|
|
|
|||||||
|
|||||||||
(Received for publication, March 18, 1996, and in revised form, June 3, 1996)
From the The NF-
Volume 271, Number 34,
Issue of August 23, 1996
pp. 20828-20835
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
B-mediated Transcription in
Human Monocytic Cells and Endothelial Cells
,
,
,
and
Departments of Immunology and Vascular
Biology, Scripps Research Institute, La Jolla, California 92037, the
'' 
Department of Biology, Tanabe Research Laboratories, San
Diego, California 92121, and 
INSERM U294 and Service
d'Hematologie et d'Immunologie Biologiques, Chu Xavier Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France
B/Rel family of transcription factors
regulates the inducible expression of many genes in activated human
monocytes and endothelial cells. In this study, we examined the
molecular mechanism by which agents that elevate intracellular cAMP
inhibit the expression of the tumor necrosis factor 
(TNF),
tissue factor, endothelial leukocyte adhesion molecule-1, and vascular
cell adhesion molecule-1 genes. Both forskolin and dibutyryl cAMP,
which elevate intracellular cAMP by independent mechanisms, inhibited
TNF and tissue factor expression at the level of transcription.
Induction of NF-B-dependent gene expression in
transiently transfected human monocytic THP-1 cells and human umbilical
vein endothelial cells was inhibited by elevated cAMP and by
overexpression of the catalytic subunit of protein kinase A (PKA).
Elevated cAMP did not prevent nuclear translocation of p50/p65 and
c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or
significantly modify TNF-induced phosphorylation of p65. Functional
studies demonstrated that transcriptional activation of a plasmid
containing multimerized B sites by p65 was inhibited by agents that
elevate cAMP and by overexpression of the catalytic subunit of PKA.
This study indicates that activation of PKA reduces the induction of a
distinct set of genes in monocytes and endothelial cells by inhibiting
NF-B-mediated transcription.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. A. Wall, J. R. Zavzavadjian, M. S. Chang, B. Randhawa, X. Zhu, R. C. Hsueh, J. Liu, A. Driver, X. R. Bao, P. C. Sternweis, et al. Suppression of LPS-Induced TNF-{alpha} Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105 Sci. Signal., June 16, 2009; 2(75): ra28 - ra28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gobejishvili, S. Barve, S. Joshi-Barve, and C. McClain Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease Am J Physiol Gastrointest Liver Physiol, October 1, 2008; 295(4): G718 - G724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-P. Lei, H.-W. Chen, L.-Y. Sheen, and C.-K. Lii Diallyl Disulfide and Diallyl Trisulfide Suppress Oxidized LDL-Induced Vascular Cell Adhesion Molecule and E-Selectin Expression through Protein Kinase A- and B-Dependent Signaling Pathways J. Nutr., June 1, 2008; 138(6): 996 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Seldon, G. Silva, N. Pejanovic, R. Larsen, I. P. Gregoire, J. Filipe, J. Anrather, and M. P. Soares Heme Oxygenase-1 Inhibits the Expression of Adhesion Molecules Associated with Endothelial Cell Activation via Inhibition of NF-{kappa}B RelA Phosphorylation at Serine 276 J. Immunol., December 1, 2007; 179(11): 7840 - 7851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tessier, C. Green, D. Padgett, W. Zhao, L. Schwartz, M. Hughes, and E. Hewlett Contributions of Histamine, Prostanoids, and Neurokinins to Edema Elicited by Edema Toxin from Bacillus anthracis Infect. Immun., April 1, 2007; 75(4): 1895 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Janciauskiene, I. M. Nita, and T. Stevens {alpha}1-Antitrypsin, Old Dog, New Tricks: {alpha}1-ANTITRYPSIN EXERTS IN VITRO ANTI-INFLAMMATORY ACTIVITY IN HUMAN MONOCYTES BY ELEVATING cAMP J. Biol. Chem., March 23, 2007; 282(12): 8573 - 8582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhou, K. Hashimoto, K. Goleniewska, J. F. O'Neal, S. Ji, T. S. Blackwell, G. A. FitzGerald, K. M. Egan, M. W. Geraci, and R. S. Peebles Jr. Prostaglandin I2 Analogs Inhibit Proinflammatory Cytokine Production and T Cell Stimulatory Function of Dendritic Cells J. Immunol., January 15, 2007; 178(2): 702 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Hoare, E. J. Birks, C. Bowles, N. Marczin, and M. H. Yacoub In vitro endothelial cell activation and inflammatory responses in end-stage heart failure J Appl Physiol, November 1, 2006; 101(5): 1466 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gobejishvili, S. Barve, S. Joshi-Barve, S. Uriarte, Z. Song, and C. McClain Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-{kappa}B activity and TNF expression: relevance to alcoholic liver disease Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G681 - G688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Levy, M. Coughlin, B. N. Cronstein, R. M. Roy, A. Desai, and M. R. Wessels The Adenosine System Selectively Inhibits TLR-Mediated TNF-{alpha} Production in the Human Newborn J. Immunol., August 1, 2006; 177(3): 1956 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Park, J. H. Lee, C. D. Kim, W. S. Lee, W. S. Park, J. Han, Y.-G. Kwak, K. Y. Kim, and K. W. Hong Cilostazol Suppresses Superoxide Production and Expression of Adhesion Molecules in Human Endothelial Cells via Mediation of cAMP-Dependent Protein Kinase-Mediated Maxi-K Channel Activation J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1238 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Loza, S. Foster, S. P. Peters, and R. B. Penn Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells Blood, March 1, 2006; 107(5): 2052 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Allen, M. M. Randolph, and J. M. Fleckenstein Importance of Heat-Labile Enterotoxin in Colonization of the Adult Mouse Small Intestine by Human Enterotoxigenic Escherichia coli Strains Infect. Immun., February 1, 2006; 74(2): 869 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kaufmann, B. Musset, S. H. Limberg, V. Renigunta, R. Sus, A. H. Dalpke, K. M. Heeg, B. Robaye, and P. J. Hanley "Host Tissue Damage" Signal ATP Promotes Non-directional Migration and Negatively Regulates Toll-like Receptor Signaling in Human Monocytes J. Biol. Chem., September 16, 2005; 280(37): 32459 - 32467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nie, A. J. Knox, and L. Pang {beta}2-Adrenoceptor Agonists, Like Glucocorticoids, Repress Eotaxin Gene Transcription by Selective Inhibition of Histone H4 Acetylation J. Immunol., July 1, 2005; 175(1): 478 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Sohn, C. B. Deming, D. C. Johns, H. C. Champion, C. Bian, K. Gardner, and J. J. Rade Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B Blood, May 15, 2005; 105(10): 3910 - 3917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Lee, G. T. Oh, S. Y. Park, J.-H. Choi, J.-G. Park, C. D. Kim, W. S. Lee, B. Y. Rhim, Y. W. Shin, and K. W. Hong Cilostazol Reduces Atherosclerosis by Inhibition of Superoxide and Tumor Necrosis Factor-{alpha} Formation in Low-Density Lipoprotein Receptor-Null Mice Fed High Cholesterol J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 502 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Cao, F. Kambe, and H. Seo Requirement of Thyrotropin-Dependent Complex Formation of Protein Kinase A Catalytic Subunit with Inhibitor of {kappa}B Proteins for Activation of p65 Nuclear Factor-{kappa}B by Tumor Necrosis Factor-{alpha} Endocrinology, April 1, 2005; 146(4): 1999 - 2005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Park, J. H. Lee, Y. K. Kim, C. D. Kim, B. Y. Rhim, W. S. Lee, and K. W. Hong Cilostazol Prevents Remnant Lipoprotein Particle-Induced Monocyte Adhesion to Endothelial Cells by Suppression of Adhesion Molecules and Monocyte Chemoattractant Protein-1 Expression via Lectin-Like Receptor for Oxidized Low-Density Lipoprotein Receptor Activation J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 1241 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Smith, L. B. Cieslinski, R. Newton, L. E. Donnelly, P. S. Fenwick, A. G. Nicholson, P. J. Barnes, M. S. Barnette, and M. A. Giembycz Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes Mol. Pharmacol., December 1, 2004; 66(6): 1679 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Loop, T. Bross, M. Humar, A. Hoetzel, R. Schmidt, H. L. Pahl, K. K. Geiger, and B. H. J. Pannen Dobutamine Inhibits Phorbol-Myristate-Acetate-Induced Activation of Nuclear Factor-{kappa}B in Human T Lymphocytes In Vitro Anesth. Analg., November 1, 2004; 99(5): 1508 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rahman, K. N. Anwar, Mohd. Minhajuddin, K. M. Bijli, K. Javaid, A. L. True, and A. B. Malik cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-{kappa}B activation and ICAM-1 expression in endothelial cells Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L1017 - L1024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Largo, I Diez-Ortego, O Sanchez-Pernaute, M J Lopez-Armada, M A Alvarez-Soria, J Egido, and G Herrero-Beaumont EP2/EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1{beta} in synovial fibroblasts Ann Rheum Dis, October 1, 2004; 63(10): 1197 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-L. Chi, S. Hayasaka, X.-Y. Zhang, Y. Hayasaka, and H.-S. Cui Effects of Rolipram, a Selective Inhibitor of Type 4 Phosphodiesterase, on Lipopolysaccharide-Induced Uveitis in Rats Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2497 - 2502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cazzola and R. Dahl Inhaled Combination Therapy With Long-Acting {beta}2-Agonists and Corticosteroids in Stable COPD Chest, July 1, 2004; 126(1): 220 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ma, X. Cui, S. Wang, J. Zhang, E. V. Nishanian, W. Wang, R. A. Wesley, and R. L. Danner Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation J. Leukoc. Biol., July 1, 2004; 76(1): 278 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-Y. Xiao, K.-i. Yuhki, A. Hara, T. Fujino, S. Kuriyama, T. Yamada, K. Takayama, O. Takahata, H. Karibe, T. Taniguchi, et al. Prostaglandin E2 Protects the Heart From Ischemia-Reperfusion Injury via Its Receptor Subtype EP4 Circulation, May 25, 2004; 109(20): 2462 - 2468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-M. Chen, Y.-Y. Ng, S.-L. Lin, W.-C. Chiang, H. Y. Lan, and T.-J. Tsai Pentoxifylline suppresses renal tumour necrosis factor-{alpha} and ameliorates experimental crescentic glomerulonephritis in rats Nephrol. Dial. Transplant., May 1, 2004; 19(5): 1106 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Abeyama, K.-i. Kawahara, S. Iino, T. Hamada, S.-i. Arimura, K. Matsushita, T. Nakajima, and I. Maruyama Antibiotic cyclic AMP signaling by "primed" leukocytes confers anti-inflammatory cytoprotection J. Leukoc. Biol., November 1, 2003; 74(5): 908 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Y. Yeung, D. K. O. Chan, N. K. Mak, G. F. Wagner, and C. K. C. Wong Identification of Signal Transduction Pathways that Modulate Dibutyryl Cyclic Adenosine Monophosphate Activation of Stanniocalcin Gene Expression in Neuroblastoma Cells Endocrinology, October 1, 2003; 144(10): 4446 - 4452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Aizawa, H. Wei, J. M. Miano, J.-i. Abe, B. C. Berk, and C. Yan Role of Phosphodiesterase 3 in NO/cGMP-Mediated Antiinflammatory Effects in Vascular Smooth Muscle Cells Circ. Res., September 5, 2003; 93(5): 406 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, S. Wang, R. A. Wesley, and R. L. Danner Adjacent Sequence Controls the Response Polarity of Nitric Oxide-sensitive Sp Factor Binding Sites J. Biol. Chem., August 1, 2003; 278(31): 29192 - 29200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mizutani, K. Okajima, M. Uchiba, H. Isobe, N. Harada, S. Mizutani, and T. Noguchi Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production Blood, April 15, 2003; 101(8): 3029 - 3036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schiekofer, M. Andrassy, J. Chen, G. Rudofsky, J. Schneider, T. Wendt, N. Stefan, P. Humpert, A. Fritsche, M. Stumvoll, et al. Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor {kappa}B in PBMCs Diabetes, March 1, 2003; 52(3): 621 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]
|
|
|
|
|
|
K. Bshesh, B. Zhao, D. Spight, I. Biaggioni, I. Feokistov, A. Denenberg, H. R. Wong, and T. P. Shanley The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells J. Leukoc. Biol., November 1, 2002; 72(5): 1027 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Arcaroli, K.-Y. Yang, H.-K. Yum, J. Kupfner, T. M. Pitts, J. S. Park, D. Strassheim, and E. Abraham Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia J. Leukoc. Biol., September 1, 2002; 72(3): 571 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Luft, M. Jefford, P. Luetjens, T. Toy, H. Hochrein, K.-A. Masterman, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E2 regulates the migratory capacity of specific DC subsets Blood, July 30, 2002; 100(4): 1362 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Jain, K. Kannan, G. Lim, R. McVie, and J. A. Bocchini Jr. Hyperketonemia Increases Tumor Necrosis Factor-{alpha} Secretion in Cultured U937 Monocytes and Type 1 Diabetic Patients and Is Apparently Mediated by Oxidative Stress and cAMP Deficiency Diabetes, July 1, 2002; 51(7): 2287 - 2293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Loewe, W. Holnthoner, M. Groger, M. Pillinger, F. Gruber, D. Mechtcheriakova, E. Hofer, K. Wolff, and P. Petzelbauer Dimethylfumarate Inhibits TNF-Induced Nuclear Entry of NF-{kappa}B/p65 in Human Endothelial Cells J. Immunol., May 1, 2002; 168(9): 4781 - 4787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Colombo, A. W. Ashton, S. Celaj, A. Talreja, J. E. Banchs, N. B. Dubois, M. Marinaccio, S. Malla, J. Lachmann, J. A. Ware, et al. Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endothelium J Appl Physiol, March 1, 2002; 92(3): 1331 - 1338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Isobe, K. Okajima, M. Uchiba, N. Harada, and H. Okabe Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rats Blood, March 1, 2002; 99(5): 1638 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. NAKAMURA, E. J. JOHNS, A. IMAIZUMI, Y. YANAGAWA, and T. KOHSAKA Activation of {beta}2-Adrenoceptor Prevents Shiga Toxin 2-Induced TNF-{alpha} Gene Transcription J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2288 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Khoa, M. C. Montesinos, A. B. Reiss, D. Delano, N. Awadallah, and B. N. Cronstein Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells J. Immunol., October 1, 2001; 167(7): 4026 - 4032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Friedland, D. Constantin, T. C. Shaw, and E. Stylianou Regulation of interleukin-8 gene expression after phagocytosis of zymosan by human monocytic cells J. Leukoc. Biol., September 1, 2001; 70(3): 447 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shenkar, H.-K. Yum, J. Arcaroli, J. Kupfner, and E. Abraham Interactions between CBP, NF-{kappa}B, and CREB in the lungs after hemorrhage and endotoxemia Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L418 - L426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. McPherson, K. G. Barringhaus, G. G. Bishop, J. M. Sanders, J. M. Rieger, S. E. Hesselbacher, L. W. Gimple, E. R. Powers, T. Macdonald, G. Sullivan, et al. Adenosine A2A Receptor Stimulation Reduces Inflammation and Neointimal Growth in a Murine Carotid Ligation Model Arterioscler. Thromb. Vasc. Biol., May 1, 2001; 21(5): 791 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Goebeler, R. Gillitzer, K. Kilian, K. Utzel, E.-B. Brocker, U. R. Rapp, and S. Ludwig Multiple signaling pathways regulate NF-{kappa}B-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells Blood, January 1, 2001; 97(1): 46 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Speir, Z.-X. Yu, K. Takeda, V. J. Ferrans, and R. O. Cannon III Antioxidant Effect of Estrogen on Cytomegalovirus-Induced Gene Expression in Coronary Artery Smooth Muscle Cells Circulation, December 12, 2000; 102(24): 2990 - 2996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nakamura, E. J. Johns, A. Imaizumi, Y. Yanagawa, and T. Kohsaka {beta}2-Adrenoceptor agonist suppresses renal tumour necrosis factor and enhances interleukin-6 gene expression induced by endotoxin Nephrol. Dial. Transplant., December 1, 2000; 15(12): 1928 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Ye beta -Adrenergic agonists regulate NF-kappa B activation through multiple mechanisms Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L615 - L617. [Full Text] [PDF]
|
|
|
|
|
|
P. Farmer and J. Pugin beta -Adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the Ikappa B/NF-kappa B pathway Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L675 - L682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Harada, K. Okajima, K. Murakami, S. Usune, C. Sato, K. Ohshima, and T. Katsuragi Adenosine and Selective A2A Receptor Agonists Reduce Ischemia/Reperfusion Injury of Rat Liver Mainly by Inhibiting Leukocyte Activation J. Pharmacol. Exp. Ther., September 1, 2000; 294(3): 1034 - 1042. [Abstract] [Full Text]
|
|
|
|
|
|
A. L. True, A. Rahman, and A. B. Malik Activation of NF-kappa B induced by H2O2 and TNF-alpha and its effects on ICAM-1 expression in endothelial cells Am J Physiol Lung Cell Mol Physiol, August 1, 2000; 279(2): L302 - L311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Komatsu, R. D. Berg, J. M. Russell, Y. Nimura, and D. N. Granger Enteric microflora contribute to constitutive ICAM-1 expression on vascular endothelial cells Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G186 - G191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-K. Kim, Y. Kan, D. Ganea, R. P. Hart, I. Gozes, and G. M. Jonakait Vasoactive Intestinal Peptide and Pituitary Adenylyl Cyclase-Activating Polypeptide Inhibit Tumor Necrosis Factor-alpha Production in Injured Spinal Cord and in Activated Microglia via a cAMP-Dependent Pathway J. Neurosci., May 15, 2000; 20(10): 3622 - 3630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Manna, A. Mukhopadhyay, and B. B. Aggarwal Human Chorionic Gonadotropin Suppresses Activation of Nuclear Transcription Factor-kappa B and Activator Protein-1 Induced by Tumor Necrosis Factor J. Biol. Chem., April 28, 2000; 275(18): 13307 - 13314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Pueyo, W. Gonzalez, A. Nicoletti, F. Savoie, J.-F. Arnal, and J.-B. Michel Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-{kappa}B Activation Induced by Intracellular Oxidative Stress Arterioscler. Thromb. Vasc. Biol., March 1, 2000; 20(3): 645 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hoshi, M. Goto, N. Koyama, K.-i. Nomoto, and H. Tanaka Regulation of Vascular Smooth Muscle Cell Proliferation by Nuclear Factor-kappa B and Its Inhibitor, I-kappa B J. Biol. Chem., January 14, 2000; 275(2): 883 - 889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wang, W. Wang, R. A. Wesley, and R. L. Danner A Sp1 Binding Site of the Tumor Necrosis Factor alpha Promoter Functions as a Nitric Oxide Response Element J. Biol. Chem., November 19, 1999; 274(47): 33190 - 33193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado and D. Ganea Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Interleukin-12 Transcription by Regulating Nuclear Factor kappa B and Ets Activation J. Biol. Chem., November 5, 1999; 274(45): 31930 - 31940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Boyle Jr, T. G. Canty Jr, E. N. Morgan, W. Yun, T. H. Pohlman, and E. D. Verrier Treating myocardial ischemia-reperfusion injury by targeting endothelial cell transcription Ann. Thorac. Surg., November 1, 1999; 68(5): 1949 - 1953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Leitinger, T. R. Tyner, L. Oslund, C. Rizza, G. Subbanagounder, H. Lee, P. T. Shih, N. Mackman, G. Tigyi, M. C. Territo, et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils PNAS, October 12, 1999; 96(21): 12010 - 12015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Jackson, F. Parhami, X.-P. Xi, J. A. Berliner, W. A. Hsueh, R. E. Law, and L. L. Demer Peroxisome Proliferator–Activated Receptor Activators Target Human Endothelial Cells to Inhibit Leukocyte–Endothelial Cell Interaction Arterioscler. Thromb. Vasc. Biol., September 1, 1999; 19(9): 2094 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Silverman, C. R. Waters, G. T. Hayman, J. Wigboldus, M. M. Samet, and P. I. Lelkes Tissue factor activity is increased in human endothelial cells cultured under elevated static pressure Am J Physiol Cell Physiol, August 1, 1999; 277(2): C233 - C242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shenkar and E. Abraham Mechanisms of Lung Neutrophil Activation After Hemorrhage or Endotoxemia: Roles of Reactive Oxygen Intermediates, NF-{kappa}B, and Cyclic AMP Response Element Binding Protein J. Immunol., July 15, 1999; 163(2): 954 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Jeong, S.-G. Ahn, J.-H. Lee, H.-S. Kim, J.-W. Kim, H. Rhim, S.-W. Jeong, and I.-K. Kim 3-Deazaadenosine, a S-Adenosylhomocysteine Hydrolase Inhibitor, Has Dual Effects on NF-kappa B Regulation. INHIBITION OF NF-kappa B TRANSCRIPTIONAL ACTIVITY AND PROMOTION OF Ikappa Balpha DEGRADATION J. Biol. Chem., July 2, 1999; 274(27): 18981 - 18988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Anrather, V. Csizmadia, M. P. Soares, and H. Winkler Regulation of NF-kappa B RelA Phosphorylation and Transcriptional Activity by p21ras and Protein Kinase Czeta in Primary Endothelial Cells J. Biol. Chem., May 7, 1999; 274(19): 13594 - 13603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Engelmann, S. Zieseniss, K. Brand, S. Page, A. Lentschat, A. J. Ulmer, and E. Gerlach Tissue Factor Expression of Human Monocytes Is Suppressed by Lysophosphatidylcholine Arterioscler. Thromb. Vasc. Biol., January 1, 1999; 19(1): 47 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado, E. J. Munoz-Elias, Y. Kan, I. Gozes, M. Fridkin, D. E. Brenneman, R. P. Gomariz, and D. Ganea Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Tumor Necrosis Factor alpha Transcriptional Activation by Regulating Nuclear Factor-kB and cAMP Response Element-binding Protein/c-Jun J. Biol. Chem., November 20, 1998; 273(47): 31427 - 31436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Manna and B. B. Aggarwal {alpha}-Melanocyte-Stimulating Hormone Inhibits the Nuclear Transcription Factor NF-{kappa}B Activation Induced by Various Inflammatory Agents J. Immunol., September 15, 1998; 161(6): 2873 - 2880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Oeth, J. Yao, S.-T. Fan, and N. Mackman Retinoic Acid Selectively Inhibits Lipopolysaccharide Induction of Tissue Factor Gene Expression in Human Monocytes Blood, April 15, 1998; 91(8): 2857 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Krikun, F. Schatz, N. Mackman, S. Guller, and C. J. Lockwood Transcriptional Regulation of the Tissue Factor Gene by Progestins in Human Endometrial Stromal Cells J. Clin. Endocrinol. Metab., March 1, 1998; 83(3): 926 - 930. [Abstract] [Full Text]
|
|
|
|
|
|
M. Ahmad, P. Theofanidis, and R. M. Medford Role of Activating Protein-1 in the Regulation of the Vascular Cell Adhesion Molecule-1 Gene Expression by Tumor Necrosis Factor-alpha J. Biol. Chem., February 20, 1998; 273(8): 4616 - 4621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Bird, K. Schooley, S. K. Dower, H. Hagen, and G. D. Virca Activation of Nuclear Transcription Factor NF-kappa B by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit J. Biol. Chem., December 19, 1997; 272(51): 32606 - 32612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. R. Pendurthi, J. T. Williams, and L. V. M. Rao Inhibition of Tissue Factor Gene Activation in Cultured Endothelial Cells by Curcumin : Suppression of Activation of Transcription Factors Egr-1, AP-1, and NF-{kappa}B Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3406 - 3413. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |