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(Received for publication, May 22, 1995; and in revised form, June 1, 1995) From the A homogeneous oligonucleosome complex was prepared by
reconstitution of highly hyperacetylated histone octamers onto a linear
DNA template consisting of 12 tandemly arranged 208-base pair fragments
of the 5 S rRNA gene from the sea urchin Lytechinus
variegatus. The ionic strength-dependent folding of this
oligonucleosome assembly was monitored by sedimentation velocity and
electron microscopy. Both types of analysis indicate that under ionic
conditions resembling those found in the physiological range and in the
absence of histone H1, the acetylated oligonucleosome complexes remain
in an extended conformation in contrast to their nonacetylated
counterparts. The implications of this finding in the context of a
multistate model of chromatin folding (Hansen, J. C., and Ausio,
J.(1992) TIBS 197, 187-191) as well as its biological
relevance are discussed.
Volume 270,
Number 30,
Issue of July 28, pp. 17923-17928, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
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