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Volume 270, Number 9, Issue of March 3, 1995 pp. 4424-4431
©1995 by The American Society for Biochemistry and Molecular Biology, Inc.
Neurons Can Maintain Multiple Classes of Nicotinic Acetylcholine Receptors Distinguished by Different Subunit Compositions

(Received for publication, November 17, 1994)

William G. Conroy,  Darwin K. Berg

Although 10 genes have been cloned encoding putative subunits of neuronal nicotinic acetylcholine receptors, little is known about the variety or subunit composition of such receptors expressed by individual neurons. Chick ciliary ganglion neurons express five of the known genes and assemble a class of synaptic-type receptors collectively containing gene products from three of them: alpha3, beta4, and alpha5. Using subunit-specific monoclonal antibodies, we show here that all of the synaptic-type acetylcholine receptors having alpha3 also have beta4 subunits and vice versa. In addition, most, if not all, of the alpha5 gene product present in fully assembled receptors is associated with both alpha3 and beta4 subunits. Although the receptors may be homogeneous in these respects, only about 20% of them also contain the fourth gene product, beta2, newly identified in the ganglion; essentially all of the neurons express the beta2 gene. No beta2 subunits are found coassembled with the fifth acetylcholine receptor gene product expressed by the neurons, alpha7, which has been shown previously to comprise a class of abundant, nonsynaptic receptors on the cells. The identification of three acetylcholine receptor subtypes distinguished by subunit composition on the same neurons provokes questions about their individual physiological roles.



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Direct Recording of Nicotinic Responses in Presynaptic Nerve Terminals
J. Neurosci., August 1, 1997; 17(15): 5798 - 5806.
[Abstract] [Full Text] [PDF]

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J. M. Kulak, T. A. Nguyen, B. M. Olivera, and J. M. McIntosh
alpha -Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes
J. Neurosci., July 15, 1997; 17(14): 5263 - 5270.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
Q. Du, A. E. Tomkinson, and P. D. Gardner
Transcriptional Regulation of Neuronal Nicotinic Acetylcholine Receptor Genes. A POSSIBLE ROLE FOR THE DNA-BINDING PROTEIN Puralpha
J. Biol. Chem., June 6, 1997; 272(23): 14990 - 14995.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
B. W. Wenger, D. L. Bryant, R. T. Boyd, and D. B. McKay
Evidence for Spare Nicotinic Acetylcholine Receptors and a beta 4 Subunit in Bovine Adrenal Chromaffin Cells: Studies using Bromoacetylcholine, Epibatidine, Cytisine and mAb35
J. Pharmacol. Exp. Ther., May 1, 1997; 281(2): 905 - 913.
[Abstract] [Full Text]

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 Arch NeurolHome page
A. T. Gray, S. T. Krejci, and M. D. Larson
Neuromuscular Blocking Drugs Do Not Alter the Pupillary Light Reflex of Anesthetized Humans
Arch Neurol, May 1, 1997; 54(5): 579 - 584.
[Abstract] [PDF]

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 Mol. Pharmacol.Home page
X. Peng, V. Gerzanich, R. Anand, F. Wang, and J. Lindstrom
Chronic Nicotine Treatment Up-Regulates alpha 3 and alpha 7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y
Mol. Pharmacol., May 1, 1997; 51(5): 776 - 784.
[Abstract] [Full Text]

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 J. Neurosci.Home page
J. McDonough and E. Deneris
beta 43': An Enhancer Displaying Neural-Restricted Activity Is Located in the 3'-Untranslated Exon of the Rat Nicotinic Acetylcholine Receptor beta 4 Gene
J. Neurosci., April 1, 1997; 17(7): 2273 - 2283.
[Abstract] [Full Text] [PDF]

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 J. Neurophysiol.Home page
M. Rogers, L. M. Colquhoun, J. W. Patrick, and J. A. Dani
Calcium Flux Through Predominantly Independent Purinergic ATP and Nicotinic Acetylcholine Receptors
J Neurophysiol, March 1, 1997; 77(3): 1407 - 1417.
[Abstract] [Full Text] [PDF]

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C. B. Bigger, E. A. Casanova, and P. D. Gardner
Transcriptional Regulation of Neuronal Nicotinic Acetylcholine Receptor Genes. FUNCTIONAL INTERACTIONS BETWEEN Sp1 AND THE RAT beta 4 SUBUNIT GENE PROMOTER
J. Biol. Chem., December 20, 1996; 271(51): 32842 - 32848.
[Abstract] [Full Text] [PDF]

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C. M. Flores, R. M. DeCamp, S. Kilo, S. W. Rogers, and K. M. Hargreaves
Neuronal Nicotinic Receptor Expression in Sensory Neurons of the Rat Trigeminal Ganglion: Demonstration of alpha 3beta 4, a Novel Subtype in the Mammalian Nervous System
J. Neurosci., December 15, 1996; 16(24): 7892 - 7901.
[Abstract] [Full Text] [PDF]

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M. S. Levey and M. H. Jacob
Changes in the Regulatory Effects of Cell-Cell Interactions on Neuronal AChR Subunit Transcript Levels after Synapse Formation
J. Neurosci., November 1, 1996; 16(21): 6878 - 6885.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
F. Wang, V. Gerzanich, G. B. Wells, R. Anand, X. Peng, K. Keyser, and J. Lindstrom
Assembly of Human Neuronal Nicotinic Receptor alpha 5 Subunits with alpha 3, beta 2, and beta 4 Subunits
J. Biol. Chem., July 26, 1996; 271(30): 17656 - 17665.
[Abstract] [Full Text] [PDF]

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I. N. Melnikova and P. D. Gardner
The Signal Transduction Pathway Underlying Ion Channel Gene Regulation by Sp1-c-Jun Interactions
J. Biol. Chem., May 25, 2001; 276(22): 19040 - 19045.
[Abstract] [Full Text] [PDF]


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