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Volume 270, Number 41, Issue of October 13, 1995 pp. 23899-23902
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
A Movable and Regulable Inactivation Function within the Central Region of a Temperature-sensitive p53 Mutant

(Received for publication, June 29, 1995; and in revised form, August 14, 1995)

Jing-Yuan Chuang , ,  Chin-Tarng Lin , ,  Cheng-Wen Wu ,  Young-Sun Lin

p53 is the most frequently mutated gene in human cancer. Naturally occurring mutations of p53 are mainly located within a region containing residues 100-300 and are predominantly of missense type, resulting in loss of the protein's DNA binding activity. Here we show that this type of mutation also represses the p53 N-terminal activation domain. The repression activity is localized in the central region of mutant p53 containing residues 101-318. Interestingly, the central region of a temperature-sensitive mutant p53N247I possesses a movable and regulable inactivation function. It represses other activities present on the same polypeptide chain without strict regard to the configuration of that polypeptide only at the nonpermissive temperature (37 °C) and not at the permissive temperature (30 °C). Furthermore, this mutant p53 region exhibits no other activity, and its function is independent of endogenous p53 status.



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Copyright © 1995 by the American Society for Biochemistry and Molecular Biology.