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Volume 270, Number 38, Issue of September 22, pp. 22440-22444, 1995
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Probing the Conformation of Nucleosome Linker DNA in Situ with Pyrimidine Dimer Formation

(Received for publication, February 14, 1995; and in revised form, July 12, 1995)

John R. Pehrson

The distribution of pyrimidine dimers formed in nucleosomal DNA by irradiation of intact nuclei isolated from rat liver has been examined. Whereas pyrimidine dimer formation in the core region of the nucleosome occurred with peaks at approximately 10-nucleotide intervals as previously reported, the distribution of pyrimidine dimers through the linker region was nearly uniform. This distinction between core and linker DNA was found to be independent of linker length over a range of 38-60 nucleotides. Because there is now ample evidence that DNA curvature is the source of the peaks of pyrimidine dimer formation in the core region, the uniform distribution of pyrimidine dimers observed in the linker region indicates that linker DNA is relatively straight. This suggests that higher order chromatin structure in situ is based on a zigzag chain of nucleosomes.



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This article has been cited by other articles:


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 Nucleic Acids ResHome page
M. Engelhardt
Choreography for nucleosomes: the conformational freedom of the nucleosomal filament and its limitations
Nucleic Acids Res., August 17, 2007; (2007) gkm560v1.
[Abstract] [Full Text] [PDF]


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