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(Received for publication, September 18, 1995, and in revised form, November 29, 1995)
and
From the Department of Molecular Physiology and Biophysics,
Vanderbilt University, School of Medicine, Nashville, Tennessee
37232-0615 and the We describe the cloning and analysis of
TAF25, a previously uncharacterized yeast gene that encodes
a yeast TATA-binding protein-associated factor or yTAF of
Mr = 25,000. The gene encoding yTAF25 is a
single copy essential gene, and the protein sequence deduced from
TAF25 exhibits sequence similarity to a metazoan
hTAFII. The results from immunological studies confirm that
yTAF25 is a subunit of a large multiprotein TATA-binding protein-yeast
TATA-binding protein-associated factor complex that contains a subset
of the total number of the yTAFs present in yeast cell extracts. Both
genetic and biochemical analyses demonstrate that yTAF25 can interact
directly with itself. Transcriptional data show that the activity of
the multiprotein complex containing yTAF25 is RNA polymerase
II-specific, thus indicating that TAF25 encodes a bona fide
yeast RNA polymerase II TAF. Hence the protein encoded by
TAF25 has been termed yTAFII25.
Howard Hughes Medical Institute,
Department of Molecular and Cellular Biology, University of California,
Berkeley, California 94720
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