Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lamphear, B. J.
Right arrow Articles by Rhoads, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lamphear, B. J.
Right arrow Articles by Rhoads, R. E.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Volume 270, Number 37, Issue of September 15, pp. 21975-21983, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases
IMPLICATIONS FOR CAP-DEPENDENT AND CAP-INDEPENDENT TRANSLATIONAL INITIATION

(Received for publication, April 20, 1995)

Barry J. Lamphear ,&nbsp;<WBR> Regina Kirchweger ,&nbsp;<WBR> Tim Skern ,&nbsp;<WBR> Robert E. Rhoads

Cap-dependent binding of mRNA to the 40 S ribosomal subunit during translational initiation requires the association of eukaryotic initiation factor 4G (eIF4G; formerly eIF-4 and p220) with other initiation factors, notably eIF4E, eIF4A, and eIF3. Infection of cells by picornaviruses results in proteolytic cleavage of eIF4G and generation of a cap-independent translational state. Rhinovirus 2A protease and foot-and-mouth-disease virus L protease were used to analyze the association of eIF4G with eIF4A, eIF4E, and eIF3. Both proteases bisect eIF4G into N- and C-terminal fragments termed cp(N) and cp(C). cp(N) was shown to contain the eIF4E-binding site, as judged by retention on m^7GTP-Sepharose, whereas cp(C) was bound to eIF3 and eIF4A, based on ultracentrifugal co-sedimentation. Further proteolysis of cp(N) by L protease produced an 18-kDa polypeptide termed cp which retained eIF4E binding activity and corresponded to amino acid residues 319-479 of rabbit eIF4G. Further proteolysis of cp(C) yielded several smaller fragments. cp (887-1402) contained the eIF4A binding site, whereas cp (480-886) contained the eIF3 binding site. These results suggest that cleavage by picornaviral proteases at residues 479-486 separates eIF4G into two domains, one required for recruiting capped mRNAs and one for attaching mRNA to the ribosome and directing helicase activity. Only the latter would appear to be necessary for internal initiation of picornaviral RNAs.




Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
Proc. Natl. Acad. Sci. USAHome page
S. de Breyne, Y. Yu, A. Unbehaun, T. V. Pestova, and C. U. T. Hellen
Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites
PNAS, June 9, 2009; 106(23): 9197 - 9202.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
Y. Yoffe, M. Leger, A. Zinoviev, J. Zuberek, E. Darzynkiewicz, G. Wagner, and M. Shapira
Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E-eIF4G interactions
Nucleic Acids Res., June 1, 2009; 37(10): 3243 - 3253.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
J. M. Morrison and V. R. Racaniello
Proteinase 2Apro Is Essential for Enterovirus Replication in Type I Interferon-Treated Cells
J. Virol., May 1, 2009; 83(9): 4412 - 4422.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
A. Yanagiya, Y. V. Svitkin, S. Shibata, S. Mikami, H. Imataka, and N. Sonenberg
Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap
Mol. Cell. Biol., March 15, 2009; 29(6): 1661 - 1669.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
M. Kimura, K. Ishida, S.-i. Kashiwabara, and T. Baba
Characterization of Two Cytoplasmic Poly(A)-Binding Proteins, PABPC1 and PABPC2, in Mouse Spermatogenic Cells
Biol Reprod, March 1, 2009; 80(3): 545 - 554.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Csibi, M. P. Leibovitch, K. Cornille, L. A. Tintignac, and S. A. Leibovitch
MAFbx/Atrogin-1 Controls the Activity of the Initiation Factor eIF3-f in Skeletal Muscle Atrophy by Targeting Multiple C-terminal Lysines
J. Biol. Chem., February 13, 2009; 284(7): 4413 - 4421.
[Abstract] [Full Text] [PDF]


Home page
RNAHome page
C. Kaiser, E. Y. Dobrikova, S. S. Bradrick, M. Shveygert, J. T. Herbert, and M. Gromeier
Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo
RNA, October 1, 2008; 14(10): 2170 - 2182.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
J.-E. Kim, I. Ryu, W. J. Kim, O.-K. Song, J. Ryu, M. Y. Kwon, J. H. Kim, and S. K. Jang
Proline-Rich Transcript in Brain Protein Induces Stress Granule Formation
Mol. Cell. Biol., January 15, 2008; 28(2): 803 - 813.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
D. Dhar, S. Roy, and S. Das
Translational control of the interferon regulatory factor 2 mRNA by IRES element
Nucleic Acids Res., August 13, 2007; (2007) gkm524v1.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
T. C. Vary and C. J. Lynch
Nutrient Signaling Components Controlling Protein Synthesis in Striated Muscle
J. Nutr., August 1, 2007; 137(8): 1835 - 1843.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
T. C. Vary, G. Deiter, and C. J. Lynch
Rapamycin Limits Formation of Active Eukaryotic Initiation Factor 4F Complex Following Meal Feeding in Rat Hearts
J. Nutr., August 1, 2007; 137(8): 1857 - 1862.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. ProteomicsHome page
E. Damoc, C. S. Fraser, M. Zhou, H. Videler, G. L. Mayeur, J. W. B. Hershey, J. A. Doudna, C. V. Robinson, and J. A. Leary
Structural Characterization of the Human Eukaryotic Initiation Factor 3 Protein Complex by Mass Spectrometry
Mol. Cell. Proteomics, July 1, 2007; 6(7): 1135 - 1146.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
T. C. Vary, J. C. Anthony, L. S. Jefferson, S. R. Kimball, and C. J. Lynch
Rapamycin blunts nutrient stimulation of eIF4G, but not PKC{varepsilon} phosphorylation, in skeletal muscle
Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E188 - E196.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
N. Oulhen, P. Salaun, B. Cosson, P. Cormier, and J. Morales
After fertilization of sea urchin eggs, eIF4G is post-translationally modified and associated with the cap-binding protein eIF4E
J. Cell Sci., February 1, 2007; 120(3): 425 - 434.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. M. Hinton, M. J. Coldwell, G. A. Carpenter, S. J. Morley, and V. M. Pain
Functional Analysis of Individual Binding Activities of the Scaffold Protein eIF4G
J. Biol. Chem., January 19, 2007; 282(3): 1695 - 1708.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Castello, E. Alvarez, and L. Carrasco
Differential Cleavage of eIF4GI and eIF4GII in Mammalian Cells: EFFECTS ON TRANSLATION
J. Biol. Chem., November 3, 2006; 281(44): 33206 - 33216.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
T. C. Vary and C. J. Lynch
Meal Feeding Stimulates Phosphorylation of Multiple Effector Proteins Regulating Protein Synthetic Processes in Rat Hearts
J. Nutr., September 1, 2006; 136(9): 2284 - 2290.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. Cheng and D. R. Gallie
Wheat Eukaryotic Initiation Factor 4B Organizes Assembly of RNA and eIFiso4G, eIF4A, and Poly(A)-binding Protein
J. Biol. Chem., August 25, 2006; 281(34): 24351 - 24364.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. K. LeFebvre, N. L. Korneeva, M. Trutschl, U. Cvek, R. D. Duzan, C. A. Bradley, J. W. B. Hershey, and R. E. Rhoads
Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e Subunit
J. Biol. Chem., August 11, 2006; 281(32): 22917 - 22932.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
E. Y. Dobrikova, R. N. Grisham, C. Kaiser, J. Lin, and M. Gromeier
Competitive Translation Efficiency at the Picornavirus Type 1 Internal Ribosome Entry Site Facilitated by Viral cis and trans Factors.
J. Virol., April 1, 2006; 80(7): 3310 - 3321.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
T. C. Vary and C. J. Lynch
Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation
Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E631 - E642.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Funai, J. D. Parkington, S. Carambula, and R. A. Fielding
Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1080 - R1086.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
M. Wang and K. A. Hudak
A novel interaction of pokeweed antiviral protein with translation initiation factors 4G and iso4G: a potential indirect mechanism to access viral RNAs
Nucleic Acids Res., February 21, 2006; 34(4): 1174 - 1181.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
A. V. Jivotovskaya, L. Valasek, A. G. Hinnebusch, and K. H. Nielsen
Eukaryotic Translation Initiation Factor 3 (eIF3) and eIF2 Can Promote mRNA Binding to 40S Subunits Independently of eIF4G in Yeast
Mol. Cell. Biol., February 15, 2006; 26(4): 1355 - 1372.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
N. J. Baxter, A. Roetzer, H.-D. Liebig, S. E. Sedelnikova, A. M. Hounslow, T. Skern, and J. P. Waltho
Structure and Dynamics of Coxsackievirus B4 2A Proteinase, an Enyzme Involved in the Etiology of Heart Disease
J. Virol., February 1, 2006; 80(3): 1451 - 1462.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. C. Vary
IGF-I stimulates protein synthesis in skeletal muscle through multiple signaling pathways during sepsis
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R313 - R321.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
I. M. Terenin, S. E. Dmitriev, D. E. Andreev, E. Royall, G. J. Belsham, L. O. Roberts, and I. N. Shatsky
A Cross-Kingdom Internal Ribosome Entry Site Reveals a Simplified Mode of Internal Ribosome Entry
Mol. Cell. Biol., September 1, 2005; 25(17): 7879 - 7888.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. P. Byrd, M. Zamora, and R. E. Lloyd
Translation of Eukaryotic Translation Initiation Factor 4GI (eIF4GI) Proceeds from Multiple mRNAs Containing a Novel Cap-dependent Internal Ribosome Entry Site (IRES) That Is Active during Poliovirus Infection
J. Biol. Chem., May 13, 2005; 280(19): 18610 - 18622.
[Abstract] [Full Text] [PDF]


Home page
Eukaryot CellHome page
L. Li and C. C. Wang
Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
Eukaryot. Cell, May 1, 2005; 4(5): 948 - 959.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
S. Merl, C. Michaelis, B. Jaschke, M. Vorpahl, S. Seidl, and R. Wessely
Targeting 2A Protease by RNA Interference Attenuates Coxsackieviral Cytopathogenicity and Promotes Survival in Highly Susceptible Mice
Circulation, April 5, 2005; 111(13): 1583 - 1592.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. J. Stewart, K. Smoak, M. A. Blum, and B. Sherry
Basal and Reovirus-Induced Beta Interferon (IFN-{beta}) and IFN-{beta}-Stimulated Gene Expression Are Cell Type Specific in the Cardiac Protective Response
J. Virol., March 1, 2005; 79(5): 2979 - 2987.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
D. J. Hui, F. Terenzi, W. C. Merrick, and G. C. Sen
Mouse p56 Blocks a Distinct Function of Eukaryotic Initiation Factor 3 in Translation Initiation
J. Biol. Chem., February 4, 2005; 280(5): 3433 - 3440.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. Yanagiya, Q. Jia, S. Ohka, H. Horie, and A. Nomoto
Blockade of the Poliovirus-Induced Cytopathic Effect in Neural Cells by Monoclonal Antibody against Poliovirus or the Human Poliovirus Receptor
J. Virol., February 1, 2005; 79(3): 1523 - 1532.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. L. Korneeva, E. A. First, C. A. Benoit, and R. E. Rhoads
Interaction between the NH2-terminal Domain of eIF4A and the Central Domain of eIF4G Modulates RNA-stimulated ATPase Activity
J. Biol. Chem., January 21, 2005; 280(3): 1872 - 1881.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
T. C. Vary, G. Deiter, and S. A. Goodman
Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling
Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H121 - H128.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. Lall, C. C. Friedman, M. Jankowska-Anyszka, J. Stepinski, E. Darzynkiewicz, and R. E. Davis
Contribution of Trans-splicing, 5' -Leader Length, Cap-Poly(A) Synergism, and Initiation Factors to Nematode Translation in an Ascaris suum Embryo Cell-free System
J. Biol. Chem., October 29, 2004; 279(44): 45573 - 45585.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Virol.Home page
G. Bassili, E. Tzima, Y. Song, L. Saleh, K. Ochs, and M. Niepmann
Sequence and secondary structure requirements in a highly conserved element for foot-and-mouth disease virus internal ribosome entry site activity and eIF4G binding
J. Gen. Virol., September 1, 2004; 85(9): 2555 - 2565.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. Kuyumcu-Martinez, G. Belliot, S. V. Sosnovtsev, K.-O. Chang, K. Y. Green, and R. E. Lloyd
Calicivirus 3C-Like Proteinase Inhibits Cellular Translation by Cleavage of Poly(A)-Binding Protein
J. Virol., August 1, 2004; 78(15): 8172 - 8182.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
M. J. Coldwell, L. Hashemzadeh-Bonehi, T. M. Hinton, S. J. Morley, and V. M. Pain
Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG
J. Cell Sci., May 15, 2004; 117(12): 2545 - 2555.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
R. C. Doepker, W.-L. Hsu, H. A. Saffran, and J. R. Smiley
Herpes Simplex Virus Virion Host Shutoff Protein Is Stimulated by Translation Initiation Factors eIF4B and eIF4H
J. Virol., May 1, 2004; 78(9): 4684 - 4699.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Virol.Home page
M. M. Willcocks, M. J. Carter, and L. O. Roberts
Cleavage of eukaryotic initiation factor eIF4G and inhibition of host-cell protein synthesis during feline calicivirus infection
J. Gen. Virol., May 1, 2004; 85(5): 1125 - 1130.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. de Breyne, R. S. Monney, and J. Curran
Proteolytic Processing and Translation Initiation: TWO INDEPENDENT MECHANISMS FOR THE EXPRESSION OF THE SENDAI VIRUS Y PROTEINS
J. Biol. Chem., April 16, 2004; 279(16): 16571 - 16580.
[Abstract] [Full Text] [PDF]


Home page
Clin. Microbiol. Rev.Home page
M. J. Grubman and B. Baxt
Foot-and-Mouth Disease
Clin. Microbiol. Rev., April 1, 2004; 17(2): 465 - 493.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Virol.Home page
S. Leonard, C. Viel, C. Beauchemin, N. Daigneault, M. G. Fortin, and J.-F. Laliberte
Interaction of VPg-Pro of Turnip mosaic virus with the translation initiation factor 4E and the poly(A)-binding protein in planta
J. Gen. Virol., April 1, 2004; 85(4): 1055 - 1063.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Robalino, B. Joshi, S. C. Fahrenkrug, and R. Jagus
Two Zebrafish eIF4E Family Members Are Differentially Expressed and Functionally Divergent
J. Biol. Chem., March 12, 2004; 279(11): 10532 - 10541.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. S. Fraser, J. Y. Lee, G. L. Mayeur, M. Bushell, J. A. Doudna, and J. W. B. Hershey
The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro
J. Biol. Chem., March 5, 2004; 279(10): 8946 - 8956.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
N. M. Kuyumcu-Martinez, M. E. Van Eden, P. Younan, and R. E. Lloyd
Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Protease Inhibits Host Cell Translation: a Novel Mechanism for Host Translation Shutoff
Mol. Cell. Biol., February 15, 2004; 24(4): 1779 - 1790.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
E. Alvarez, L. Menendez-Arias, and L. Carrasco
The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases
J. Virol., December 1, 2003; 77(23): 12392 - 12400.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
D. J. Hui, C. R. Bhasker, W. C. Merrick, and G. C. Sen
Viral Stress-inducible Protein p56 Inhibits Translation by Blocking the Interaction of eIF3 with the Ternary Complex eIF2{middle dot}GTP{middle dot}Met-tRNAi
J. Biol. Chem., October 10, 2003; 278(41): 39477 - 39482.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Foeger, E. M. Schmid, and T. Skern
Human Rhinovirus 2 2Apro Recognition of Eukaryotic Initiation Factor 4GI: INVOLVEMENT OF AN EXOSITE
J. Biol. Chem., August 29, 2003; 278(35): 33200 - 33207.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
H. He, T. von der Haar, C. R. Singh, M. Ii, B. Li, A. G. Hinnebusch, J. E. G. McCarthy, and K. Asano
The Yeast Eukaryotic Initiation Factor 4G (eIF4G) HEAT Domain Interacts with eIF1 and eIF5 and Is Involved in Stringent AUG Selection
Mol. Cell. Biol., August 1, 2003; 23(15): 5431 - 5445.
[Abstract] [Full Text] [PDF]


Home page
RNAHome page
C. BERSET, A. ZURBRIGGEN, S. DJAFARZADEH, M. ALTMANN, and H. TRACHSEL
RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiae
RNA, July 1, 2003; 9(7): 871 - 880.
[Abstract] [Full Text] [PDF]


Home page
RNAHome page
J. BARON-BENHAMOU, P. FORTES, T. INADA, T. PREISS, and M. W. HENTZE
The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast
RNA, June 1, 2003; 9(6): 654 - 662.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. Gradi, Y. V. Svitkin, W. Sommergruber, H. Imataka, S. Morino, T. Skern, and N. Sonenberg
Human Rhinovirus 2A Proteinase Cleavage Sites in Eukaryotic Initiation Factors (eIF) 4GI and eIF4GII Are Different
J. Virol., April 15, 2003; 77(8): 5026 - 5029.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
X. Zhao, B. J. Lamphear, D. Xiong, K. Knowlton, and R. E. Rhoads
Protection of Cap-dependent Protein Synthesis in Vivo and in Vitro with an eIF4G-1 Variant Highly Resistant to Cleavage by Coxsackievirus 2A Protease
J. Biol. Chem., February 7, 2003; 278(7): 4449 - 4457.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
V. G. Kolupaeva, I. B. Lomakin, T. V. Pestova, and C. U. T. Hellen
Eukaryotic Initiation Factors 4G and 4A Mediate Conformational Changes Downstream of the Initiation Codon of the Encephalomyocarditis Virus Internal Ribosomal Entry Site
Mol. Cell. Biol., January 15, 2003; 23(2): 687 - 698.
[Abstract] [Full Text] [PDF]


Home page
RNAHome page
J. ZUBEREK, A. WYSLOUCH-CIESZYNSKA, A. NIEDZWIECKA, M. DADLEZ, J. STEPINSKI, W. AUGUSTYNIAK, A.-C. GINGRAS, Z. ZHANG, S. K. BURLEY, N. SONENBERG, et al.
Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: Intein-mediated protein ligation strategy to obtain phosphorylated protein
RNA, January 1, 2003; 9(1): 52 - 61.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
H. Luo, J. Zhang, F. Dastvan, B. Yanagawa, M. A. Reidy, H. M. Zhang, D. Yang, J. E. Wilson, and B. M. McManus
Ubiquitin-Dependent Proteolysis of Cyclin D1 Is Associated with Coxsackievirus-Induced Cell Growth Arrest
J. Virol., December 6, 2002; 77(1): 1 - 9.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
K. Ochs, A. Zeller, L. Saleh, G. Bassili, Y. Song, A. Sonntag, and M. Niepmann
Impaired Binding of Standard Initiation Factors Mediates Poliovirus Translation Attenuation
J. Virol., December 6, 2002; 77(1): 115 - 122.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
J. Ling, S. J. Morley, V. M. Pain, W. F. Marzluff, and D. R. Gallie
The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3
Mol. Cell. Biol., November 15, 2002; 22(22): 7853 - 7867.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
T. V. Pestova and V. G. Kolupaeva
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection
Genes & Dev., November 15, 2002; 16(22): 2906 - 2922.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
B. Han and J.-T. Zhang
Regulation of Gene Expression by Internal Ribosome Entry Sites or Cryptic Promoters: the eIF4G Story
Mol. Cell. Biol., November 1, 2002; 22(21): 7372 - 7384.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
M. P. Byrd, M. Zamora, and R. E. Lloyd
Generation of Multiple Isoforms of Eukaryotic Translation Initiation Factor 4GI by Use of Alternate Translation Initiation Codons
Mol. Cell. Biol., July 1, 2002; 22(13): 4499 - 4511.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
I. Dunand-Sauthier, C. Walker, C. Wilkinson, C. Gordon, R. Crane, C. Norbury, and T. Humphrey
Sum1, a Component of the Fission Yeast eIF3 Translation Initiation Complex, Is Rapidly Relocalized During Environmental Stress and Interacts with Components of the 26S Proteasome
Mol. Biol. Cell, May 1, 2002; 13(5): 1626 - 1640.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. A. Bradley, J. C. Padovan, T. L. Thompson, C. A. Benoit, B. T. Chait, and R. E. Rhoads
Mass Spectrometric Analysis of the N Terminus of Translational Initiation Factor eIF4G-1 Reveals Novel Isoforms
J. Biol. Chem., April 5, 2002; 277(15): 12559 - 12571.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
N. M. Kuyumcu-Martinez, M. Joachims, and R. E. Lloyd
Efficient Cleavage of Ribosome-Associated Poly(A)-Binding Protein by Enterovirus 3C Protease
J. Virol., March 1, 2002; 76(5): 2062 - 2074.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. Zamora, W. E. Marissen, and R. E. Lloyd
Multiple eIF4GI-Specific Protease Activities Present in Uninfected and Poliovirus-Infected Cells
J. Virol., January 1, 2002; 76(1): 165 - 177.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
D. R. Gallie
Cap-Independent Translation Conferred by the 5' Leader of Tobacco Etch Virus Is Eukaryotic Initiation Factor 4G Dependent
J. Virol., December 15, 2001; 75(24): 12141 - 12152.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
M. Ptushkina, K. Berthelot, T. von der Haar, L. Geffers, J. Warwicker, and J. E. G. McCarthy
A second eIF4E protein in Schizosaccharomyces pombe has distinct eIF4G-binding properties
Nucleic Acids Res., November 15, 2001; 29(22): 4561 - 4569.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
A. G. Hinnebusch
Unleashing yeast genetics on a factor-independent mechanism of internal translation initiation
PNAS, November 6, 2001; 98(23): 12866 - 12868.
[Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
I. Ventoso, R. Blanco, C. Perales, and L. Carrasco
HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation
PNAS, October 16, 2001; (2001) 231343498.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
I. K. Ali, L. McKendrick, S. J. Morley, and R. J. Jackson
Activity of the Hepatitis A Virus IRES Requires Association between the Cap-Binding Translation Initiation Factor (eIF4E) and eIF4G
J. Virol., September 1, 2001; 75(17): 7854 - 7863.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. M. Borman, Y. M. Michel, and K. M. Kean
Detailed Analysis of the Requirements of Hepatitis A Virus Internal Ribosome Entry Segment for the Eukaryotic Initiation Factor Complex eIF4F
J. Virol., September 1, 2001; 75(17): 7864 - 7871.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
K. Khaleghpour, A. Kahvejian, G. De Crescenzo, G. Roy, Y. V. Svitkin, H. Imataka, M. O'Connor-McCourt, and N. Sonenberg
Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein
Mol. Cell. Biol., August 1, 2001; 21(15): 5200 - 5213.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
Y. M. Michel, A. M. Borman, S. Paulous, and K. M. Kean
Eukaryotic Initiation Factor 4G-Poly(A) Binding Protein Interaction Is Required for Poly(A) Tail-Mediated Stimulation of Picornavirus Internal Ribosome Entry Segment-Driven Translation but Not for X-Mediated Stimulation of Hepatitis C Virus Translation
Mol. Cell. Biol., July 1, 2001; 21(13): 4097 - 4109.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
C. U.T. Hellen and P. Sarnow
Internal ribosome entry sites in eukaryotic mRNA molecules
Genes & Dev., July 1, 2001; 15(13): 1593 - 1612.
[Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
T. V. Pestova, V. G. Kolupaeva, I. B. Lomakin, E. V. Pilipenko, I. N. Shatsky, V. I. Agol, and C. U. T. Hellen
Molecular mechanisms of translation initiation in eukaryotes
PNAS, June 19, 2001; 98(13): 7029 - 7036.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Virol.Home page
L. Saleh, R. C. Rust, R. Füllkrug, E. Beck, G. Bassili, K. Ochs, and M. Niepmann
Functional interaction of translation initiation factor eIF4G with the foot-and-mouth disease virus internal ribosome entry site
J. Gen. Virol., April 1, 2001; 82(4): 757 - 763.
[Abstract] [Full Text]


Home page
Genes Dev.Home page
A.-C. Gingras, B. Raught, and N. Sonenberg
Regulation of translation initiation by FRAP/mTOR
Genes & Dev., April 1, 2001; 15(7): 807 - 826.
[Full Text]


Home page
Mol. Cell. Biol.Home page
G. C. Scheper, N. A. Morrice, M. Kleijn, and C. G. Proud
The Mitogen-Activated Protein Kinase Signal-Integrating Kinase Mnk2 Is a Eukaryotic Initiation Factor 4E Kinase with High Levels of Basal Activity in Mammalian Cells
Mol. Cell. Biol., February 1, 2001; 21(3): 743 - 754.
[Abstract] [Full Text]


Home page
Cold Spring Harb Symp Quant BiolHome page
I.K. ALI and R.J. JACKSON
The Translation of Capped mRNAs Has an Absolute Requirement for the Central Domain of eIF4G but Not for the Cap-binding Initiation Factor eIF4E
Cold Spring Harb Symp Quant Biol, January 1, 2001; 66(0): 377 - 388.
[Abstract] [PDF]


Home page
Am. J. Pathol.Home page
M. Rothe, Y. Ko, P. Albers, and N. Wernert
Eukaryotic Initiation Factor 3 p110 mRNA Is Overexpressed in Testicular Seminomas
Am. J. Pathol., November 1, 2000; 157(5): 1597 - 1604.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
T. Aragón, S. de la Luna, I. Novoa, L. Carrasco, J. Ortín, and A. Nieto
Eukaryotic Translation Initiation Factor 4GI Is a Cellular Target for NS1 Protein, a Translational Activator of Influenza Virus
Mol. Cell. Biol., September 1, 2000; 20(17): 6259 - 6268.
[Abstract] [Full Text]


Home page
Mol. Cell. Biol.Home page
I. B. Lomakin, C. U. T. Hellen, and T. V. Pestova
Physical Association of Eukaryotic Initiation Factor 4G (eIF4G) with eIF4A Strongly Enhances Binding of eIF4G to the Internal Ribosomal Entry Site of Encephalomyocarditis Virus and Is Required for Internal Initiation of Translation
Mol. Cell. Biol., August 15, 2000; 20(16): 6019 - 6029.
[Abstract] [Full Text]


Home page
Genome ResHome page
L. Aravind and E. V. Koonin
Eukaryote-specific Domains in Translation Initiation Factors: Implications for Translation Regulation and Evolution of the Translation System
Genome Res., August 1, 2000; 10(8): 1172 - 1184.
[Abstract] [Full Text]


Home page
J. Gen. Virol.Home page
L. O. Roberts, A. J. Boxall, L. J. Lewis, G. J. Belsham, and G. E. N. Kass
Caspases are not involved in the cleavage of translation initiation factor eIF4GI during picornavirus infection
J. Gen. Virol., July 1, 2000; 81(7): 1703 - 1707.
[Abstract] [Full Text]


Home page
Microbiol. Mol. Biol. Rev.Home page
M. Gale Jr., S.-L. Tan, and M. G. Katze
Translational Control of Viral Gene Expression in Eukaryotes
Microbiol. Mol. Biol. Rev., June 1, 2000; 64(2): 239 - 280.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
G. N. Rao
Oxidant Stress Stimulates Phosphorylation of eIF4E without an Effect on Global Protein Synthesis in Smooth Muscle Cells. LACK OF EVIDENCE FOR A ROLE OF H2O2 IN ANGIOTENSIN II-INDUCED HYPERTROPHY
J. Biol. Chem., May 26, 2000; 275(22): 16993 - 16999.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Ohlmann, M. Lopez-Lastra, and J.-L. Darlix
An Internal Ribosome Entry Segment Promotes Translation of the Simian Immunodeficiency Virus Genomic RNA
J. Biol. Chem., April 14, 2000; 275(16): 11899 - 11906.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
B. D. Keiper, B. J. Lamphear, A. M. Deshpande, M. Jankowska-Anyszka, E. J. Aamodt, T. Blumenthal, and R. E. Rhoads
Functional Characterization of Five eIF4E Isoforms in Caenorhabditis elegans
J. Biol. Chem., March 31, 2000; 275(14): 10590 - 10596.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. Barco, E. Feduchi, and L. Carrasco
A Stable HeLa Cell Line That Inducibly Expresses Poliovirus 2Apro: Effects on Cellular and Viral Gene Expression
J. Virol., March 1, 2000; 74(5): 2383 - 2392.
[Abstract] [Full Text]


Home page
Mol. Cell. Biol.Home page
M. Stoneley, S. A. Chappell, C. L. Jopling, M. Dickens, M. MacFarlane, and A. E. Willis
c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis
Mol. Cell. Biol., February 15, 2000; 20(4): 1162 - 1169.
[Abstract] [Full Text]


Home page
Mol. Cell. Biol.Home page
D. Goldstaub, A. Gradi, Z. Bercovitch, Z. Grosmann, Y. Nophar, S. Luria, N. Sonenberg, and C. Kahana
Poliovirus 2A Protease Induces Apoptotic Cell Death
Mol. Cell. Biol., February 15, 2000; 20(4): 1271 - 1277.
[Abstract] [Full Text]


Home page
Mol. Cell. Biol.Home page
S. Morino, H. Imataka, Y. V. Svitkin, T. V. Pestova, and N. Sonenberg
Eukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region
Mol. Cell. Biol., January 15, 2000; 20(2): 468 - 477.
[Abstract] [Full Text]


Home page
Mol. Cell. Biol.Home page
S. Henis-Korenblit, N. L. Strumpf, D. Goldstaub, and A. Kimchi
A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation
Mol. Cell. Biol., January 15, 2000; 20(2): 496 - 506.
[Abstract] [Full Text]


Home page
J. Virol.Home page
G. J. Belsham, G. M. McInerney, and N. Ross-Smith
Foot-and-Mouth Disease Virus 3C Protease Induces Cleavage of Translation Initiation Factors eIF4A and eIF4G within Infected Cells
J. Virol., January 1, 2000; 74(1): 272 - 280.
[Abstract] [Full Text]


Home page
J. Virol.Home page
M. Niepel and D. R. Gallie
Identification and Characterization of the Functional Elements within the Tobacco Etch Virus 5' Leader Required for Cap-Independent Translation
J. Virol., November 1, 1999; 73(11): 9080 - 9088.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. M. Elgadi and J. R. Smiley
Picornavirus Internal Ribosome Entry Site Elements Target RNA Cleavage Events Induced by the Herpes Simplex Virus Virion Host Shutoff Protein
J. Virol., November 1, 1999; 73(11): 9222 - 9231.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1995 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement