We report the cloning and characterization of a novel basophil CC chemokine receptor, K5-5, from the human immature basophilic cell line KU-812. The predicted protein sequence of K5-5 shows only 49% identity to the macrophage inflammatory protein-1/RANTES receptor (CC CKR-1) and 47% identity to monocyte chemotactic protein-1 receptor (b form), suggesting that this cDNA encodes a novel member of the CC chemokine receptor family. Analysis of K5-5 mRNA expression indicates that it is restricted to leukocyte-rich tissues. In addition, we have shown significant levels of K5-5 mRNA in human basophils, which were up-regulated by treatment with interleukin-5. The CC chemokines, macrophage inflammatory protein-1, RANTES, and monocyte chemotactic protein-1 were able to stimulate a Ca-activated chloride channel in Xenopus laevis oocytes injected with K5-5 cRNA, whereas no signal was detected in response to monocyte chemotactic protein-2, macrophage inflammatory protein-1, or the CXC chemokine, interleukin-8. Taken together, these results indicate for the first time the presence of a CC chemokine receptor on basophils, which functions as a ``shared'' CC chemokine receptor and may therefore be implicated in the pathogenesis of basophil-mediated allergic diseases.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				A. W. Mailloux and M. R. I. Young NK-Dependent Increases in CCL22 Secretion Selectively Recruits Regulatory T Cells to the Tumor Microenvironment J. Immunol., March 1, 2009; 182(5): 2753 - 2765. [Abstract] [Full Text] [PDF]

				R. S. Y. Wong, V. Bodart, M. Metz, J. Labrecque, G. Bridger, and S. P. Fricker Comparison of the Potential Multiple Binding Modes of Bicyclam, Monocylam, and Noncyclam Small-Molecule CXC Chemokine Receptor 4 Inhibitors Mol. Pharmacol., December 1, 2008; 74(6): 1485 - 1495. [Abstract] [Full Text] [PDF]

				T. Traeger, W. Kessler, V. Assfalg, K. Cziupka, P. Koerner, C. Dassow, K. Breitbach, M. Mikulcak, I. Steinmetz, K. Pfeffer, et al. Detrimental Role of CC Chemokine Receptor 4 in Murine Polymicrobial Sepsis Infect. Immun., November 1, 2008; 76(11): 5285 - 5293. [Abstract] [Full Text] [PDF]

				I. A. Khasabova, C. L. Stucky, C. Harding-Rose, L. Eikmeier, A. J. Beitz, L. G. Coicou, A. E. Hanson, D. A. Simone, and V. S. Seybold Chemical Interactions between Fibrosarcoma Cancer Cells and Sensory Neurons Contribute to Cancer Pain J. Neurosci., September 19, 2007; 27(38): 10289 - 10298. [Abstract] [Full Text] [PDF]

				C. E. Brown, R. P. Vishwanath, B. Aguilar, R. Starr, J. Najbauer, K. S. Aboody, and M. C. Jensen Tumor-Derived Chemokine MCP-1/CCL2 Is Sufficient for Mediating Tumor Tropism of Adoptively Transferred T Cells J. Immunol., September 1, 2007; 179(5): 3332 - 3341. [Abstract] [Full Text] [PDF]

				N. F. Pinheiro Jr., M. D. R. Hermida, M. P. Macedo, J. Mengel, A. Bafica, and W. L. C. dos-Santos Leishmania Infection Impairs {beta}1-Integrin Function and Chemokine Receptor Expression in Mononuclear Phagocytes Infect. Immun., July 1, 2006; 74(7): 3912 - 3921. [Abstract] [Full Text] [PDF]

				R. Niwa, M. Sakurada, Y. Kobayashi, A. Uehara, K. Matsushima, R. Ueda, K. Nakamura, and K. Shitara Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density Clin. Cancer Res., March 15, 2005; 11(6): 2327 - 2336. [Abstract] [Full Text] [PDF]

				B. OSTERUD and E. BJORKLID Role of Monocytes in Atherogenesis Physiol Rev, October 1, 2003; 83(4): 1069 - 1112. [Abstract] [Full Text] [PDF]

				S. Senechal, P. de Nadai, N. Ralainirina, A. Scherpereel, H. Vorng, P. Lassalle, A.-B. Tonnel, A. Tsicopoulos, and B. Wallaert Effect of Diesel on Chemokines and Chemokine Receptors Involved in Helper T Cell Type 1/Type 2 Recruitment in Patients with Asthma Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 215 - 221. [Abstract] [Full Text] [PDF]

				K. Ichiyama, S. Yokoyama-Kumakura, Y. Tanaka, R. Tanaka, K. Hirose, K. Bannai, T. Edamatsu, M. Yanaka, Y. Niitani, N. Miyano-Kurosaki, et al. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity PNAS, April 1, 2003; 100(7): 4185 - 4190. [Abstract] [Full Text] [PDF]

				L. Agrawal, Z. Vanhorn-Ali, and G. Alkhatib Multiple determinants are involved in HIV coreceptor use as demonstrated by CCR4/CCL22 interaction in peripheral blood mononuclear cells (PBMCs) J. Leukoc. Biol., November 1, 2002; 72(5): 1063 - 1074. [Abstract] [Full Text] [PDF]

				C.-C. Ku, J. A. Padilla, C. Grose, E. C. Butcher, and A. M. Arvin Tropism of Varicella-Zoster Virus for Human Tonsillar CD4+ T Lymphocytes That Express Activation, Memory, and Skin Homing Markers J. Virol., October 11, 2002; 76(22): 11425 - 11433. [Abstract] [Full Text] [PDF]

				H. Katayama, A. Yokoyama, N. Kohno, K. Sakai, K. Hiwada, H. Yamada, and K. Hirai Production of Eosinophilic Chemokines by Normal Pleural Mesothelial Cells Am. J. Respir. Cell Mol. Biol., April 1, 2002; 26(4): 398 - 403. [Abstract] [Full Text] [PDF]

				A. Prat, K. Biernacki, J.-F. Lavoie, J. Poirier, P. Duquette, and J. P. Antel Migration of Multiple Sclerosis Lymphocytes Through Brain Endothelium Arch Neurol, March 1, 2002; 59(3): 391 - 397. [Abstract] [Full Text] [PDF]

				L. A. Jopling, I. Sabroe, D. P. Andrew, T. J. Mitchell, Y. Li, M. R. Hodge, T. J. Williams, and J. E. Pease The Identification, Characterization, and Distribution of Guinea Pig CCR4 and Epitope Mapping of a Blocking Antibody J. Biol. Chem., February 22, 2002; 277(9): 6864 - 6873. [Abstract] [Full Text] [PDF]

				E. A. de Wynter, C. M. Heyworth, N. Mukaida, E. Jaworska, A. Weffort-Santos, K. Matushima, and N. G. Testa CCR1 chemokine receptor expression isolates erythroid from granulocyte-macrophage progenitors J. Leukoc. Biol., September 1, 2001; 70(3): 455 - 460. [Abstract] [Full Text] [PDF]

				M. Iikura, M. Miyamasu, M. Yamaguchi, H. Kawasaki, K. Matsushima, M. Kitaura, Y. Morita, O. Yoshie, K. Yamamoto, and K. Hirai Chemokine receptors in human basophils: inducible expression of functional CXCR4 J. Leukoc. Biol., July 1, 2001; 70(1): 113 - 120. [Abstract] [Full Text] [PDF]

				C. Blanpain, R. Buser, C. A. Power, M. Edgerton, C. Buchanan, M. Mack, G. Simmons, P. R. Clapham, M. Parmentier, and A. E. I. Proudfoot A chimeric MIP-1{alpha}/RANTES protein demonstrates the use of different regions of the RANTES protein to bind and activate its receptors J. Leukoc. Biol., June 1, 2001; 69(6): 977 - 985. [Abstract] [Full Text] [PDF]

				Y. Kim, S.-s. J. Sung, W. A. Kuziel, S. Feldman, S. M. Fu, and C. E. Rose Jr Enhanced Airway Th2 Response After Allergen Challenge in Mice Deficient in CC Chemokine Receptor-2 (CCR2) J. Immunol., April 15, 2001; 166(8): 5183 - 5192. [Abstract] [Full Text] [PDF]

				A. Heinemann, A. Hartnell, V. E. L. Stubbs, K. Murakami, D. Soler, G. LaRosa, P. W. Askenase, T. J. Williams, and I. Sabroe Basophil Responses to Chemokines Are Regulated by Both Sequential and Cooperative Receptor Signaling J. Immunol., December 15, 2000; 165(12): 7224 - 7233. [Abstract] [Full Text] [PDF]

				K. J. Clemetson, J. M. Clemetson, A. E. I. Proudfoot, C. A. Power, M. Baggiolini, and T. N. C. Wells Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets Blood, December 15, 2000; 96(13): 4046 - 4054. [Abstract] [Full Text] [PDF]

				T. Nanki and P. E. Lipsky Lack of correlation between chemokine receptor and Th1/Th2 cytokine expression by individual memory T cells Int. Immunol., December 1, 2000; 12(12): 1659 - 1667. [Abstract] [Full Text] [PDF]

				T. Nanki, K. Hayashida, H. S. El-Gabalawy, S. Suson, K. Shi, H. J. Girschick, S. Yavuz, and P. E. Lipsky Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium J. Immunol., December 1, 2000; 165(11): 6590 - 6598. [Abstract] [Full Text] [PDF]

				J. A. Belperio, M. D. Burdick, M. P. Keane, Y. Y. Xue, J. P. Lynch III, B. L. Daugherty, S. L. Kunkel, and R. M. Strieter The Role of the CC Chemokine, RANTES, in Acute Lung Allograft Rejection J. Immunol., July 1, 2000; 165(1): 461 - 472. [Abstract] [Full Text] [PDF]

				Y. Chvatchko, A. J. Hoogewerf, A. Meyer, S. Alouani, P. Juillard, R. Buser, F. Conquet, A. E.I. Proudfoot, T. N.C. Wells, and C. A. Power A Key Role for CC Chemokine Receptor 4 in Lipopolysaccharide-induced Endotoxic Shock J. Exp. Med., May 15, 2000; 191(10): 1755 - 1764. [Abstract] [Full Text] [PDF]

				C. Murdoch and A. Finn Chemokine receptors and their role in inflammation and infectious diseases Blood, May 15, 2000; 95(10): 3032 - 3043. [Abstract] [Full Text] [PDF]

				K. Arima, K. Nasu, H. Narahara, K. Fujisawa, N. Matsui, and I. Miyakawa Effects of lipopolysaccharide and cytokines on production of RANTES by cultured human endometrial stromal cells Mol. Hum. Reprod., March 1, 2000; 6(3): 246 - 251. [Abstract] [Full Text] [PDF]

				P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors Pharmacol. Rev., March 1, 2000; 52(1): 145 - 176. [Abstract] [Full Text] [PDF]

				N. Nasreen, K. A. Mohammed, G. Galffy, M. J. Ward, and V. B. Antony MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells Am J Physiol Lung Cell Mol Physiol, March 1, 2000; 278(3): L591 - L598. [Abstract] [Full Text] [PDF]

				G. Franchin, G. Zybarth, W. W. Dai, L. Dubrovsky, N. Reiling, H. Schmidtmayerova, M. Bukrinsky, and B. Sherry Lipopolysaccharide Inhibits HIV-1 Infection of Monocyte- Derived Macrophages Through Direct and Sustained Down-Regulation of CC Chemokine Receptor 5 J. Immunol., March 1, 2000; 164(5): 2592 - 2601. [Abstract] [Full Text] [PDF]

				C.-R. Yu, K. W. C. Peden, M. B. Zaitseva, H. Golding, and J. M. Farber CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ck{beta}-15 That Differ in Their Sensitivities to Ligand J. Immunol., February 1, 2000; 164(3): 1293 - 1305. [Abstract] [Full Text] [PDF]

				A. M. Norment, L. Y. Bogatzki, B. N. Gantner, and M. J. Bevan Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling J. Immunol., January 15, 2000; 164(2): 639 - 648. [Abstract] [Full Text] [PDF]

				J. M. Burns, G. K. Lewis, and A. L. DeVico Soluble complexes of regulated upon activation, normal T cells expressed and secreted (RANTES) and glycosaminoglycans suppress HIV-1 infection but do not induce Ca2+ signaling PNAS, December 7, 1999; 96(25): 14499 - 14504. [Abstract] [Full Text] [PDF]

				S. Ying, Q. Meng, K. Zeibecoglou, D. S. Robinson, A. Macfarlane, M. Humbert, and A. B. Kay Eosinophil Chemotactic Chemokines (Eotaxin, Eotaxin-2, RANTES, Monocyte Chemoattractant Protein-3 (MCP-3), and MCP-4), and C-C Chemokine Receptor 3 Expression in Bronchial Biopsies from Atopic and Nonatopic (Intrinsic) Asthmatics J. Immunol., December 1, 1999; 163(11): 6321 - 6329. [Abstract] [Full Text] [PDF]

				A. J. Morris and C. C. Malbon Physiological Regulation of G Protein-Linked Signaling Physiol Rev, October 1, 1999; 79(4): 1373 - 1430. [Abstract] [Full Text] [PDF]

				K F Chung and P J Barnes Cytokines in asthma Thorax, September 1, 1999; 54(9): 825 - 857. [Full Text]

				F. Hadida, V. Vieillard, L. Mollet, I. Clark-Lewis, M. Baggiolini, and P. Debre Cutting Edge: RANTES Regulates Fas Ligand Expression and Killing by HIV-Specific CD8 Cytotoxic T Cells J. Immunol., August 1, 1999; 163(3): 1105 - 1109. [Abstract] [Full Text] [PDF]

				M. Foti, F. Granucci, D. Aggujaro, E. Liboi, W. Luini, S. Minardi, A. Mantovani, S. Sozzani, and P. Ricciardi-Castagnoli Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site Int. Immunol., June 1, 1999; 11(6): 979 - 986. [Abstract] [Full Text] [PDF]

				M. A. Giembycz and M. A. Lindsay Pharmacology of the Eosinophil Pharmacol. Rev., June 1, 1999; 51(2): 213 - 340. [Abstract] [Full Text] [PDF]

				J. Dürig, N. G. Testa, and C. M. Heyworth Distinct Biological Effects of Macrophage Inflammatory Protein-1{alpha} and Stroma-Derived Factor-1{alpha} on CD34+ Hemopoietic Cells Stem Cells, March 1, 1999; 17(2): 62 - 71. [Abstract] [Full Text]

				L. Pedroza-Martins, K. B. Gurney, B. E. Torbett, and C. H. Uittenbogaart Differential Tropism and Replication Kinetics of Human Immunodeficiency Virus Type 1 Isolates in Thymocytes: Coreceptor Expression Allows Viral Entry, but Productive Infection of Distinct Subsets Is Determined at the Postentry Level J. Virol., December 1, 1998; 72(12): 9441 - 9452. [Abstract] [Full Text] [PDF]

				P. J. Barnes, K. F. Chung, and C. P. Page Inflammatory Mediators of Asthma: An Update Pharmacol. Rev., December 1, 1998; 50(4): 515 - 596. [Abstract] [Full Text] [PDF]

				D. D'Ambrosio, A. Iellem, R. Bonecchi, D. Mazzeo, S. Sozzani, A. Mantovani, and F. Sinigaglia Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells J. Immunol., November 15, 1998; 161(10): 5111 - 5115. [Abstract] [Full Text] [PDF]

				J. Durig, E. A. de Wynter, C. Kasper, M. A. Cross, J. Chang, N. G. Testa, and C. M. Heyworth Expression of Macrophage Inflammatory Protein-1alpha Receptors in Human CD34+ Hematopoietic Cells and Their Modulation by Tumor Necrosis Factor-alpha and Interferon-gamma Blood, November 1, 1998; 92(9): 3073 - 3081. [Abstract] [Full Text] [PDF]

				A. Albini, S. Ferrini, R. Benelli, S. Sforzini, D. Giunciuglio, M. G. Aluigi, A. E. I. Proudfoot, S. Alouani, T. N. C. Wells, G. Mariani, et al. HIV-1 Tat protein mimicry of chemokines PNAS, October 27, 1998; 95(22): 13153 - 13158. [Abstract] [Full Text] [PDF]

				S. Struyf, P. Proost, S. Sozzani, A. Mantovani, A. Wuyts, E. De Clercq, D. Schols, and J. Van Damme Cutting Edge: Enhanced Anti-HIV-1 Activity and Altered Chemotactic Potency of NH2-Terminally Processed Macrophage-Derived Chemokine (MDC) Imply an Additional MDC Receptor J. Immunol., September 15, 1998; 161(6): 2672 - 2675. [Abstract] [Full Text] [PDF]

				E.A. de Wynter, J. Durig, M.A. Cross, C.M. Heyworth, and N.G. Testa Differential Response of CD34+ Cells Isolated from Cord Blood and Bone Marrow to MIP-1{alpha} and the Expression of MIP-1{alpha} Receptors on These Immature Cells Stem Cells, September 1, 1998; 16(5): 349 - 356. [Abstract] [Full Text]

				F. Hadida, V. Vieillard, B. Autran, I. Clark-Lewis, M. Baggiolini, and P. Debre HIV-specific T Cell Cytotoxicity Mediated by RANTES Via the Chemokine Receptor CCR3 J. Exp. Med., August 3, 1998; 188(3): 609 - 614. [Abstract] [Full Text] [PDF]

				O. Pleskoff, C. Treboute, and M. Alizon The Cytomegalovirus-Encoded Chemokine Receptor US28 Can Enhance Cell-Cell Fusion Mediated by Different Viral Proteins J. Virol., August 1, 1998; 72(8): 6389 - 6397. [Abstract] [Full Text] [PDF]

				M. Mellado, J. M. Rodriguez-Frade, A. Aragay, G. del Real, A. M. Martin, A. J. Vila-Coro, A. Serrano, F. Mayor Jr., and C. Martinez-A. The Chemokine Monocyte Chemotactic Protein 1 Triggers Janus Kinase 2 Activation and Tyrosine Phosphorylation of the CCR2B Receptor J. Immunol., July 15, 1998; 161(2): 805 - 813. [Abstract] [Full Text] [PDF]

				F. Sallusto, D. Lenig, C. R. Mackay, and A. Lanzavecchia Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes J. Exp. Med., March 16, 1998; 187(6): 875 - 883. [Abstract] [Full Text] [PDF]

				I. M. Hayes, N. J. Jordan, S. Towers, G. Smith, J. R. Paterson, J. J. Earnshaw, A. G. Roach, J. Westwick, and R. J. Williams Human Vascular Smooth Muscle Cells Express Receptors for CC Chemokines Arterioscler. Thromb. Vasc. Biol., March 1, 1998; 18(3): 397 - 403. [Abstract] [Full Text] [PDF]

				B. Lu, B. J. Rutledge, L. Gu, J. Fiorillo, N. W. Lukacs, S. L. Kunkel, R. North, C. Gerard, and B. J. Rollins Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1-deficient Mice J. Exp. Med., February 16, 1998; 187(4): 601 - 608. [Abstract] [Full Text] [PDF]

				S. K. Gupta, P. G. Lysko, K. Pillarisetti, E. Ohlstein, and J. M. Stadel Chemokine Receptors in Human Endothelial Cells. FUNCTIONAL EXPRESSION OF CXCR4 AND ITS TRANSCRIPTIONAL REGULATION BY INFLAMMATORY CYTOKINES J. Biol. Chem., February 13, 1998; 273(7): 4282 - 4287. [Abstract] [Full Text] [PDF]

				H. L. Tiffany, G. Alkhatib, C. Combadiere, E. A. Berger, and P. M. Murphy CC Chemokine Receptors 1 and 3 Are Differentially Regulated by IL-5 During Maturation of Eosinophilic HL-60 Cells J. Immunol., February 1, 1998; 160(3): 1385 - 1392. [Abstract] [Full Text] [PDF]

				T. Imai, D. Chantry, C. J. Raport, C. L. Wood, M. Nishimura, R. Godiska, O. Yoshie, and P. W. Gray Macrophage-derived Chemokine Is a Functional Ligand for the CC Chemokine Receptor 4 J. Biol. Chem., January 16, 1998; 273(3): 1764 - 1768. [Abstract] [Full Text] [PDF]

				R. J. B. Nibbs, S. M. Wylie, J. Yang, N. R. Landau, and G. J. Graham Cloning and Characterization of a Novel Promiscuous Human beta -Chemokine Receptor D6 J. Biol. Chem., December 19, 1997; 272(51): 32078 - 32083. [Abstract] [Full Text] [PDF]

				H. M. Sarau, J. A. Rush, J. J. Foley, M. E. Brawner, D. B. Schmidt, J. R. White, and M. S. Barnette Characterization of Functional Chemokine Receptors (CCR1 and CCR2) on EoL-3 Cells: A Model System to Examine the Role of Chemokines in Cell Function J. Pharmacol. Exp. Ther., October 1, 1997; 283(1): 411 - 418. [Abstract] [Full Text]

				C. A. Power, D. J. Church, A. Meyer, S. Alouani, A. E.I. Proudfoot, I. Clark-Lewis, S. Sozzani, A. Mantovani, and T. N.C. Wells Cloning and Characterization of a Specific Receptor for the Novel CC Chemokine MIP-3alpha from Lung Dendritic Cells J. Exp. Med., September 15, 1997; 186(6): 825 - 835. [Abstract] [Full Text] [PDF]

				B. J. Rollins Chemokines Blood, August 1, 1997; 90(3): 909 - 928. [Full Text] [PDF]

				H. L. Tiffany, L. L. Lautens, J.-L. Gao, J. Pease, M. Locati, C. Combadiere, W. Modi, T. I. Bonner, and P. M. Murphy Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309 J. Exp. Med., July 7, 1997; 186(1): 165 - 170. [Abstract] [Full Text] [PDF]

				T. A. Berkhout, H. M. Sarau, K. Moores, J. R White, N. Elshourbagy, E. Appelbaum, J. Makwana, J. J. Foley, D. B Schmidt, C. Imburgia, et al. Cloning, in Vitro Expression, and Functional Characterization of a Novel Human CC Chemokine of the Monocyte Chemotactic Protein (MCP) Family (MCP-4) That Binds and Signals through the CC Chemokine Receptor 2B J. Biol. Chem., June 27, 1997; 272(26): 16404 - 16413. [Abstract] [Full Text] [PDF]

				B.-S. Youn, S.-H. Kim, M. S. Lyu, C. A. Kozak, D. D. Taub, and B. S. Kwon Molecular Cloning and Characterization of a cDNA, CHEMR1, Encoding a Chemokine Receptor With a Homology to the Human C-C Chemokine Receptor, CCR-4 Blood, June 15, 1997; 89(12): 4448 - 4460. [Abstract] [Full Text] [PDF]

				M. Baba, T. Imai, M. Nishimura, M. Kakizaki, S. Takagi, K. Hieshima, H. Nomiyama, and O. Yoshie Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC J. Biol. Chem., June 6, 1997; 272(23): 14893 - 14898. [Abstract] [Full Text] [PDF]

				T. Imai, M. Baba, M. Nishimura, M. Kakizaki, S. Takagi, and O. Yoshie The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4 J. Biol. Chem., June 6, 1997; 272(23): 15036 - 15042. [Abstract] [Full Text] [PDF]

				J.-L. Gao, T. A. Wynn, Y. Chang, E. J. Lee, H. E. Broxmeyer, S. Cooper, H. L. Tiffany, H. Westphal, J. Kwon-Chung, and P. M. Murphy Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1-Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1 J. Exp. Med., June 2, 1997; 185(11): 1959 - 1968. [Abstract] [Full Text] [PDF]

				R. Yoshida, T. Imai, K. Hieshima, J. Kusuda, M. Baba, M. Kitaura, M. Nishimura, M. Kakizaki, H. Nomiyama, and O. Yoshie Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7 J. Biol. Chem., May 23, 1997; 272(21): 13803 - 13809. [Abstract] [Full Text] [PDF]

				R. Godiska, D. Chantry, C. J. Raport, S. Sozzani, P. Allavena, D. Leviten, A. Mantovani, and P. W. Gray Human Macrophage-derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer Cells J. Exp. Med., May 5, 1997; 185(9): 1595 - 1604. [Abstract] [Full Text] [PDF]

				L.-M. Wong, S. J. Myers, C.-L. Tsou, J. Gosling, H. Arai, and I. F. Charo Organization and Differential Expression of the Human Monocyte Chemoattractant Protein 1Receptor Gene. EVIDENCE FOR THE ROLE OF THE CARBOXYL-TERMINAL TAIL IN RECEPTOR TRAFFICKING J. Biol. Chem., January 10, 1997; 272(2): 1038 - 1045. [Abstract] [Full Text] [PDF]

				C.-A. N. Dunstan, M. N. Salafranca, S. Adhikari, Y. Xia, L. Feng, and J. K. Harrison Identification of Two Rat Genes Orthologous to the Human Interleukin-8 Receptors J. Biol. Chem., December 20, 1996; 271(51): 32770 - 32776. [Abstract] [Full Text] [PDF]

				T. Imai, T. Yoshida, M. Baba, M. Nishimura, M. Kakizaki, and O. Yoshie Molecular Cloning of a Novel T Cell-directed CC Chemokine Expressed in Thymus by Signal Sequence Trap Using Epstein-Barr Virus Vector J. Biol. Chem., August 30, 1996; 271(35): 21514 - 21521. [Abstract] [Full Text] [PDF]

				S. K. Ahuja and P. M. Murphy The CXC Chemokines Growth-regulated Oncogene (GRO) alpha , GRObeta , GROgamma , Neutrophil-activating Peptide-2, and Epithelial Cell-derived Neutrophil-activating Peptide-78 Are Potent Agonists for the Type B, but Not the Type A, Human Interleukin-8 Receptor J. Biol. Chem., August 23, 1996; 271(34): 20545 - 20550. [Abstract] [Full Text] [PDF]

				F. S. Monteclaro and I. F. Charo The Amino-terminal Extracellular Domain of the MCP-1 Receptor, but Not the RANTES/MIP-1alpha Receptor, Confers Chemokine Selectivity. EVIDENCE FOR A TWO-STEP MECHANISM FOR MCP-1 RECEPTOR ACTIVATION J. Biol. Chem., August 9, 1996; 271(32): 19084 - 19092. [Abstract] [Full Text] [PDF]

				C. J. Raport, J. Gosling, V. L. Schweickart, P. W. Gray, and I. F. Charo Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1beta , and MIP-1alpha J. Biol. Chem., July 19, 1996; 271(29): 17161 - 17166. [Abstract] [Full Text] [PDF]

				A. Meyer, A. J. Coyle, A. E.I. Proudfoot, T. N.C. Wells, and C. A. Power Cloning and Characterization of a Novel Murine Macrophage Inflammatory Protein-1alpha Receptor J. Biol. Chem., June 14, 1996; 271(24): 14445 - 14451. [Abstract] [Full Text] [PDF]

				J.-H. Gong, M. Uguccioni, B. Dewald, M. Baggiolini, and I. Clark-Lewis RANTES and MCP-3 Antagonists Bind Multiple Chemokine Receptors J. Biol. Chem., May 3, 1996; 271(18): 10521 - 10527. [Abstract] [Full Text] [PDF]

				M. Kitaura, T. Nakajima, T. Imai, S. Harada, C. Combadiere, H. L. Tiffany, P. M. Murphy, and O. Yoshie Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine, and Identification of a Specific Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3 J. Biol. Chem., March 29, 1996; 271(13): 7725 - 7730. [Abstract] [Full Text] [PDF]

				M. Lusti-Narasimhan, A. Chollet, C. A. Power, B. Allet, A. E. I. Proudfoot, and T. N. C. Wells A Molecular Switch of Chemokine Receptor Selectivity J. Biol. Chem., February 9, 1996; 271(6): 3148 - 3153. [Abstract] [Full Text] [PDF]

				C. Combadiere, S. K. Ahuja, J. Van Damme, H. L. Tiffany, J.-L. Gao, and P. M. Murphy Monocyte Chemoattractant Protein-3 Is a Functional Ligand for CC Chemokine Receptors 1 and 2B J. Biol. Chem., December 15, 1995; 270(50): 29671 - 29675. [Abstract] [Full Text] [PDF]