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(Received for publication, February 6, 1996)
From the Department of Cardiology, Children's Hospital, and
§ Department of Cell Biology and Pediatrics, Harvard
Medical School, Boston, Massachusetts 02115
The mammalian achaete-scute homolog 1 (MASH1)
protein is required for the early development of the nervous system.
However, the molecular and biochemical mechanism by which MASH1 acts to
determine neurogenesis are still unknown. The myocyte enhancer factor
2A (MEF2A) is a MADS transcription factor that is essential for the
specification and differentiation of the muscle lineage. Here we show
that MEF2A and MASH1 are coordinately induced during the
differentiation of the teratocarcinoma cell line P19 along a neuronal
lineage and that in transient transfection assays, MEF2A and MASH1
cooperatively activate gene expression. This cooperativity appears to
be due to a specific physical interaction between MEF2A and MASH1.
Taken together, these findings suggest that MASH1 via a cooperative
interaction with MEF2A may regulate the expression of specific genes
that are critical for neuronal differentiation.
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