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(Received for publication, December 29, 1995, and in revised form, March 14, 1996)
From the Specific phosphoproteins are targets of numerous
extracellular signals received by astrocytes. One such target, which we
previously described, is PEA-15, a protein kinase C substrate
associated with microtubules. Two cDNAs differing in the length of
their 3
Volume 271, Number 25,
Issue of June 21, 1996
pp. 14800-14806
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
,
,
,
,
,
and
INSERM U114 and Chaire de Neuropharmacologie
du Collège de France, 75231 Paris Cedex 05, France and the
CNRS UPR2212, Institut Alfred Fessard,
91998 Gif-sur-Yvette, France
-untranslated region (3UTR) were cloned from a mouse
astrocytic library. Accordingly, Northern blots revealed two
transcripts (1.7 and 2.5 kilobase pairs) abundant brain regions but
also found in peripheral tissues. PEA-15-deduced protein sequence (130 amino acids) shared no similarity with known proteins but is 96%
identical to its human counterpart. In addition, several regions of the
3UTR share more than 90% identity between mouse and human. Different
potential regulatory sequences are found in the 3UTR, which also
completely includes the proto-oncogene MAT1. The high level of
conservation of both the coding and the untranslated regions and the
differential tissular distribution of the two transcripts of this major
brain phosphoprotein suggest that not only the protein but also the
3UTR of PEA-15 mRNA play a role in astrocytic functions.
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