| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, December 13, 1995, and in revised form, March 25, 1996)
From the The biological effects of hepatocyte growth
factor/scatter factor are mediated by autophosphorylation of its
receptor, the Met tyrosine kinase, on two carboxyl-terminal tyrosines.
These phosphotyrosines
(Y1349VHVNATY1356VNV) are multifunctional
docking sites for several effectors. Grb2, the adaptor for the Ras
guanyl-nucleotide exchanger SOS, binds to Tyr1356 in the
YV
Volume 271, Number 24,
Issue of June 14, 1996
pp. 14119-14123
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
DIFFERENTIAL EFFECTS ON TRANSFORMATION AND MOTILITY
,
,
,
,''
,
,
,
and
Department of Biomedical Sciences and Human
Oncology, Università di Torino, 10126 Torino, Italy and '' Ludwig
Institute for Cancer Research, London W1P 8BT, United Kingdom
V motif. By site-directed mutagenesis we either
abrogated or duplicated the Grb2 consensus, without interfering with
the other effectors. Loss of the link with Grb2 severely impaired
transformation. The same mutation, however, had no effect on the
``scattering'' response, indicating that the level of signal which
can be reached by Grb2-independent routes is permissive for motility.
Duplication of the Grb2 binding site enhanced transformation and left
motility unchanged. Thus, two Met-mediated biological responses,
motility and growth, can be dissociated on the basis of their
differential requirement for a direct link with Ras.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Garzotto, P. Giacobini, T. Crepaldi, A. Fasolo, and S. De Marchis Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling J. Neurosci., June 4, 2008; 28(23): 5901 - 5909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Seiden-Long, R. Navab, W. Shih, M. Li, J. Chow, C. Q. Zhu, N. Radulovich, C. Saucier, and M.-S. Tsao Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells Carcinogenesis, March 1, 2008; 29(3): 647 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kondo, N. Hirayama, Y. Sugito, M. Shono, T. Tanaka, and N. Kitamura Coupling of Grb2 to Gab1 Mediates Hepatocyte Growth Factor-induced High Intensity ERK Signal Required for Inhibition of HepG2 Hepatoma Cell Proliferation J. Biol. Chem., January 18, 2008; 283(3): 1428 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Zeng, M.-Z. Zhang, A. B. Singh, R. Zent, and R. C. Harris ErbB4 Isoforms Selectively Regulate Growth Factor induced Madin-Darby Canine Kidney Cell Tubulogenesis Mol. Biol. Cell, November 1, 2007; 18(11): 4446 - 4456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Li, M. Lorinczi, K. Ireton, and L. A. Elferink Specific Grb2-mediated Interactions Regulate Clathrin-dependent Endocytosis of the cMet-tyrosine Kinase J. Biol. Chem., June 8, 2007; 282(23): 16764 - 16775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Crepaldi, F. Bersani, C. Scuoppo, P. Accornero, C. Prunotto, R. Taulli, P. E. Forni, C. Leo, R. Chiarle, J. Griffiths, et al. Conditional Activation of MET in Differentiated Skeletal Muscle Induces Atrophy J. Biol. Chem., March 2, 2007; 282(9): 6812 - 6822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ishibe, J. E. Haydu, A. Togawa, A. Marlier, and L. G. Cantley Cell Confluence Regulates Hepatocyte Growth Factor-Stimulated Cell Morphogenesis in a {beta}-Catenin-Dependent Manner Mol. Cell. Biol., December 15, 2006; 26(24): 9232 - 9243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mood, C. Saucier, Y.-S. Bong, H.-S. Lee, M. Park, and I. O. Daar Gab1 Is Required for Cell Cycle Transition, Cell Proliferation, and Transformation Induced by an Oncogenic Met Receptor Mol. Biol. Cell, September 1, 2006; 17(9): 3717 - 3728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. McGill, R. Haq, E. K. Nishimura, and D. E. Fisher c-Met Expression Is Regulated by Mitf in the Melanocyte Lineage J. Biol. Chem., April 14, 2006; 281(15): 10365 - 10373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Stella, L. Trusolino, S. Pennacchietti, and P. M. Comoglio Negative Feedback Regulation of Met-Dependent Invasive Growth by Notch Mol. Cell. Biol., May 15, 2005; 25(10): 3982 - 3996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Basar, Y. Shen, and K. Ireton Redundant Roles for Met Docking Site Tyrosines and the Gab1 Pleckstrin Homology Domain in InlB-Mediated Entry of Listeria monocytogenes Infect. Immun., April 1, 2005; 73(4): 2061 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hov, R. U. Holt, T. B. Ro, U.-M. Fagerli, H. Hjorth-Hansen, V. Baykov, J. G. Christensen, A. Waage, A. Sundan, and M. Borset A Selective c-Met Inhibitor Blocks an Autocrine Hepatocyte Growth Factor Growth Loop in ANBL-6 Cells and Prevents Migration and Adhesion of Myeloma Cells Clin. Cancer Res., October 1, 2004; 10(19): 6686 - 6694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Higuchi, T. Orita, K. Katsuya, Y. Yamasaki, K. Akiyama, H. Li, T. Yamamoto, Y. Saito, and M. Nakamura MUC20 Suppresses the Hepatocyte Growth Factor-Induced Grb2-Ras Pathway by Binding to a Multifunctional Docking Site of Met Mol. Cell. Biol., September 1, 2004; 24(17): 7456 - 7468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Balkovetz, E. R. Gerrard Jr., S. Li, D. Johnson, J. Lee, J. W. Tobias, K. K. Rogers, R. W. Snyder, and J. H. Lipschutz Gene expression alterations during HGF-induced dedifferentiation of a renal tubular epithelial cell line (MDCK) using a novel canine DNA microarray Am J Physiol Renal Physiol, April 1, 2004; 286(4): F702 - F710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Saucier, H. Khoury, K.-M. V. Lai, P. Peschard, D. Dankort, M. A. Naujokas, J. Holash, G. D. Yancopoulos, W. J. Muller, T. Pawson, et al. The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis PNAS, February 24, 2004; 101(8): 2345 - 2350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Shinomiya and G. F. Vande Woude Suppression of Met Expression: A Possible Cancer Treatment: Commentary re: S. J. Kim et al., Reduced c-Met Expression by an Adenovirus Expressing a c-Met Ribozyme Inhibits Tumorigenic Growth and Lymph Node Metastases of PC3-LN4 Prostate Tumor Cells in an Orthotopic Nude Mouse Model. Clin. Cancer Res., 14: 5161-5170, 2003. Clin. Cancer Res., November 1, 2003; 9(14): 5085 - 5090. [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Recio and G. Merlino Hepatocyte Growth Factor/Scatter Factor Induces Feedback Up-Regulation of CD44v6 in Melanoma Cells through Egr-1 Cancer Res., April 1, 2003; 63(7): 1576 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Palka, M. Park, and N. K. Tonks Hepatocyte Growth Factor Receptor Tyrosine Kinase Met Is a Substrate of the Receptor Protein-tyrosine Phosphatase DEP-1 J. Biol. Chem., February 14, 2003; 278(8): 5728 - 5735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Uzumcu, S. D. Westfall, K. A. Dirks, and M. K. Skinner Embryonic Testis Cord Formation and Mesonephric Cell Migration Requires the Phosphotidylinositol 3-Kinase Signaling Pathway Biol Reprod, December 1, 2002; 67(6): 1927 - 1935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ieraci, P. E. Forni, and C. Ponzetto Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development PNAS, November 12, 2002; 99(23): 15200 - 15205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. I. Taher, E. P. M. Tjin, E. A. Beuling, J. Borst, M. Spaargaren, and S. T. Pals c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination J. Immunol., October 1, 2002; 169(7): 3793 - 3800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang, Z. Li, E. M. Messing, and G. Wu Activation of Ras/Erk Pathway by a Novel MET-interacting Protein RanBPM J. Biol. Chem., September 20, 2002; 277(39): 36216 - 36222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Purdie, G. St.J. Whitley, A. P. Johnstone, and J. E. Cartwright Hepatocyte growth factor-induced endothelial cell motility is mediated by the upregulation of inducible nitric oxide synthase expression Cardiovasc Res, June 1, 2002; 54(3): 659 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mildner, L. Eckhart, B. Lengauer, and E. Tschachler Hepatocyte Growth Factor/Scatter Factor Inhibits UVB-induced Apoptosis of Human Keratinocytes but Not of Keratinocyte-derived Cell Lines via the Phosphatidylinositol 3-Kinase/AKT Pathway J. Biol. Chem., April 12, 2002; 277(16): 14146 - 14152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grisendi, B. Chambraud, I. Gout, P. M. Comoglio, and T. Crepaldi Ligand-regulated Binding of FAP68 to the Hepatocyte Growth Factor Receptor J. Biol. Chem., November 30, 2001; 276(49): 46632 - 46638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Dong, Z. Chen, Z.-Y. Li, N. T. Yeh, C. C. Bancroft, and C. Van Waes Hepatocyte Growth Factor/Scatter Factor-induced Activation of MEK and PI3K Signal Pathways Contributes to Expression of Proangiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor in Head and Neck Squamous Cell Carcinoma Cancer Res., August 1, 2001; 61(15): 5911 - 5918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Catizone, G. Ricci, and M. Galdieri Expression and Functional Role of Hepatocyte Growth Factor Receptor (C-MET) during Postnatal Rat Testis Development Endocrinology, May 1, 2001; 142(5): 1828 - 1834. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. TRUSOLINO, S. CAVASSA, P. ANGELINI, M. Ò, A. BERTOTTI, P. M. COMOGLIO, and C. BOCCACCIO HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity FASEB J, August 1, 2000; 14(11): 1629 - 1640. [Abstract] [Full Text]
|
|
|
|
 |
|
 U. Schaeper, N. H. Gehring, K. P. Fuchs, M. Sachs, B. Kempkes, and W. Birchmeier Coupling of Gab1 to c-Met, Grb2, and Shp2 Mediates Biological Responses J. Cell Biol., June 26, 2000; 149(7): 1419 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Beilmann, G. F. Vande Woude, H.-P. Dienes, and P. Schirmacher Hepatocyte growth factor-stimulated invasiveness of monocytes Blood, June 15, 2000; 95(12): 3964 - 3969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Raptis, H. L. Brownell, A. M. Vultur, G. M. Ross, E. Tremblay, and B. E. Elliott Specific Inhibition of Growth Factor-stimulated Extracellular Signal-regulated Kinase 1 and 2 Activation in Intact Cells by Electroporation of a Growth Factor Receptor-binding Protein 2-Src Homology 2 Binding Peptide Cell Growth Differ., June 1, 2000; 11(6): 293 - 303. [Abstract] [Full Text]
|
|
|
|
|
|
D. Sakkab, M. Lewitzky, G. Posern, U. Schaeper, M. Sachs, W. Birchmeier, and S. M. Feller Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein Gab1 and the Adapter Protein CRKL J. Biol. Chem., April 6, 2000; 275(15): 10772 - 10778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Otsuka, J. Jakubczak, W. Vieira, D. P. Bottaro, D. Breckenridge, W. J. Larochelle, and G. Merlino Disassociation of Met-Mediated Biological Responses In Vivo: the Natural Hepatocyte Growth Factor/Scatter Factor Splice Variant NK2 Antagonizes Growth but Facilitates Metastasis Mol. Cell. Biol., March 15, 2000; 20(6): 2055 - 2065. [Abstract] [Full Text]
|
|
|
|
|
|
A. Bardelli, P. Longati, T. A. Williams, S. Benvenuti, and P. M. Comoglio A Peptide Representing the Carboxyl-terminal Tail of the Met Receptor Inhibits Kinase Activity and Invasive Growth J. Biol. Chem., October 8, 1999; 274(41): 29274 - 29281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Catizone, G. Ricci, V. Arista, A. Innocenzi, and M. Galdieri Hepatocyte Growth Factor and c-MET Are Expressed in Rat Prepuberal Testis Endocrinology, July 1, 1999; 140(7): 3106 - 3113. [Abstract] [Full Text]
|
|
|
|
|
|
T. Tamatani, K. Hattori, A. Iyer, K. Tamatani, and R. Oyasu Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro Carcinogenesis, June 1, 1999; 20(6): 957 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Y. Park and M. J. Hayman The Tyrosines in the Bidentate Motif of the env-sea Oncoprotein Are Essential for Cell Transformation and Are Binding Sites for Grb2 and the Tyrosine Phosphatase SHP-2 J. Biol. Chem., March 12, 1999; 274(11): 7583 - 7590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tulasne, R. Paumelle, K. M. Weidner, B. Vandenbunder, and V. Fafeur The Multisubstrate Docking Site of the MET Receptor Is Dispensable for MET-mediated RAS Signaling and Cell Scattering Mol. Biol. Cell, March 1, 1999; 10(3): 551 - 565. [Abstract] [Full Text]
|
|
|
|
|
|
D. Ronen, R. T. Altstock, M. Firon, L. Mittelman, T. Sobe, J. H. Resau, G. F. Vande Woude, and I. Tsarfaty Met-HGF/SF Mediates Growth Arrest and Differentiation in T47D Breast Cancer Cells Cell Growth Differ., February 1, 1999; 10(2): 131 - 140. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Deakin and M Lyon Differential regulation of hepatocyte growth factor/scatter factor by cell surface proteoglycans and free glycosaminoglycan chains J. Cell Sci., January 6, 1999; 112(12): 1999 - 2009. [Abstract] [PDF]
|
|
|
|
|
|
N. Rahimi, W. Hung, E. Tremblay, R. Saulnier, and B. Elliott c-Src Kinase Activity Is Required for Hepatocyte Growth Factor-induced Motility and Anchorage-independent Growth of Mammary Carcinoma Cells J. Biol. Chem., December 11, 1998; 273(50): 33714 - 33721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chin, G. Merlino, and R. A. DePinho Malignant melanoma: modern black plague and genetic black box Genes & Dev., November 15, 1998; 12(22): 3467 - 3481. [Full Text]
|
|
|
|
|
|
A. Khwaja, K. Lehmann, B. M. Marte, and J. Downward Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway J. Biol. Chem., July 24, 1998; 273(30): 18793 - 18801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Paciucci, M. R. Vila, T. Adell, V. M. Diaz, M. Tora, T. Nakamura, and F. X. Real Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System and Redistribution of E-Cadherin Are Associated with Hepatocyte Growth Factor-Induced Motility of Pancreas Tumor Cells Overexpressing Met Am. J. Pathol., July 1, 1998; 153(1): 201 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Maina, M. C. Hilton, C. Ponzetto, A. M. Davies, and R. Klein Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons Genes & Dev., December 15, 1997; 11(24): 3341 - 3350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Giordano, A. Bardelli, Z. Zhen, S. Menard, C. Ponzetto, and P. M. Comoglio A point mutation in the MET oncogene abrogates metastasis without affecting transformation PNAS, December 9, 1997; 94(25): 13868 - 13872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Fixman, M. Holgado-Madruga, L. Nguyen, D. M. Kamikura, T. M. Fournier, A. J. Wong, and M. Park Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1 J. Biol. Chem., August 8, 1997; 272(32): 20167 - 20172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Skouteris and C. Schroder Cytosolic phospholipase A2 is activated by the hepatocyte growth factor receptor-kinase in Madin Darby canine kidney cells J. Cell Sci., January 7, 1997; 110(14): 1655 - 1663. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
