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(Received for publication, June 28, 1995 ) Extracts of Saccharomyces cerevisiae were shown to
support the elongation of oligodeoxynucleotides with telomere-like
sequences. The primer sequence specificity of this elongation activity,
its incorporation of dG and dT but not dA or dC from the corresponding
triphosphates, and its sensitivity to RNase A and RNase H are all
consistent with it being a telomerase. In contrast to the reported
properties of other telomerases, the presence of ATP enhances the
efficiency of initiation of the yeast enzyme and improves its
processivity. Hydrolysis of ATP appears to be unnecessary for the
observed effects, as the
Volume 270,
Number 37,
Issue of September 15, pp. 21453-21456, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
,-imido or the
-thio derivative
of ATP is nearly as effective.
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