JBC Origene Your Gene Company

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lin, T.-A.
Right arrow Articles by Lawrence, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lin, T.-A.
Right arrow Articles by Lawrence, J. C., , Jr.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Volume 270, Number 31, Issue of August 04, pp. 18531-18538, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Control of PHAS-I by Insulin in 3T3-L1 Adipocytes
SYNTHESIS, DEGRADATION, AND PHOSPHORYLATION BY A RAPAMYCIN-SENSITIVE AND MITOGEN- ACTIVATED PROTEIN KINASE-INDEPENDENT PATHWAY

(Received for publication, May 5, 1995; and in revised form, June 6, 1995)

Tai-An Lin ,  Xianming Kong ,  Alan R. Saltiel ,  Perry J. Blackshear ,  John C. Lawrence , Jr.

PHAS-I levels increased 8-fold as 3T3-L1 fibroblasts differentiated into adipocytes and acquired sensitivity to insulin. Insulin increased PHAS-I protein (3.3-fold after 2 days), the rate of PHAS-I synthesis (3-fold after 1 h), and the half-life of the protein (from 1.5 to 2.5 days). Insulin also increased the phosphorylation of PHAS-I and promoted dissociation of the PHAS-Ibulleteukaryotic initiation factor-4E (eIF-4E) complex, effects that were maximal within 10 min. With recombinant [H^6]PHAS-I as substrate, mitogen-activated protein (MAP) kinase was the only insulin-stimulated PHAS-I kinase detected after fractionation of extracts by Mono Q chromatography; however, MAP kinase did not readily phosphorylate [H^6]PHAS-I when the [H^6]PHAS-IbulleteIF-4E complex was the substrate. Thus, while MAP kinase may phosphorylate free PHAS-I, it is not sufficient to dissociate the complex. Moreover, rapamycin attenuated the stimulation of PHAS-I phosphorylation by insulin and markedly inhibited dissociation of PHAS-IbulleteIF-4E, without decreasing MAP kinase activity. Rapamycin abolished the effects of insulin on increasing phosphorylation of ribosomal protein S6 and on activating p70. The MAP kinase kinase inhibitor, PD 098059, markedly decreased MAP kinase activation by insulin, but it did not change PHAS-I phosphorylation or the association of PHAS-I with eIF-4E. In summary, insulin increases the expression of PHAS-I and promotes phosphorylation of multiple sites in the protein via multiple transduction pathways, one of which is rapamycin-sensitive and independent of MAP kinase. Rapamycin may inhibit translation initiation by increasing PHAS-I binding to eIF-4E.



Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 RNAHome page
L. Rong, M. Livingstone, R. Sukarieh, E. Petroulakis, A.-C. Gingras, K. Crosby, B. Smith, R. D. Polakiewicz, J. Pelletier, M. A. Ferraiuolo, et al.
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs
RNA, July 1, 2008; 14(7): 1318 - 1327.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Wang, T. E. Harris, and J. C. Lawrence Jr.
Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation
J. Biol. Chem., June 6, 2008; 283(23): 15619 - 15627.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
T. C. Vary and C. J. Lynch
Nutrient Signaling Components Controlling Protein Synthesis in Striated Muscle
J. Nutr., August 1, 2007; 137(8): 1835 - 1843.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Wang, T. E. Harris, R. A. Roth, and J. C. Lawrence Jr
PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding
J. Biol. Chem., July 6, 2007; 282(27): 20036 - 20044.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. C. Vary, S. R. Kimball, and A. Sumner
Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R778 - R787.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Wang, C. J. Rhodes, and J. C. Lawrence Jr.
Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1
J. Biol. Chem., August 25, 2006; 281(34): 24293 - 24303.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
W.-H. Shen, D. W Boyle, P. Wisniowski, A. Bade, and E. A Liechty
Insulin and IGF-I stimulate the formation of the eukaryotic initiation factor 4F complex and protein synthesis in C2C12 myotubes independent of availability of external amino acids
J. Endocrinol., May 1, 2005; 185(2): 275 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
K. Inoki, H. Ouyang, Y. Li, and K.-L. Guan
Signaling by Target of Rapamycin Proteins in Cell Growth Control
Microbiol. Mol. Biol. Rev., March 1, 2005; 69(1): 79 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. C. Vary, G. Deiter, and S. A. Goodman
Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling
Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H121 - H128.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. E. Kim and J. Chen
Regulation of Peroxisome Proliferator-Activated Receptor-{gamma} Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis
Diabetes, November 1, 2004; 53(11): 2748 - 2756.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Murakami, T. Sasaoka, T. Wada, K. Fukui, K. Nagira, H. Ishihara, I. Usui, and M. Kobayashi
Impact of Src Homology 2-Containing Inositol 5'-Phosphatase 2 on the Regulation of Insulin Signaling Leading to Protein Synthesis in 3T3-L1 Adipocytes Cultured with Excess Amino Acids
Endocrinology, July 1, 2004; 145(7): 3215 - 3223.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
N. Oshiro, K.-i. Yoshino, S. Hidayat, C. Tokunaga, K. Hara, S. Eguchi, J. Avruch, and K. Yonezawa
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
Genes Cells, April 1, 2004; 9(4): 359 - 366.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
T. E. Harris and J. C. Lawrence Jr.
TOR Signaling
Sci. Signal., December 9, 2003; 2003(212): re15 - re15.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. M. Peralba, L. deGraffenried, W. Friedrichs, L. Fulcher, V. Grunwald, G. Weiss, and M. Hidalgo
Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients
Clin. Cancer Res., August 1, 2003; 9(8): 2887 - 2892.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
K. Yonezawa
Identification of TOR-interacting Proteins
Mol. Interv., June 1, 2003; 3(4): 189 - 193.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. M. Choi, L. P. McMahon, and J. C. Lawrence Jr.
Two Motifs in the Translational Repressor PHAS-I Required for Efficient Phosphorylation by Mammalian Target of Rapamycin and for Recognition by Raptor
J. Biol. Chem., May 23, 2003; 278(22): 19667 - 19673.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Nojima, C. Tokunaga, S. Eguchi, N. Oshiro, S. Hidayat, K.-i. Yoshino, K. Hara, N. Tanaka, J. Avruch, and K. Yonezawa
The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif
J. Biol. Chem., April 25, 2003; 278(18): 15461 - 15464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. Roh, J. Han, A. Tzatsos, and K. V. Kandror
Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E322 - E330.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Senthil, G. G. Choudhury, H. E. Abboud, N. Sonenberg, and B. S. Kasinath
Regulation of protein synthesis by IGF-I in proximal tubular epithelial cells
Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1226 - F1236.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. P. McMahon, K. M. Choi, T.-A. Lin, R. T. Abraham, and J. C. Lawrence Jr.
The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin
Mol. Cell. Biol., November 1, 2002; 22(21): 7428 - 7438.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Anand, J. M. Boylan, Y. Ou, and P. A. Gruppuso
Insulin signaling during perinatal liver development in the rat
Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E844 - E852.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. Shen, D. Mallon, D. W. Boyle, and E. A. Liechty
IGF-I and insulin regulate eIF4F formation by different mechanisms in muscle and liver in the ovine fetus
Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E593 - E603.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. P. Herbert, A. R. Tee, and C. G. Proud
The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites
J. Biol. Chem., March 22, 2002; 277(13): 11591 - 11596.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Liu, Y. Zhang, A. M. Bode, W.-Y. Ma, and Z. Dong
Phosphorylation of 4E-BP1 Is Mediated by the p38/MSK1 Pathway in Response to UVB Irradiation
J. Biol. Chem., March 8, 2002; 277(11): 8810 - 8816.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A.-C. Gingras, B. Raught, S. P. Gygi, A. Niedzwiecka, M. Miron, S. K. Burley, R. D. Polakiewicz, A. Wyslouch-Cieszynska, R. Aebersold, and N. Sonenberg
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
Genes & Dev., November 1, 2001; 15(21): 2852 - 2864.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. C. Vary, C. J. Lynch, and C. H. Lang
Effects of chronic alcohol consumption on regulation of myocardial protein synthesis
Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1242 - H1251.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A.-C. Gingras, B. Raught, and N. Sonenberg
Regulation of translation initiation by FRAP/mTOR
Genes & Dev., April 1, 2001; 15(7): 807 - 826.
[Full Text]

Home page
 DiabetesHome page
G. Xu, G. Kwon, W. S. Cruz, C. A. Marshall, and M. L. McDaniel
Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic {beta}-Cells
Diabetes, February 1, 2001; 50(2): 353 - 360.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
M. Montcouquiol and J. T. Corwin
Intracellular Signals That Control Cell Proliferation in Mammalian Balance Epithelia: Key Roles for Phosphatidylinositol-3 Kinase, Mammalian Target of Rapamycin, and S6 Kinases in Preference to Calcium, Protein Kinase C, and Mitogen-Activated Protein Kinase
J. Neurosci., January 15, 2001; 21(2): 570 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. Sosnowski, P. L. Mellon, and M. A. Lawson
Activation of Translation in Pituitary Gonadotrope Cells by Gonadotropin-Releasing Hormone
Mol. Endocrinol., November 1, 2000; 14(11): 1811 - 1819.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
O. J. Shah, J. C. Anthony, S. R. Kimball, and L. S. Jefferson
4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle
Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E715 - E729.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Sekulic, C. C. Hudson, J. L. Homme, P. Yin, D. M. Otterness, L. M. Karnitz, and R. T. Abraham
A Direct Linkage between the Phosphoinositide 3-Kinase-AKT Signaling Pathway and the Mammalian Target of Rapamycin in Mitogen-stimulated and Transformed Cells
Cancer Res., July 1, 2000; 60(13): 3504 - 3513.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. D. Fluckey, S. C. Pohnert, S. G. Boyd, R. N. Cortright, T. A. Trappe, and G. L. Dohm
Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a rapamycin-sensitive pathway
Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E182 - E187.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. N. Rao
Oxidant Stress Stimulates Phosphorylation of eIF4E without an Effect on Global Protein Synthesis in Smooth Muscle Cells. LACK OF EVIDENCE FOR A ROLE OF H2O2 IN ANGIOTENSIN II-INDUCED HYPERTROPHY
J. Biol. Chem., May 26, 2000; 275(22): 16993 - 16999.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
I. Mothe-Satney, D. Yang, P. Fadden, T. A. J. Haystead, and J. C. Lawrence Jr.
Multiple Mechanisms Control Phosphorylation of PHAS-I in Five (S/T)P Sites That Govern Translational Repression
Mol. Cell. Biol., May 15, 2000; 20(10): 3558 - 3567.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
T. Ohlmann, M. Lopez-Lastra, and J.-L. Darlix
An Internal Ribosome Entry Segment Promotes Translation of the Simian Immunodeficiency Virus Genomic RNA
J. Biol. Chem., April 14, 2000; 275(16): 11899 - 11906.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. I. Rybkin, M. E. Cross, E. M. McReynolds, R. Z. Lin, and L. M. Ballou
alpha 1A Adrenergic Receptor Induces Eukaryotic Initiation Factor 4E-binding Protein 1 Phosphorylation via a Ca2+-dependent Pathway Independent of Phosphatidylinositol 3-kinase/Akt
J. Biol. Chem., February 25, 2000; 275(8): 5460 - 5465.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Deffaud and J.-L. Darlix
Characterization of an Internal Ribosomal Entry Segment in the 5' Leader of Murine Leukemia Virus env RNA
J. Virol., January 1, 2000; 74(2): 846 - 850.
[Abstract] [Full Text]

Home page
 HypertensionHome page
T. Yamakawa, S.-i. Tanaka, K. Numaguchi, Y. Yamakawa, E. D. Motley, S. Ichihara, and T. Inagami
Involvement of Rho-Kinase in Angiotensin II-Induced Hypertrophy of Rat Vascular Smooth Muscle Cells
Hypertension, January 1, 2000; 35(1): 313 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. E. Cardenas, N. S. Cutler, M. C. Lorenz, C. J. Di Como, and J. Heitman
The TOR signaling cascade regulates gene expression in response to nutrients
Genes & Dev., December 15, 1999; 13(24): 3271 - 3279.
[Abstract] [Full Text]

Home page
 Clin. Microbiol. Rev.Home page
M. E. Cardenas, M. C. Cruz, M. Del Poeta, N. Chung, J. R. Perfect, and J. Heitman
Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action
Clin. Microbiol. Rev., October 1, 1999; 12(4): 583 - 611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. J. Tuxworth Jr., H. Wada, Y. Ishibashi, and P. J. McDermott
Role of load in regulating eIF-4F complex formation in adult feline cardiocytes
Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1273 - H1282.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. O. Marx and A. R. Marks
Cell Cycle Progression and Proliferation Despite 4BP-1 Dephosphorylation
Mol. Cell. Biol., September 1, 1999; 19(9): 6041 - 6047.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. A. Parrott and D. J. Templeton
Osmotic Stress Inhibits p70/85 S6 Kinase through Activation of a Protein Phosphatase
J. Biol. Chem., August 27, 1999; 274(35): 24731 - 24736.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Cardinali, L. Fiore, N. Campioni, A. De Dominicis, and P. Pierandrei-Amaldi
Resistance of Ribosomal Protein mRNA Translation to Protein Synthesis Shutoff Induced by Poliovirus
J. Virol., August 1, 1999; 73(8): 7070 - 7076.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
M. Grewe, F. Gansauge, R. M. Schmid, G. Adler, and T. Seufferlein
Regulation of Cell Growth and Cyclin D1 Expression by the Constitutively Active FRAP-p70s6K Pathway in Human Pancreatic Cancer Cells
Cancer Res., August 1, 1999; 59(15): 3581 - 3587.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. M. Alarcon, J. Heitman, and M. E. Cardenas
Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast
Mol. Biol. Cell, August 1, 1999; 10(8): 2531 - 2546.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
K. Khaleghpour, S. Pyronnet, A.-C. Gingras, and N. Sonenberg
Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein 1 and p70 S6 Kinase Activities
Mol. Cell. Biol., June 1, 1999; 19(6): 4302 - 4310.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A.-C. Gingras, S. P. Gygi, B. Raught, R. D. Polakiewicz, R. T. Abraham, M. F. Hoekstra, R. Aebersold, and N. Sonenberg
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
Genes & Dev., June 1, 1999; 13(11): 1422 - 1437.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. J. Sherwood, S. D. Dufresne, J. F. Markuns, B. Cheatham, D. E. Moller, D. Aronson, and L. J. Goodyear
Differential regulation of MAP kinase, p70S6K, and Akt by contraction and insulin in rat skeletal muscle
Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E870 - E878.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Vilella-Bach, P. Nuzzi, Y. Fang, and J. Chen
The FKBP12-Rapamycin-binding Domain Is Required for FKBP12-Rapamycin-associated Protein Kinase Activity and G1 Progression
J. Biol. Chem., February 12, 1999; 274(7): 4266 - 4272.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Shigemitsu, Y. Tsujishita, K. Hara, M. Nanahoshi, J. Avruch, and K. Yonezawa
Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways. POSSIBLE INVOLVEMENT OF AUTOPHAGY IN CULTURED HEPATOMA CELLS
J. Biol. Chem., January 8, 1999; 274(2): 1058 - 1065.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Iiboshi, P. J. Papst, H. Kawasome, H. Hosoi, R. T. Abraham, P. J. Houghton, and N. Terada
Amino Acid-dependent Control of p70s6k. INVOLVEMENT OF tRNA AMINOACYLATION IN THE REGULATION
J. Biol. Chem., January 8, 1999; 274(2): 1092 - 1099.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. S. Fraser, V. M. Pain, and S. J. Morley
The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells
J. Biol. Chem., January 1, 1999; 274(1): 196 - 204.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. H. Scott and J. C. Lawrence Jr.
Attenuation of Mammalian Target of Rapamycin Activity by Increased cAMP in 3T3-L1 Adipocytes
J. Biol. Chem., December 18, 1998; 273(51): 34496 - 34501.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
J. E. G. McCarthy
Posttranscriptional Control of Gene Expression in Yeast
Microbiol. Mol. Biol. Rev., December 1, 1998; 62(4): 1492 - 1553.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. R. Kimball, R. L. Horetsky, and L. S. Jefferson
Implication of eIF2B Rather Than eIF4E in the Regulation of Global Protein Synthe