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(Received for publication, October 19,
1994; and in revised form, August 23, 1995) Integrin-mediated interactions between cells and the
extracellular matrix play a fundamental role in the development and
function of a variety of tissues by triggering intracellular signals
that regulate gene expression. In this study, mouse mammary epithelial
cells plated on tissue culture plastic were shown to dramatically
up-regulate the steady state levels of mRNA encoding the
Volume 270,
Number 45,
Issue of November 10, 1995 pp. 26794-26801
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
, 
, 
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, 
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, and 
integrin subunits, in contrast
to cells cultured on a basement membrane matrix or cells in
vivo. This pattern of expression was also observed in a mouse
mammary epithelial strain, CID-9 and in other mouse cell lines such as
MMTE cells and K1735-M2 melanoma cells. The control of integrin
expression was mediated at different levels in different cell types. In
K1735-M2 cells, transcription of the integrin gene
was influenced by the substratum, although the levels of integrin
protein remained similar. In mammary epithelial cells, the rates of
integrin gene transcription were similar, but mRNA
and protein levels were higher in cells cultured on plastic than those
on basement membrane. For both cell types, the rate of integrin protein
turnover was nearly identical in cells cultured on either substratum.
Our results demonstrate that extracellular matrix controls the
expression of integrin subunits and that this
regulation is exerted at both transcriptional and post-transcriptional
levels.
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