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Volume 271, Number 30, Issue of July 26, 1996 pp. 17625-17628
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

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COMMUNICATION:
Saturable Ethanol Binding in Rat Liver Microsomes

(Received for publication, May 8, 1996, and in revised form, June 4, 1996)

From the Department of Pathology, Anatomy, and Cell Biology, Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107

The binding of ethanol to rat liver microsomes is shown to be saturable at clinically relevant ethanol concentrations, whereas this effect is not observed in extracted microsomal phospholipids. Brief exposure of the microsomes to heat abolishes saturable ethanol binding. Equilibrium binding data analysis, although only approximate in this context, suggests the presence of at least two groups of specific sites: high capacity sites with affinities near the pharmacological range and low capacity sites at lesser levels. The results indicate that the specificity of ethanol for tissue is considerably greater than previously recognized.

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