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(Received for publication, September 20, 1995; and in revised form, February 9, 1996) Adapter proteins containing Src homology 2 (SH2) domains link
transmembrane receptor protein-tyrosine kinases to downstream signal
transducing molecules. A family of SH2 containing adapter proteins
including Grb7 and Grb10 has been recently identified. We had
previously shown that Grb10 associates with Ret via its SH2 domain in
an activation-dependent manner (Pandey, A., Duan, H., Di Fiore, P. P.,
and Dixit, V. M.(1995) J. Biol. Chem. 270, 21461-21463).
We now demonstrate that the related adapter molecule Grb7 also
associates with Ret in vitro and in vivo, and that
the binding of the SH2 domain of Grb7 to Ret is direct. This binding is
dependent upon Ret autophosphorylation since Grb7 is incapable of
binding a kinase-defective mutant of Ret. Thus two members of the Grb
family, Grb7 and Grb10, likely relay signals emanating from Ret to
other, as yet, unidentified targets within the cell.
Volume 271,
Number 18,
Issue of May 3, 1996 pp. 10607-10610
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
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