HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Graham, C. Articles by Wistow, G. Search for Related Content PubMed PubMed Citation Articles by Graham, C. Articles by Wistow, G. Social Bookmarking                      What's this?

Volume 271, Number 26, Issue of June 28, 1996 pp. 15623-15628
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

---

A Retinaldehyde Dehydrogenase as a Structural Protein in a Mammalian Eye Lens
GENE RECRUITMENT OF -CRYSTALLIN

(Received for publication, February 14, 1996, and in revised form, April 2, 1996)

From the Section on Molecular Structure and Function, Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730

-Crystallin is a taxon-specific crystallin, a major component of the eye lens in elephant shrews (Macroscelidea). Sequence analysis of -crystallin from two genera of elephant shrews and expression of recombinant -crystallin show that the protein is a cytoplasmic (class 1) aldehyde dehydrogenase (ALDH1, EC) with activity for the oxidation of retinaldehyde to retinoic acid. Unlike many other mammals, elephant shrews have two ALDH1 genes. One encodes ALDH1/-crystallin which, in addition to its very high expression in lens, is also the predominant form of ALDH1 expressed in other parts of the eye. The second gene encodes a ``non-lens'' ALDH1 (ALDH1-nl) which is the predominant form expressed in liver. This pattern of tissue preference contrasts with other mammals which make use of the same major ALDH1 transcript in both ocular and non-ocular tissues. Thus the gene recruitment of ALDH1/-crystallin as a structural protein in elephant shrew lenses is associated with its collateral recruitment as the major form of ALDH1 expressed in other parts of the eye.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				N. Lassen, J. B. Bateman, T. Estey, J. R. Kuszak, D. W. Nees, J. Piatigorsky, G. Duester, B. J. Day, J. Huang, L. M. Hines, et al. Multiple and Additive Functions of ALDH3A1 and ALDH1A1: CATARACT PHENOTYPE AND OCULAR OXIDATIVE DAMAGE IN Aldh3a1(-/-)/Aldh1a1(-/-) KNOCK-OUT MICE J. Biol. Chem., August 31, 2007; 282(35): 25668 - 25676. [Abstract] [Full Text] [PDF]

				D. W. Nees, E. F. Wawrousek, W. G. Robison Jr, and J. Piatigorsky Structurally Normal Corneas in Aldehyde Dehydrogenase 3a1-Deficient Mice Mol. Cell. Biol., February 1, 2002; 22(3): 849 - 855. [Abstract] [Full Text] [PDF]

				E. Carosa, Z. Kozmik, J. E. Rall, and J. Piatigorsky Structure and Expression of the Scallop Omega -Crystallin Gene. EVIDENCE FOR CONVERGENT EVOLUTION OF PROMOTER SEQUENCES J. Biol. Chem., January 4, 2002; 277(1): 656 - 664. [Abstract] [Full Text]

				W. Ambroziak, G. Izaguirre, and R. Pietruszko Metabolism of Retinaldehyde and Other Aldehydes in Soluble Extracts of Human Liver and Kidney J. Biol. Chem., November 19, 1999; 274(47): 33366 - 33373. [Abstract] [Full Text] [PDF]

				K. Yamauchi, J.-i. Nakajima, H. Hayashi, R. Horiuchi, and J. R. Tata Xenopus Cytosolic Thyroid Hormone-binding Protein (xCTBP) Is Aldehyde Dehydrogenase Catalyzing the Formation of Retinoic Acid J. Biol. Chem., March 26, 1999; 274(13): 8460 - 8469. [Abstract] [Full Text] [PDF]

				J. Jester, T Moller-Pedersen, J Huang, C. Sax, W. Kays, H. Cavangh, W. Petroll, and J Piatigorsky The cellular basis of corneal transparency: evidence for 'corneal crystallins' J. Cell Sci., January 3, 1999; 112(5): 613 - 622. [Abstract] [PDF]

				R. Sharon-Friling, J. Richardson, S. Sperbeck, D. Lee, M. Rauchman, R. Maas, A. Swaroop, and G. Wistow Lens-Specific Gene Recruitment of zeta -Crystallin through Pax6, Nrl-Maf, and Brain Suppressor Sites Mol. Cell. Biol., April 1, 1998; 18(4): 2067 - 2076. [Abstract] [Full Text]

				J. Piatigorsky, Z. Kozmik, J. Horwitz, L. Ding, E. Carosa, W. G. Robison Jr., P. J. Steinbach, and E. R. Tamm Omega -Crystallin of the Scallop Lens. A DIMERIC ALDEHYDE DEHYDROGENASE CLASS 1/2 ENZYME-CRYSTALLIN J. Biol. Chem., December 22, 2000; 275(52): 41064 - 41073. [Abstract] [Full Text] [PDF]

				M. Lin and J. L. Napoli cDNA Cloning and Expression of a Human Aldehyde Dehydrogenase (ALDH) Active with 9-cis-Retinal and Identification of a Rat Ortholog, ALDH12 J. Biol. Chem., December 15, 2000; 275(51): 40106 - 40112. [Abstract] [Full Text] [PDF]