulin-dependent Protein Kinase Cascade J. Biol. Chem., June 27, 1997; 272(26): 16073 - 16076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Anderson, T. J. Ribar, M. Illario, and A. R. Means Defective Survival and Activation of Thymocytes in Transgenic Mice Expressing a Catalytically Inactive Form of Ca2+/Calmodulin-Dependent Protein Kinase IV Mol. Endocrinol., June 1, 1997; 11(6): 725 - 737. [Abstract] [Full Text]
|
|
|
|
|
|
S. A. Hawley, M. Davison, A. Woods, S. P. Davies, R. K. Beri, D. Carling, and D. G. Hardie Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase J. Biol. Chem., November 1, 1996; 271(44): 27879 - 27887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chatila, K. A. Anderson, N. Ho, and A. R. Means A Unique Phosphorylation-dependent Mechanism for the Activation of Ca2+/Calmodulin-dependent Protein Kinase Type IV/GR J. Biol. Chem., August 30, 1996; 271(35): 21542 - 21548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Aletta, M. A. Selbert, A. C. Nairn, and A. M. Edelman Activation of a Calcium-Calmodulin-dependent Protein Kinase I Cascade in PC12 Cells J. Biol. Chem., August 23, 1996; 271(34): 20930 - 20934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Krebs, R. L. Means, and P. Honegger Induction of Calmodulin Kinase IV by the Thyroid Hormone during the Development of Rat Brain J. Biol. Chem., May 10, 1996; 271(19): 11055 - 11058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Edelman, K. I. Mitchelhill, M. A. Selbert, K. A. Anderson, S. S. Hook, D. Stapleton, E. G. Goldstein, A. R. Means, and B. E. Kemp Multiple Ca[IMAGE]-Calmodulin-dependent Protein Kinase Kinases from Rat Brain J. Biol. Chem., May 3, 1996; 271(18): 10806 - 10810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Watanabe, S. Okuno, T. Kitani, and H. Fujisawa Inactivation of Calmodulin-dependent Protein Kinase IV by Autophosphorylation of Serine 332 within the Putative Calmodulin-binding Domain J. Biol. Chem., March 22, 1996; 271(12): 6903 - 6910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tokumitsu and T. R. Soderling Requirements for Calcium and Calmodulin in the Calmodulin Kinase Activation Cascade J. Biol. Chem., March 8, 1996; 271(10): 5617 - 5622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Sun, R. L. Means, B. LeMagueresse, and A. R. Means Organization and Analysis of the Complete Rat Calmodulin- dependent Protein Kinase IV Gene J. Biol. Chem., December 8, 1995; 270(49): 29507 - 29514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Hawley, M. A. Selbert, E. G. Goldstein, A. M. Edelman, D. Carling, and D. G. Hardie 5`-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca[IMAGE]/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms J. Biol. Chem., November 10, 1995; 270(45): 27186 - 27191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tokumitsu, M.-a. Muramatsu, M. Ikura, and R. Kobayashi Regulatory Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase J. Biol. Chem., June 23, 2000; 275(26): 20090 - 20095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Joseph and A. R. Means Identification and Characterization of Two Ca2+/CaM-dependent Protein Kinases Required for Normal Nuclear Division in Aspergillus nidulans J. Biol. Chem., December 1, 2000; 275(49): 38230 - 38238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-S. Hsu, G.-D. Chen, L.-S. Lee, C.-W. Chi, J.-F. Cheng, and J.-Y. Chen Human Ca2+/Calmodulin-dependent Protein Kinase Kinase beta Gene Encodes Multiple Isoforms That Display Distinct Kinase Activity J. Biol. Chem., August 10, 2001; 276(33): 31113 - 31123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kasahara, K. Fukunaga, and E. Miyamoto Activation of Calcium/Calmodulin-dependent Protein Kinase IV in Long Term Potentiation in the Rat Hippocampal CA1 Region J. Biol. Chem., June 22, 2001; 276(26): 24044 - 24050. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
