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Volume 270, Number 44, Issue of November 3, 1995 pp. 26649-26656
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Redundant Domains Contribute to the Transcriptional Activity of the Thyroid Transcription Factor 1

(Received for publication, July 18, 1995)

Mario De Felice , ,  Giuseppe Damante ,  Mariastella Zannini ,  Helen Francis-Lang ,  Roberto Di Lauro

The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing protein implicated in the activation of thyroid-specific gene expression. Here we report that TTF-1 is capable of activating transcription from thyroglobulin and, to a lesser extent, thyroperoxidase gene promoters in nonthyroid cells. Full transcriptional activation of the thyroglobulin promoter by TTF-1 requires the presence of at least two TTF-1 binding sites. TTF-1 activates transcription via two functionally redundant transcriptional activation domains that as suggested by competition experiments, could use a common intermediary factor.



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