|
|
|
|||||||
|
|||||||||
(Received for publication, February 1, 1996, and in revised form, April 1, 1996)
From the Prolactin (PRL) is essential for progesterone
biosynthesis and luteal cell hypertrophy of the rat corpus luteum
during pregnancy. Both the long and short form of the PRL receptor have
been identified in the corpus luteum of pregnant rat. The long form has
been shown to transduce PRL signal in other cells, whereas no
information is available on the role of the short form, especially in
the corpus luteum. In the present study, we have cloned a rat
ovarian-specific phosphoprotein, PRAP (
Volume 271, Number 26,
Issue of June 28, 1996
pp. 15602-15607
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
,
Department of Physiology & Biophysics,
University of Illinois, Chicago, Illinois 60612 and the
§ Department of Biochemistry, Molecular Biology, and
Cell Biology, Northwestern University, Evanston, Illinois 60208
RL
eceptor ssociated rotein), which
has no significant homology to other known proteins. We have
demonstrated that this protein is immunoprecipitated by anti-PRL
receptor and anti-phosphotyrosine antibodies. To determine whether PRAP
associates with either the long or the short form of the PRL receptor,
fusion proteins with glutathione S-transferase containing
the cytoplasmic domain of the long or short form of the PRL receptor
were produced, purified, and incubated with luteal proteins. Our
results indicate that PRAP preferentially binds to the short form of
the PRL receptor. Thus, the long form and short forms of the PRL
receptor may signal through distinct pathways. These data provide
evidence for the involvement of a novel protein in PRL signal
transduction and suggest that PRAP may contribute to the luteotropic
effects of PRL on the corpus luteum during pregnancy.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Shehu, J. Mao, G. B. Gibori, J. Halperin, J. Le, Y. Sangeeta Devi, B. Merrill, H. Kiyokawa, and G. Gibori Prolactin Receptor-Associated Protein/17{beta}-Hydroxysteroid Dehydrogenase Type 7 Gene (Hsd17b7) Plays a Crucial Role in Embryonic Development and Fetal Survival Mol. Endocrinol., October 1, 2008; 22(10): 2268 - 2277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Day, H. J Tutill, A. Purohit, and M. J Reed Design and validation of specific inhibitors of 17{beta}-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis Endocr. Relat. Cancer, September 1, 2008; 15(3): 665 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suzuki, F. Schirra, S. M. Richards, R. V. Jensen, and D. A. Sullivan Estrogen and Progesterone Control of Gene Expression in the Mouse Meibomian Gland Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 1797 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Stocco, C. Telleria, and G. Gibori The Molecular Control of Corpus Luteum Formation, Function, and Regression Endocr. Rev., February 1, 2007; 28(1): 117 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ohnesorg, B. Keller, M. H. de Angelis, and J. Adamski Transcriptional regulation of human and murine 17{beta}-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. J. Mol. Endocrinol., August 1, 2006; 37(1): 185 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Pangas, X. Li, E. J. Robertson, and M. M. Matzuk Premature Luteinization and Cumulus Cell Defects in Ovarian-Specific Smad4 Knockout Mice Mol. Endocrinol., June 1, 2006; 20(6): 1406 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Labrie, V Luu-The, A Belanger, S-X Lin, J Simard, G Pelletier, and C Labrie Is dehydroepiandrosterone a hormone? J. Endocrinol., November 1, 2005; 187(2): 169 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Risk, A. Shehu, J. Mao, C. O. Stocco, L. T. Goldsmith, J. M. Bowen-Shauver, and G. Gibori Cloning and Characterization of a 5' Regulatory Region of the Prolactin Receptor-Associated Protein/17{beta} Hydroxysteroid Dehydrogenase 7 Gene Endocrinology, June 1, 2005; 146(6): 2807 - 2816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Foyouzi, Z. Cai, Y. Sugimoto, and C. Stocco Changes in the Expression of Steroidogenic and Antioxidant Genes in the Mouse Corpus Luteum During Luteolysis Biol Reprod, May 1, 2005; 72(5): 1134 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Payne and D. B. Hales Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones Endocr. Rev., December 1, 2004; 25(6): 947 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Marijanovic, D. Laubner, G. Moller, C. Gege, B. Husen, J. Adamski, and R. Breitling Closing the Gap: Identification of Human 3-Ketosteroid Reductase, the Last Unknown Enzyme of Mammalian Cholesterol Biosynthesis Mol. Endocrinol., September 1, 2003; 17(9): 1715 - 1725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Husen, J. Adamski, A. Bruns, D. Deluca, K. Fuhrmann, G. Moller, I. Schwabe, and A. Einspanier Characterization of 17{beta}-Hydroxysteroid Dehydrogenase Type 7 in Reproductive Tissues of the Marmoset Monkey Biol Reprod, June 1, 2003; 68(6): 2092 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Labrie, V. Luu-The, C. Labrie, A. Belanger, J. Simard, S.-X. Lin, and G. Pelletier Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone Endocr. Rev., April 1, 2003; 24(2): 152 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Lu, P. Scott, G. J. Strous, and L. A. Schuler Multiple Internalization Motifs Differentially Used by Prolactin Receptor Isoforms Mediate Similar Endocytic Pathways Mol. Endocrinol., November 1, 2002; 16(11): 2515 - 2527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. G. Selvaraj, E. Omi, G. Gibori, and M. C. Rao Janus Kinase 2 (JAK2) Regulates Prolactin-Mediated Chloride Transport in Mouse Mammary Epithelial Cells through Tyrosine Phosphorylation of Na+-K+-2Cl- Cotransporter Mol. Endocrinol., December 1, 2000; 14(12): 2054 - 2065. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy Prolactin: Structure, Function, and Regulation of Secretion Physiol Rev, October 1, 2000; 80(4): 1523 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nokelainen, H. Peltoketo, M. Mustonen, and P. Vihko Expression of Mouse 17{beta}-Hydroxysteroid Dehydrogenase/17-Ketosteroid Reductase Type 7 in the Ovary, Uterus, and Placenta: Localization from Implantation to Late Pregnancy Endocrinology, February 1, 2000; 141(2): 772 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Russell and J. S. Richards Differentiation-Dependent Prolactin Responsiveness and Stat (Signal Transducers and Activators of Transcription) Signaling in Rat Ovarian Cells Mol. Endocrinol., December 1, 1999; 13(12): 2049 - 2064. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. G. Mensah-Nyagan, J.-L. Do-Rego, D. Beaujean, V. Luu-The, G. Pelletier, and H. Vaudry Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System Pharmacol. Rev., March 1, 1999; 51(1): 63 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nokelainen, H. Peltoketo, R. Vihko, and P. Vihko Expression Cloning of a Novel Estrogenic Mouse 17{beta}-Hydroxysteroid Dehydrogenase/ 17-Ketosteroid Reductase (m17HSD7), Previously Described as a Prolactin Receptor-Associated Protein (PRAP) in Rat Mol. Endocrinol., July 1, 1998; 12(7): 1048 - 1059. [Abstract] [Full Text]
|
|
|
|
|
|
C. Bole-Feysot, V. Goffin, M. Edery, N. Binart, and P. A. Kelly Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice Endocr. Rev., June 1, 1998; 19(3): 225 - 268. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Telleria, T. G. Parmer, L. Zhong, D. L. Clarke, C. T. Albarracin, W. R. Duan, D. I. H. Linzer, and G. Gibori The Different Forms of the Prolactin Receptor in the Rat Corpus Luteum: Developmental Expression and Hormonal Regulation in Pregnancy Endocrinology, November 1, 1997; 138(11): 4812 - 4820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Schuler, R. J. Nagel, J. Gao, N. D. Horseman, and M. A. Kessler Prolactin Receptor Heterogeneity in Bovine Fetal and Maternal Tissues Endocrinology, August 1, 1997; 138(8): 3187 - 3194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Duan, T. G. Parmer, C. T. Albarracin, L. Zhong, and G. Gibori PRAP, a Prolactin Receptor Associated Protein: Its Gene Expression and Regulation in the Corpus Luteum Endocrinology, August 1, 1997; 138(8): 3216 - 3221. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |