Several different oncogenes and growth factors promote G phase progression. Cyclin D1, the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of shortening, the G phase of the cell cycle. The present study demonstrates that transforming mutants of p21 (Ras Val-12, Ras Leu-61) induce the cyclin D1 promoter in human trophoblasts (JEG-3), mink lung epithelial (Mv1.Lu), and in Chinese hamster ovary fibroblast cell lines. Site-directed mutagenesis of AP-1-like sequences at -954 abolished p21-dependent activation of cyclin D1 expression. The AP-1-like sequences were also required for activation of the cyclin D1 promoter by c-Jun. In electrophoretic mobility shift assays using nuclear extracts from cultured cells and primary tissues, several AP-1 proteins (c-Jun, JunB, JunD, and c-Fos) bound the cyclin D1 -954 region. Cyclin D1 promoter activity was stimulated by overexpression of mitogen-activated protein kinase (p41) or c-Ets-2 through the proximal 22 base pairs. Expression of plasmids encoding either dominant negative MAPK (p41) or dominant negatives of ETS activation (Ets-LacZ), antagonized MAPK-dependent induction of cyclin D1 promoter activity. Epidermal growth factor induction of cyclin D1 transcription, through the proximal promoter region, was antagonized by either p41 or Ets-LacZ, suggesting that ETS functions downstream of epidermal growth factor and MAPK in the context of the cyclin D1 promoter. The activation of cyclin D1 transcription by p21provides evidence for cross-talk between the p21 and cell cycle regulatory pathways.

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				A. Sunters, D. P. Thomas, W. A. Yeudall, and A. E. Grigoriadis Accelerated Cell Cycle Progression in Osteoblasts Overexpressing the c-fos Proto-oncogene: INDUCTION OF CYCLIN A AND ENHANCED CDK2 ACTIVITY J. Biol. Chem., March 12, 2004; 279(11): 9882 - 9891. [Abstract] [Full Text] [PDF]

				Y. Huang, J. C. Keen, E. Hager, R. Smith, A. Hacker, B. Frydman, A. L. Valasinas, V. K. Reddy, L. J. Marton, R. A. Casero Jr., et al. Regulation of Polyamine Analogue Cytotoxicity by c-Jun in Human MDA-MB-435 Cancer Cells Mol. Cancer Res., February 1, 2004; 2(2): 81 - 88. [Abstract] [Full Text] [PDF]

				C. A. Lange Making Sense of Cross-Talk between Steroid Hormone Receptors and Intracellular Signaling Pathways: Who Will Have the Last Word? Mol. Endocrinol., February 1, 2004; 18(2): 269 - 278. [Abstract] [Full Text] [PDF]

				M. Shimizu, M. Suzui, A. Deguchi, J. T. E. Lim, and I. B. Weinstein Effects of Acyclic Retinoid on Growth, Cell Cycle Control, Epidermal Growth Factor Receptor Signaling, and Gene Expression in Human Squamous Cell Carcinoma Cells Clin. Cancer Res., February 1, 2004; 10(3): 1130 - 1140. [Abstract] [Full Text] [PDF]

				C. Iavarone, A. Catania, M. J. Marinissen, R. Visconti, M. Acunzo, C. Tarantino, M. S. Carlomagno, C. B. Bruni, J. S. Gutkind, and M. Chiariello The Platelet-derived Growth Factor Controls c-myc Expression through a JNK- and AP-1-dependent Signaling Pathway J. Biol. Chem., December 12, 2003; 278(50): 50024 - 50030. [Abstract] [Full Text] [PDF]

				A. K. Man, L. J. T. Young, J. A. Tynan, J. Lesperance, M. Egeblad, Z. Werb, C. A. Hauser, W. J. Muller, R. D. Cardiff, and R. G. Oshima Ets2-Dependent Stromal Regulation of Mouse Mammary Tumors Mol. Cell. Biol., December 1, 2003; 23(23): 8614 - 8625. [Abstract] [Full Text] [PDF]

				K Yamazaki, K Hanami, T Nagao, A Asoh, I Sugano, and Y Ishida Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear {beta} catenin accumulation and k-ras gene mutation Mol. Pathol., December 1, 2003; 56(6): 336 - 341. [Abstract] [Full Text] [PDF]

				S. K. Agarwal, E. A. Novotny, J. S. Crabtree, J. B. Weitzman, M. Yaniv, A. L. Burns, S. C. Chandrasekharappa, F. S. Collins, A. M. Spiegel, and S. J. Marx Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter PNAS, September 16, 2003; 100(19): 10770 - 10775. [Abstract] [Full Text] [PDF]

				J.-W. Soh and I. B. Weinstein Roles of Specific Isoforms of Protein Kinase C in the Transcriptional Control of Cyclin D1 and Related Genes J. Biol. Chem., September 5, 2003; 278(36): 34709 - 34716. [Abstract] [Full Text] [PDF]

				A. Radu, V. Neubauer, T. Akagi, H. Hanafusa, and M.-M. Georgescu PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1 Mol. Cell. Biol., September 1, 2003; 23(17): 6139 - 6149. [Abstract] [Full Text] [PDF]

				C. Wang, N. Pattabiraman, J. N. Zhou, M. Fu, T. Sakamaki, C. Albanese, Z. Li, K. Wu, J. Hulit, P. Neumeister, et al. Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor {gamma} Expression and Transactivation Mol. Cell. Biol., September 1, 2003; 23(17): 6159 - 6173. [Abstract] [Full Text] [PDF]

				J. T. Fassett, D. Tobolt, C. J. Nelsen, J. H. Albrecht, and L. K. Hansen The Role of Collagen Structure in Mitogen Stimulation of ERK, Cyclin D1 Expression, and G1-S Progression in Rat Hepatocytes J. Biol. Chem., August 22, 2003; 278(34): 31691 - 31700. [Abstract] [Full Text] [PDF]

				S. Tsutsumi, T. Yanagawa, T. Shimura, T. Fukumori, V. Hogan, H. Kuwano, and A. Raz Regulation of Cell Proliferation by Autocrine Motility Factor/Phosphoglucose Isomerase Signaling J. Biol. Chem., August 22, 2003; 278(34): 32165 - 32172. [Abstract] [Full Text] [PDF]

				C. J. Nelsen, D. G. Rickheim, M. M. Tucker, T. J. McKenzie, L. K. Hansen, R. G. Pestell, and J. H. Albrecht Amino Acids Regulate Hepatocyte Proliferation through Modulation of Cyclin D1 Expression J. Biol. Chem., July 3, 2003; 278(28): 25853 - 25858. [Abstract] [Full Text] [PDF]

				Z. Yuan, H. Schellekens, L. Warner, Y. Janssen-Heininger, P. Burch, and N. H. Heintz Reactive Nitrogen Species Block Cell Cycle Re-Entry through Sustained Production of Hydrogen Peroxide Am. J. Respir. Cell Mol. Biol., June 1, 2003; 28(6): 705 - 712. [Abstract] [Full Text] [PDF]

				J. Rajakangas, S. Basu, I. Salminen, and M. Mutanen Adenoma Growth Stimulation by the trans-10, cis-12 Isomer of Conjugated Linoleic Acid (CLA) Is Associated with Changes in Mucosal NF-{kappa}B and Cyclin D1 Protein Levels in the Min Mouse J. Nutr., June 1, 2003; 133(6): 1943 - 1948. [Abstract] [Full Text] [PDF]

				Y.-L. Hu, C. Albanese, R. G. Pestell, and R. B. Jaffe Dual Mechanisms for Lysophosphatidic Acid Stimulation of Human Ovarian Carcinoma Cells J Natl Cancer Inst, May 21, 2003; 95(10): 733 - 740. [Abstract] [Full Text] [PDF]

				M. Razandi, G. Alton, A. Pedram, S. Ghonshani, P. Webb, and E. R. Levin Identification of a Structural Determinant Necessary for the Localization and Function of Estrogen Receptor {alpha} at the Plasma Membrane Mol. Cell. Biol., March 1, 2003; 23(5): 1633 - 1646. [Abstract] [Full Text] [PDF]

				J. A. Diehl, W. Yang, R. A. Rimerman, H. Xiao, and A. Emili Hsc70 Regulates Accumulation of Cyclin D1 and Cyclin D1-Dependent Protein Kinase Mol. Cell. Biol., March 1, 2003; 23(5): 1764 - 1774. [Abstract] [Full Text] [PDF]

				C. Hecquet, G. Lefevre, M. Valtink, K. Engelmann, and F. Mascarelli Activation and Role of MAP Kinase-Dependent Pathways in Retinal Pigment Epithelium Cells: JNK1, P38 Kinase, and Cell Death Invest. Ophthalmol. Vis. Sci., March 1, 2003; 44(3): 1320 - 1329. [Abstract] [Full Text] [PDF]

				J. Gotoh, M. Obata, M. Yoshie, S. Kasai, and K. Ogawa Cyclin D1 over-expression correlates with {beta}-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3{beta} and ERK1/2 in mouse hepatic carcinogenesis Carcinogenesis, March 1, 2003; 24(3): 435 - 442. [Abstract] [Full Text] [PDF]

				A. Ryo, Y.-C. Liou, K. P. Lu, and G. Wulf Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer J. Cell Sci., March 1, 2003; 116(5): 773 - 783. [Abstract] [Full Text] [PDF]

				C. B. Cui, L. F. Cooper, X. Yang, G. Karsenty, and I. Aukhil Transcriptional Coactivation of Bone-Specific Transcription Factor Cbfa1 by TAZ Mol. Cell. Biol., February 1, 2003; 23(3): 1004 - 1013. [Abstract] [Full Text]