Adipose differentiation is accompanied by changes in cellular morphology, a dramatic accumulation of intracellular lipid and activation of a specific program of gene expression. Using an mRNA differential display technique, we have isolated a novel adipose cDNA, termed adipoQ. The adipoQ cDNA encodes a polypeptide of 247 amino acids with a secretory signal sequence at the amino terminus, a collagenous region (Gly-X-Y repeats), and a globular domain. The globular domain of adipoQ shares significant homology with subunits of complement factor C1q, collagen 1(X), and the brain-specific factor cerebellin. The expression of adipoQ is highly specific to adipose tissue in both mouse and rat. Expression of adipoQ is observed exclusively in mature fat cells as the stromal-vascular fraction of fat tissue does not contain adipoQ mRNA. In cultured 3T3-F442A and 3T3-L1 preadipocytes, hormone-induced differentiation dramatically increases the level of expression for adipoQ. Furthermore, the expression of adipoQ mRNA is significantly reduced in the adipose tissues from obese mice and humans. Whereas the biological function of this polypeptide is presently unknown, the tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue.

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				X. Chen, B. M. Sebastian, and L. E. Nagy Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E621 - E628. [Abstract] [Full Text] [PDF]

				M. Fry, T. D. Hoyda, and A. V. Ferguson Making Sense of It: Roles of the Sensory Circumventricular Organs in Feeding and Regulation of Energy Homeostasis Experimental Biology and Medicine, January 1, 2007; 232(1): 14 - 26. [Abstract] [Full Text] [PDF]

				K. Raun, P. von Voss, C. F. Gotfredsen, V. Golozoubova, B. Rolin, and L. B. Knudsen Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not Diabetes, January 1, 2007; 56(1): 8 - 15. [Abstract] [Full Text] [PDF]

				F. Rodriguez-Pacheco, A. J. Martinez-Fuentes, S. Tovar, L. Pinilla, M. Tena-Sempere, C. Dieguez, J. P. Castano, and M. M. Malagon Regulation of Pituitary Cell Function by Adiponectin Endocrinology, January 1, 2007; 148(1): 401 - 410. [Abstract] [Full Text] [PDF]

				L. Qiao and J. Shao SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein {alpha} Transcriptional Complex J. Biol. Chem., December 29, 2006; 281(52): 39915 - 39924. [Abstract] [Full Text] [PDF]

				M. E. Trujillo and P. E. Scherer Adipose Tissue-Derived Factors: Impact on Health and Disease Endocr. Rev., December 1, 2006; 27(7): 762 - 778. [Abstract] [Full Text] [PDF]

				K. Kadowaki, M. Waguri, I. Nakanishi, Y. Miyashita, M. Nakayama, N. Suehara, T. Funahashi, I. Shimomura, and T. Fujita Adiponectin Concentration in Umbilical Cord Serum Is Positively Associated with the Weight Ratio of Fetus to Placenta J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5090 - 5094. [Abstract] [Full Text] [PDF]

				N. Kubota, T. Yamauchi, K. Tobe, and T. Kadowaki Adiponectin-Dependent and -Independent Pathways in Insulin-Sensitizing and Antidiabetic Actions of Thiazolidinediones Diabetes, December 1, 2006; 55(Supplement_2): S32 - S38. [Full Text] [PDF]

				H. H. Hegener, I-M. Lee, N. R. Cook, P. M. Ridker, and R. Y.L. Zee Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study Clin. Chem., November 1, 2006; 52(11): 2021 - 2027. [Abstract] [Full Text] [PDF]

				R. Nakashima, N. Kamei, K. Yamane, S. Nakanishi, A. Nakashima, and N. Kohno Decreased Total and High Molecular Weight Adiponectin Are Independent Risk Factors for the Development of Type 2 Diabetes in Japanese-Americans J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3873 - 3877. [Abstract] [Full Text] [PDF]

				M. J. Yoon, G. Y. Lee, J.-J. Chung, Y. H. Ahn, S. H. Hong, and J. B. Kim Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator-Activated Receptor {alpha} Diabetes, September 1, 2006; 55(9): 2562 - 2570. [Abstract] [Full Text] [PDF]

				M. M. Haluzik, Z. Lacinova, M. Dolinkova, D. Haluzikova, D. Housa, A. Horinek, Z. Vernerova, T. Kumstyrova, and M. Haluzik Improvement of Insulin Sensitivity after Peroxisome Proliferator-Activated Receptor-{alpha} Agonist Treatment Is Accompanied by Paradoxical Increase of Circulating Resistin Levels Endocrinology, September 1, 2006; 147(9): 4517 - 4524. [Abstract] [Full Text] [PDF]

				C.-H. Kim, P. Pennisi, H. Zhao, S. Yakar, J. B. Kaufman, K. Iganaki, J. Shiloach, P. E. Scherer, M. J. Quon, and D. LeRoith MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E298 - E305. [Abstract] [Full Text] [PDF]

				P. Trayhurn and C. Bing Appetite and energy balance signals from adipocytes Phil Trans R Soc B, July 29, 2006; 361(1471): 1237 - 1249. [Abstract] [Full Text] [PDF]

				Y. Nakano, S. Tajima, A. Yoshimi, H. Akiyama, M. Tsushima, T. Tanioka, T. Negoro, M. Tomita, and T. Tobe A novel enzyme-linked immunosorbent assay specific for high-molecular-weight adiponectin J. Lipid Res., July 1, 2006; 47(7): 1572 - 1582. [Abstract] [Full Text] [PDF]

				Y. Aso, R. Yamamoto, S. Wakabayashi, T. Uchida, K. Takayanagi, K. Takebayashi, T. Okuno, T. Inoue, K. Node, T. Tobe, et al. Comparison of Serum High-Molecular Weight (HMW) Adiponectin With Total Adiponectin Concentrations in Type 2 Diabetic Patients With Coronary Artery Disease Using a Novel Enzyme-Linked Immunosorbent Assay to Detect HMW Adiponectin. Diabetes, July 1, 2006; 55(7): 1954 - 1960. [Abstract] [Full Text] [PDF]

				Y. Takemura, Y. Osuga, T. Yamauchi, M. Kobayashi, M. Harada, T. Hirata, C. Morimoto, Y. Hirota, O. Yoshino, K. Koga, et al. Expression of Adiponectin Receptors and Its Possible Implication in the Human Endometrium Endocrinology, July 1, 2006; 147(7): 3203 - 3210. [Abstract] [Full Text] [PDF]

				Y. Wang, K. S. L. Lam, L. Chan, K. W. Chan, J. B. B. Lam, M. C. Lam, R. C. L. Hoo, W. W. N. Mak, G. J. S. Cooper, and A. Xu Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex J. Biol. Chem., June 16, 2006; 281(24): 16391 - 16400. [Abstract] [Full Text] [PDF]