|
|
|
|||||||
|
|||||||||
(Received for publication, October 26, 1995) We demonstrate that the CD19 receptor associates with the
Volume 271,
Number 13,
Issue of March 29, 1996 pp. 7659-7664
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
1 Integrin Family Surface Adhesion
Molecules VLA-4 and VLA-5 of Human B-cell Precursors Activates CD19
Receptor-associated Protein-tyrosine Kinases
1
family integrin receptors on human B-cell precursors as well as mature
B-lymphocytes, and engagement of the 1 family integrin receptors
with monoclonal antibody homoconjugates leads to rapid activation of
the CD19-associated protein-tyrosine kinases (PTK) and results in
hyperphosphorylation of CD19 on tyrosine residues. Our findings prompt
the hypothesis that homoconjugate-induced integrin clustering may
effect the approximation and, by intermolecular cross-phosphorylation,
activation of the CD19-associated PTK and subsequent tyrosine
phosphorylation of the CD19 receptor. The ability of the 1 family
integrin receptors to transmit a biochemical signal triggering the
CD19-linked multifunctional PTK pathway provides a possible explanation
for the pleiotropic biologic responses generated through adhesive
VLA-4- and VLA-5-mediated contacts.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Berditchevski Complexes of tetraspanins with integrins: more than meets the eye J. Cell Sci., January 12, 2001; 114(23): 4143 - 4151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Sudbeck, X.-P. Liu, R. K. Narla, S. Mahajan, S. Ghosh, C. Mao, and F. M. Uckun Structure-based Design of Specific Inhibitors of Janus Kinase 3 as Apoptosis-inducing Antileukemic Agents Clin. Cancer Res., June 1, 1999; 5(6): 1569 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Damiano, A. E. Cress, L. A. Hazlehurst, A. A. Shtil, and W. S. Dalton Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines Blood, March 1, 1999; 93(5): 1658 - 1667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Horvath, V. Serru, D. Clay, M. Billard, C. Boucheix, and E. Rubinstein CD19 Is Linked to the Integrin-associated Tetraspans CD9, CD81, and CD82 J. Biol. Chem., November 13, 1998; 273(46): 30537 - 30543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Jarvis, J. E. Maguire, and T. W. LeBien Contact Between Human Bone Marrow Stromal Cells and B Lymphocytes Enhances Very Late Antigen-4/Vascular Cell Adhesion Molecule-1-Independent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and ERK2 in Stromal Cells Blood, August 15, 1997; 90(4): 1626 - 1635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-L. Li, M. S. Forman, T. Kurosaki, and E. Pure Syk Is Required for BCR-mediated Activation of p90Rsk, but Not p70S6k, via a Mitogen-activated Protein Kinase-independent Pathway in B Cells J. Biol. Chem., July 18, 1997; 272(29): 18200 - 18208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Otero, S. A. Omori, and R. C. Rickert CD19-dependent Activation of Akt Kinase in B-lymphocytes J. Biol. Chem., January 5, 2001; 276(2): 1474 - 1478. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |