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(Received for publication, November 3, 1994; and in revised form, December 1, 1994) Using single rat adrenal chromaffin cells, we examined the
coupling of action potential activity to quantal release of
catecholamines by combining perforated patch current-clamp recording
with electrochemical microcarbon fiber amperometry. Chromaffin cells
display steeper dependence of quantal release on action potential
frequency than many nerve terminals, as well as more desynchronized
release following an action potential. Also in contrast to neurons, in
chromaffin cells, a major chemical secretagogue (acetylcholine)
triggers potent quantal release even in the absence of electrical
activity. These findings are consistent with an hypothesis that a major
component of exocytosis from chromaffin cells involves diffusion of
Ca
Volume 270,
Number 8,
Issue of February 24, 1995 pp. 3498-3505
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
to secretion sites which are less well
co-localized with Ca channels than those in nerve
terminals.
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