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Volume 271, Number 24, Issue of June 14, 1996 pp. 14062-14066
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

Normal Development of Mice Lacking Metablastin (P19), a Phosphoprotein Implicated in Cell Cycle Regulation

(Received for publication, December 22, 1995, and in revised form, March 22, 1996)

Ulrich K. Schubart Dagger § , Jinghua Yu Dagger § , Jose A. Amat par , Zhi-qin Wang '' , Michael K. Hoffmann '' and Winfried Edelmann '''

From the Departments of Dagger  Medicine, § Molecular Pharmacology, par  Neurology, and ''' Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461 and the '' Department of Immunology, New York Medical College, Valhalla,  New York 10595

Metablastin, also called P19, stathmin, prosolin, Lap18, and oncoprotein18, is a highly conserved cytosolic protein that undergoes extracellular factor- and cell cycle-regulated serine phosphorylation and developmentally regulated expression in mammals. It has been implicated in a variety of cellular functions including growth and differentiation, and recent evidence suggests an involvement in cell cycle control. To explore its potential role in mammalian development, we have disrupted the gene encoding metablastin by gene targeting in mice. The metablastin null mutants have no overt phenotype regarding development, growth rate, behavior, T cell maturation, or fertility and do not exhibit an increased predisposition to tumors. SCG10, a protein closely related in structure to metablastin, shows no compensatory up-regulation in metablastin-/- mice. Although the data suggest that metablastin is not essential for mammalian development, the knockout mice should prove valuable in exploring the role of this protein in cell cycle regulation.


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