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(Received for publication, February 1, 1996, and in revised form, April 5, 1996)
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and
From the Fibroblast growth factor (FGF)-1 binding to cell
surface receptors stimulates an intracellular signaling pathway that
ultimately promotes the transcriptional activation of specific genes.
We have used a mRNA differential display method to identify
FGF-1-inducible genes in mouse NIH 3T3 fibroblasts. Here, we report
that one of these genes, FGF-regulated (FR)-19, is predicted to encode
a member of the transcriptional enhancer factor (TEF)-1 family of
structurally related DNA-binding proteins. Specifically, the deduced
FR-19 amino acid sequence has ~89, 77, and 68% overall identity to
chicken TEF-1A, mouse TEF-1, and mouse embryonic TEA domain-containing
factor, respectively. Gel mobility shift experiments indicate that
FR-19, like TEF-1, can bind the GT-IIC motif found in the SV40
enhancer. The FR-19 gene maps in the distal region of mouse chromosome
6, and analysis of several FR-19 cDNA clones indicates that at
least two FR-19 isoforms may be expressed from this locus. FGF-1
induction of FR-19 mRNA expression in mouse fibroblasts is first
detectable at 4 h after FGF-1 addition and is dependent on
de novo RNA and protein synthesis. FGF-2, calf serum,
platelet-derived growth factor-BB, and phorbol 12-myristate 13-acetate
can also induce FR-19 mRNA levels. We have also found that FR-19
mRNA expression increases during mouse C2C12 myoblast
differentiation in vitro. The FR-19 gene is expressed
in vivo in a tissue-specific manner, with a
relatively high level detected in lung. These results indicate
that increased expression of a TEF-1-related protein may be important
for both mitogen-stimulated fibroblast proliferation and skeletal
muscle cell differentiation.
Department of Molecular Biology, Holland
Laboratory, American Red Cross, Rockville, Maryland 20855, the
Mammalian Genetics Laboratory¶ , ABL-Basic Research Program,
National Cancer Institute-Frederick Cancer Research and Development
Center, Frederick, Maryland 21702, and the 
Department of
Biochemistry and Molecular Biology, George Washington University
Medical Center, Washington, D. C. 20037
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