HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Varner, J. A. Search for Related Content PubMed PubMed Citation Articles by Varner, J. A. Social Bookmarking                      What's this?

Volume 271, Number 27, Issue of July 5, 1996 pp. 16119-16125
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

---

Isolation of a Sponge-derived Extracellular Matrix Adhesion Protein

(Received for publication, January 29, 1996, and in revised form, April 9, 1996)

From the Department of Medicine 0063, University of California, San Diego, La Jolla, California 92093-0063

The development of stable intercellular adhesions in the animal kingdom permitted the evolution of the metazoans, of which the sponges are primitive examples. Intercellular adhesion in these simple animals is mediated by a high affinity interaction between the sponge cell surface and aggregation factor, a 2 × 10⁷-Da proteoglycan that is one of the major components of the sponge extracellular matrix. This report describes a sponge cell surface and extracellular matrix ligand for the sponge proteoglycan, aggregation factor. The 210-kDa protein binds aggregation factor proteoglycan with high affinity (K_d = 7 × 10⁹ M). Importantly, in soluble form, it also inhibits aggregation factor-mediated cell adhesion. This glycoprotein is expressed on the sponge cell surface and within the extracellular matrix. This novel sponge extracellular matrix protein may represent a primitive antecedent of the extracellular matrix adhesion proteins of higher organisms.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				X. Fernandez-Busquets and M. M. Burger The Main Protein of the Aggregation Factor Responsible for Species-specific Cell Adhesion in the Marine Sponge Microciona prolifera Is Highly Polymorphic J. Biol. Chem., October 31, 1997; 272(44): 27839 - 27847. [Abstract] [Full Text] [PDF]