| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, February 15, 1996, and in revised form, April 22, 1996)
From the Department of Molecular Biology, Max-Planck-Institut
für Biochemie, Am Klopferspitz 18A, 82152 Martinsried, Federal
Republic of Germany
We have identified a human receptor-like
protein-tyrosine phosphatase (PTP) in the mammary carcinoma cell line
SK-BR-3, which represents the human homolog of murine PTP
Volume 271, Number 28,
Issue of July 12, 1996
pp. 16712-16719
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
with
Members of the Armadillo Family
(Jiang,
Y.-P., Wang, H., D'Eustachio, P., Musacchio, J. M., Schlessinger, J.,
and Sap, J. (1993) Mol. Cell. Biol. 13, 2942-2951) and was
therefore termed hPTP. We show here that hPTP expression is
dependent on cell density and find it colocalized with two members of
the arm family of proteins, 
-catenin and
-catenin/plakoglobin, at adherens junctions. Using both in
vitro and in vivo binding assays, we demonstrate
specific complex formation between endogenous hPTP and - and
-catenin/plakoglobin. In addition, we present evidence that suggests
that -catenin may represent a substrate for the catalytic
activity of hPTP. The identification of specific binding partners
for this receptor-like PTP provides insight into the mechanisms of its
biological action and suggests a role for hPTP in the regulation of
processes involving cell contact and adhesion such as growth control,
tumor invasion, and metastasis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Mertins, H. C. Eberl, J. Renkawitz, J. V. Olsen, M. L. Tremblay, M. Mann, A. Ullrich, and H. Daub Investigation of Protein-tyrosine Phosphatase 1B Function by Quantitative Proteomics Mol. Cell. Proteomics, September 1, 2008; 7(9): 1763 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Flavell, K. R. N. Baumforth, V. H. J. Wood, G. L. Davies, W. Wei, G. M. Reynolds, S. Morgan, A. Boyce, G. L. Kelly, L. S. Young, et al. Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells Blood, January 1, 2008; 111(1): 292 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Aricescu, C. Siebold, K. Choudhuri, V. T. Chang, W. Lu, S. J. Davis, P. A. van der Merwe, and E. Y. Jones Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism Science, August 31, 2007; 317(5842): 1217 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ezaki, R.-J. Guo, H. Li, A. B. Reynolds, and J. P. Lynch The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G54 - G65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Siu, C. Fladd, and D. Rotin N-Cadherin Is an In Vivo Substrate for Protein Tyrosine Phosphatase Sigma (PTP{sigma}) and Participates in PTP{sigma}-Mediated Inhibition of Axon Growth Mol. Cell. Biol., January 1, 2007; 27(1): 208 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sallee, E. S. Wittchen, and K. Burridge Regulation of Cell Adhesion by Protein-tyrosine Phosphatases: II. CELL-CELL ADHESION J. Biol. Chem., June 16, 2006; 281(24): 16189 - 16192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-X. Yan, W. Yang, R. Zhang, L. Chen, L. Tang, B. Zhai, S.-Q. Liu, H.-F. Cao, X.-B. Man, H.-P. Wu, et al. Protein-tyrosine Phosphatase PCP-2 Inhibits beta-Catenin Signaling and Increases E-cadherin-dependent Cell Adhesion J. Biol. Chem., June 2, 2006; 281(22): 15423 - 15433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Eswaran, J. E. Debreczeni, E. Longman, A. J. Barr, and S. Knapp The crystal structure of human receptor protein tyrosine phosphatase {kappa} phosphatase domain 1 Protein Sci., June 1, 2006; 15(6): 1500 - 1505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Anders, P. Mertins, S. Lammich, M. Murgia, D. Hartmann, P. Saftig, C. Haass, and A. Ullrich Furin-, ADAM 10-, and {gamma}-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of {beta}-Catenin's Transcriptional Activity Mol. Cell. Biol., May 15, 2006; 26(10): 3917 - 3934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, L.-J. Tan, V. Grachtchouk, J. J. Voorhees, and G. J. Fisher Receptor-type Protein-tyrosine Phosphatase-{kappa} Regulates Epidermal Growth Factor Receptor Function J. Biol. Chem., December 30, 2005; 280(52): 42694 - 42700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Vogelmann, M.-D. Nguyen-tat, K. Giehl, G. Adler, D. Wedlich, and A. Menke TGF{beta}-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN J. Cell Sci., October 15, 2005; 118(20): 4901 - 4912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Schnekenburger, J Mayerle, B Kruger, I Buchwalow, F U Weiss, E Albrecht, V E Samoilova, W Domschke, and M M Lerch Protein tyrosine phosphatase {kappa} and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the exocrine pancreas Gut, October 1, 2005; 54(10): 1445 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Wang, F. Y. Wu, I. Shin, S. Qu, and C. L. Arteaga Transforming Growth Factor {beta} (TGF-{beta})-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-{beta} Function Mol. Cell. Biol., June 1, 2005; 25(11): 4703 - 4715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W Stoker Protein tyrosine phosphatases and signalling J. Endocrinol., April 1, 2005; 185(1): 19 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. F. Sui, T. D. Kiser, S. W. Hyun, D. J. Angelini, R. L. Del Vecchio, B. A. Young, J. D. Hasday, L. H. Romer, A. Passaniti, N. K. Tonks, et al. Receptor Protein Tyrosine Phosphatase {micro} Regulates the Paracellular Pathway in Human Lung Microvascular Endothelia Am. J. Pathol., April 1, 2005; 166(4): 1247 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Lambeng, Y. Wallez, C. Rampon, F. Cand, G. Christe, D. Gulino-Debrac, I. Vilgrain, and P. Huber Vascular Endothelial-Cadherin Tyrosine Phosphorylation in Angiogenic and Quiescent Adult Tissues Circ. Res., February 18, 2005; 96(3): 384 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bazzoni and E. Dejana Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis Physiol Rev, July 1, 2004; 84(3): 869 - 901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Mariner, M. A. Davis, and A. B. Reynolds EGFR signaling to p120-catenin through phosphorylation at Y228 J. Cell Sci., March 15, 2004; 117(8): 1339 - 1350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kellie, G. Craggs, I. N. Bird, and G. E. Jones The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation J. Cell Sci., February 1, 2004; 117(4): 609 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ito, H. Okazawa, K. Maruyama, K. Tomizawa, S.-i. Motegi, H. Ohnishi, H. Kuwano, A. Kosugi, and T. Matozaki Interaction of SAP-1, a Transmembrane-type Protein-tyrosine Phosphatase, with the Tyrosine Kinase Lck: ROLES IN REGULATION OF T CELL FUNCTION J. Biol. Chem., September 12, 2003; 278(37): 34854 - 34863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Young, X. Sui, T. D. Kiser, S. W. Hyun, P. Wang, S. Sakarya, D. J. Angelini, K. L. Schaphorst, J. D. Hasday, A. S. Cross, et al. Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L63 - L75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Novellino, N. Renkvist, F. Rini, A. Mazzocchi, L. Rivoltini, A. Greco, P. Deho, P. Squarcina, P. F. Robbins, G. Parmiani, et al. Identification of a Mutated Receptor-Like Protein Tyrosine Phosphatase {kappa} as a Novel, Class II HLA-Restricted Melanoma Antigen J. Immunol., June 15, 2003; 170(12): 6363 - 6370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Lampugnani, A. Zanetti, M. Corada, T. Takahashi, G. Balconi, F. Breviario, F. Orsenigo, A. Cattelino, R. Kemler, T. O. Daniel, et al. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, {beta}-catenin, and the phosphatase DEP-1/CD148 J. Cell Biol., May 26, 2003; 161(4): 793 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-Y. Lui, D. D. Mruk, W. M. Lee, and C. Y. Cheng Adherens Junction Dynamics in the Testis and Spermatogenesis J Androl, January 1, 2003; 24(1): 1 - 14. [Full Text] [PDF]
|
|
|
|
|
|
K. G. Johnson and D. Van Vactor Receptor Protein Tyrosine Phosphatases in Nervous System Development Physiol Rev, January 1, 2003; 83(1): 1 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Xu, C. Arregui, J. Lilien, and J. Balsamo PTP1B Modulates the Association of beta -Catenin with N-cadherin through Binding to an Adjacent and Partially Overlapping Target Site J. Biol. Chem., December 13, 2002; 277(51): 49989 - 49997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Taddei, P. Chiarugi, P. Cirri, F. Buricchi, T. Fiaschi, E. Giannoni, D. Talini, G. Cozzi, L. Formigli, G. Raugei, et al. {beta}-Catenin Interacts with Low-Molecular-Weight Protein Tyrosine Phosphatase Leading to Cadherin-mediated Cell-Cell Adhesion Increase Cancer Res., November 15, 2002; 62(22): 6489 - 6499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zanetti, M. G. Lampugnani, G. Balconi, F. Breviario, M. Corada, L. Lanfrancone, and E. Dejana Vascular Endothelial Growth Factor Induces Shc Association With Vascular Endothelial Cadherin: A Potential Feedback Mechanism to Control Vascular Endothelial Growth Factor Receptor-2 Signaling Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 617 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gebauer, H. von Melchner, and T. Beckers Genomewide Trapping of Genes that Encode Secreted and Transmembrane Proteins Repressed by Oncogenic Signaling Genome Res., November 1, 2001; 11(11): 1871 - 1877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Carothers, K. A. Melstrom Jr., J. D. Mueller, M. J. Weyant, and M. M. Bertagnolli Progressive Changes in Adherens Junction Structure during Intestinal Adenoma Formation in Apc Mutant Mice J. Biol. Chem., October 12, 2001; 276(42): 39094 - 39102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barghorn, E. J. M. Speel, B. Farspour, P. Saremaslani, S. Schmid, A. Perren, J. Roth, P. U. Heitz, and P. Komminoth Putative Tumor Suppressor Loci at 6q22 and 6q23-q24 Are Involved in the Malignant Progression of Sporadic Endocrine Pancreatic Tumors Am. J. Pathol., June 1, 2001; 158(6): 1903 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Trapasso, R. Iuliano, A. Boccia, A. Stella, R. Visconti, P. Bruni, G. Baldassarre, M. Santoro, G. Viglietto, and A. Fusco Rat Protein Tyrosine Phosphatase eta Suppresses the Neoplastic Phenotype of Retrovirally Transformed Thyroid Cells through the Stabilization of p27Kip1 Mol. Cell. Biol., December 15, 2000; 20(24): 9236 - 9246. [Abstract] [Full Text]
|
|
|
|
|
|
G. C. M. Zondag, A. B. Reynolds, and W. H. Moolenaar Receptor Protein-tyrosine Phosphatase RPTP{micro} Binds to and Dephosphorylates the Catenin p120ctn J. Biol. Chem., April 6, 2000; 275(15): 11264 - 11269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Petrone and J Sap Emerging issues in receptor protein tyrosine phosphatase function: lifting fog or simply shifting? J. Cell Sci., January 7, 2000; 113(13): 2345 - 2354. [Abstract] [PDF]
|
|
|
|
|
|
P. Andriopoulou, P. Navarro, A. Zanetti, M. G. Lampugnani, and E. Dejana Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2286 - 2297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Taniguchi, R. London, K. Schinkmann, S. Jiang, and H. Avraham The Receptor Protein Tyrosine Phosphatase, PTP-RO, Is Upregulated During Megakaryocyte Differentiation and Is Associated With the c-Kit Receptor Blood, July 15, 1999; 94(2): 539 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Goldblum, B. A. Young, P. Wang, and J. E. Murphy-Ullrich Thrombospondin-1 Induces Tyrosine Phosphorylation of Adherens Junction Proteins and Regulates an Endothelial Paracellular Pathway Mol. Biol. Cell, May 1, 1999; 10(5): 1537 - 1551. [Abstract] [Full Text]
|
|
|
|
|
|
T. Muller, A. Choidas, E. Reichmann, and A. Ullrich Phosphorylation and Free Pool of beta -Catenin Are Regulated by Tyrosine Kinases and Tyrosine Phosphatases during Epithelial Cell Migration J. Biol. Chem., April 9, 1999; 274(15): 10173 - 10183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Pötter, C. Bergwitz, and G. Brabant The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues Endocr. Rev., April 1, 1999; 20(2): 207 - 239. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Burden-Gulley and S. M. Brady-Kalnay PTPµ Regulates N-Cadherin-dependent Neurite Outgrowth J. Cell Biol., March 22, 1999; 144(6): 1323 - 1336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bauer, H. Lickert, R. Kemler, and J. Stappert Modification of the E-cadherin-Catenin Complex in Mitotic Madin-Darby Canine Kidney Epithelial Cells J. Biol. Chem., October 23, 1998; 273(43): 28314 - 28321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balsamo, C. Arregui, T. Leung, and J. Lilien The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin-Actin Linkage J. Cell Biol., October 19, 1998; 143(2): 523 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Edwards, F. H. Wilford, X. Liu, L. Hennighausen, J. Djiane, and C. H. Streuli Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases J. Biol. Chem., April 17, 1998; 273(16): 9495 - 9500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Brady-Kalnay, T. Mourton, J. P. Nixon, G. E. Pietz, M. Kinch, H. Chen, R. Brackenbury, D. L. Rimm, R. L. Del Vecchio, and N. K. Tonks Dynamic Interaction of PTPµ with Multiple Cadherins In Vivo J. Cell Biol., April 6, 1998; 141(1): 287 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ozawa and R. Kemler Altered Cell Adhesion Activity by Pervanadate Due to the Dissociation of alpha -Catenin from the E-Cadherin·Catenin Complex J. Biol. Chem., March 13, 1998; 273(11): 6166 - 6170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Esser, M. Lampugnani, M Corada, E Dejana, and W Risau Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells J. Cell Sci., January 7, 1998; 111(13): 1853 - 1865. [Abstract] [PDF]
|
|
|
|
|
|
K. M. V. Hoffmann, N. K. Tonks, and D. Barford The Crystal Structure of Domain 1 of Receptor Protein-tyrosine Phosphatase µ J. Biol. Chem., October 31, 1997; 272(44): 27505 - 27508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Spencer, D. Dowbenko, J. Cheng, W. Li, J. Brush, S. Utzig, V. Simanis, and L. A. Lasky PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow-associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase J. Cell Biol., August 25, 1997; 138(4): 845 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Aicher, M. M. Lerch, T. Muller, J. Schilling, and A. Ullrich Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPsigma by Inducible Proteolytic Processing J. Cell Biol., August 11, 1997; 138(3): 681 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cheng, K. Wu, M. Armanini, N. O'Rourke, D. Dowbenko, and L. A. Lasky A Novel Protein-Tyrosine Phosphatase Related to the Homotypically Adhering kappa andµReceptors J. Biol. Chem., March 14, 1997; 272(11): 7264 - 7277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lampugnani, M Corada, P Andriopoulou, S Esser, W Risau, and E Dejana Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells J. Cell Sci., January 9, 1997; 110(17): 2065 - 2077. [Abstract] [PDF]
|
|
|
|
|
|
H. Keilhack, U. Hellman, J. van Hengel, F. van Roy, J. Godovac-Zimmermann, and F.-D. Bohmer The Protein-tyrosine Phosphatase SHP-1 Binds to and Dephosphorylates p120 Catenin J. Biol. Chem., August 18, 2000; 275(34): 26376 - 26384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Noguchi, M. Tsuda, H. Takeda, T. Takada, K. Inagaki, T. Yamao, K. Fukunaga, T. Matozaki, and M. Kasuga Inhibition of Cell Growth and Spreading by Stomach Cancer-associated Protein-tyrosine Phosphatase-1 (SAP-1) through Dephosphorylation of p130cas J. Biol. Chem., April 27, 2001; 276(18): 15216 - 15224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Mariner, P. Anastasiadis, H. Keilhack, F.-D. Bohmer, J. Wang, and A. B. Reynolds Identification of Src Phosphorylation Sites in the Catenin p120ctn J. Biol. Chem., July 20, 2001; 276(30): 28006 - 28013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Gaudry, H. L. Palka, R. L. Dusek, A. C. Huen, M. J. Khandekar, L. G. Hudson, and K. J. Green Tyrosine-phosphorylated Plakoglobin Is Associated with Desmogleins but Not Desmoplakin after Epidermal Growth Factor Receptor Activation J. Biol. Chem., June 29, 2001; 276(27): 24871 - 24880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Xu, R. Zhao, Y. Peng, A. Guerrah, and Z. J. Zhao Association of Tyrosine Phosphatase SHP-2 with F-actin at Low Cell Densities J. Biol. Chem., July 27, 2001; 276(31): 29479 - 29484. [Abstract] [Full Text] [PDF]
|
|
|
