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(Received for publication, February 27, 1996, and in revised form, April 23, 1996)
From the Department of Biochemistry, Purdue University, West
Lafayette, Indiana 47907
Leptin, the product of the ob gene,
controls food-intake and weight loss in the ob mouse.
Although the target(s) of the circulating leptin is presumed to be the
brain which then orchestrates food-intake and weight loss, how leptin
functions in the process of weight loss is unknown. In this report, we
present evidence that ob gene expression in cultured cells
suppresses acetyl-CoA carboxylase gene expression and lipid synthesis
which are induced by hormone treatment. This is the first example in
which leptin has been found to suppress defined biochemical reactions
that contribute to lipid accumulation without the participation of the
brain.
Volume 271, Number 24,
Issue of June 14, 1996
pp. 13939-13942
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
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