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(Received for publication, December 29, 1995, and in revised form, May 2, 1996)
From the Hagedorn Research Institute, Niels Steensensvej 6, DK-2820 Gentofte, Denmark
Development of a high capacity multiplex reverse
transcriptase-polymerase chain reaction protocol has allowed us to
screen lineage related rat islet tumors classified as
Volume 271, Number 31,
Issue of August 2, 1996
pp. 18749-18758
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
-Cell-specific Homeodomain Transcription Factor
-, 
-, and
-like as judged by their hormone profile for differential expression
of more than 50 selected genes. We find that in addition to insulin the
insulinoma express the normal -cell markers Pdx-1, IAPP, and Glut-2,
and that these markers are absent from the glucagonoma: a reflection of
the normal -cell. Furthermore, this study suggests that the GLP-1,
glucagon, GIP, IGF-1, and insulin receptors as well as E-cadherin,
R-cadherin, Id-1, and Id-2 are differentially expressed within the
islet of Langerhans. Importantly, insulinoma-specific expression of the
recently cloned homeodomain protein Nkx 6.1 predicted -cell-specific
expression in the normal islet. Immunohistochemistry using antibodies
raised against recombinant Nkx 6.1 did indeed localize Nkx 6.1 expression exclusively to the nuclei of normal islet -cells. Apart
from pancreatic islets only the antral part of the stomach contained
Nkx 6.1 mRNA. We conclude that multiplex reverse
transcriptase-polymerase chain reaction-based mRNA profiling is a
powerful tool to identify differentially expressed genes within
phenotypically related cells and propose that Nkx 6.1 is involved in
specifying the unique characteristics of the -cell.
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