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Volume 271, Number 3, Issue of January 19, 1996 pp. 1441-1447
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
Identification of Chitinase as the Immunodominant Filarial Antigen Recognized by Sera of Vaccinated Rodents

(Received for publication, September 5, 1995; and in revised form, November 8, 1995)

Ralf Adam ,  Brigitte Kaltmann ,  Werner Rudin ,  Thomas Friedrich ,  Thomas Marti ,  Richard Lucius

Acanthocheilonema viteae is a parasitic nematode of rodents. We identified the chitinase of A. viteae infective stage larvae (L3) as the main target of the humoral immune response of jirds, which were protected against challenge infection after vaccination with irradiation attenuated L3. The cDNA of the L3 chitinase has been sequenced, and the deduced amino acid sequence shows significant homologies to chitinases of Brugia malayi microfilariae, insects, yeast, bacteria, and Streptomyces sp. The protein has been characterized by monoclonal antibodies and substrate activity gels. The chitinase of L3 may contribute to degrading the nematode cuticle during molting and thus represents a target of protective immune responses in a phase where the parasite is highly vulnerable. In addition, it has been shown that a similar enzyme exists in uterine microfilariae, which probably has a role in casting the egg shell.



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