(Received for publication, July 1, 1996)

Nan Wang , Wei Weng ^§ , Jan L. Breslow ^§ and Alan R. Tall

From the  Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032 and the ^§ Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021

Scavenger receptor BI (SR-BI), a putative high density lipoprotein (HDL) receptor, mediates the selective uptake of HDL cholesteryl ester into cells and is highly expressed in adrenal gland (Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., and Krieger, M. (1996) Science 271, 518-520). Apolipoprotein A-I knock-out (apoA-I0) mice have decreased HDL cholesterol, depleted adrenal cholesterol stores and impaired corticosteroid synthesis (Plump, A. S., Erickson, S. K., Weng, W., Partin, J. S., Breslow, J. L., and Williams, D. L. (1996) J. Clin. Invest. 97, 2660-2671). We now show up-regulation of adrenal SR-BI mRNA and protein in apoA-I0 mice, but not in apoA-II0, LDL receptor 0, apoE0, or cholesteryl ester transfer protein transgenic mice. Adrenal SR-BI mRNA and protein are also increased and cholesterol stores decreased in female mice with knock-out of hepatic lipase, an enzyme previously shown to increase selective uptake in cell culture. SR-BI mRNA is increased in stressed wild type mice and in Y1 adrenal cells treated with adrenocorticotropic hormone; the latter effect is inhibited by HDL. These findings provide in vivo evidence showing SR-BI is a functional HDL receptor under feedback control. The action of hepatic lipase on apoA-I-containing lipoproteins may facilitate the SR-BI-mediated uptake of HDL lipid.

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				D. Calvo, D. Gomez-Coronado, M. A. Lasuncion, and M. A. Vega CLA-1 Is an 85-kD Plasma Membrane Glycoprotein That Acts as a High-Affinity Receptor for Both Native (HDL, LDL, and VLDL) and Modified (OxLDL and AcLDL) Lipoproteins Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2341 - 2349. [Abstract] [Full Text]

				F. Benoist, P. Lau, M. McDonnell, H. Doelle, R. Milne, and R. McPherson Cholesteryl Ester Transfer Protein Mediates Selective Uptake of High Density Lipoprotein Cholesteryl Esters by Human Adipose Tissue J. Biol. Chem., September 19, 1997; 272(38): 23572 - 23577. [Abstract] [Full Text] [PDF]

				O. Stein, Y. Dabach, G. Hollander, M. Ben-Naim, G. Halperin, J. L. Breslow, and Y. Stein Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice PNAS, September 2, 1997; 94(18): 9820 - 9824. [Abstract] [Full Text] [PDF]

				Y. Ji, B. Jian, N. Wang, Y. Sun, M. d. l. L. Moya, M. C. Phillips, G. H. Rothblat, J. B. Swaney, and A. R. Tall Scavenger Receptor BI Promotes High Density Lipoprotein-mediated Cellular Cholesterol Efflux J. Biol. Chem., August 22, 1997; 272(34): 20982 - 20985. [Abstract] [Full Text] [PDF]

				J. Liu, R. Voutilainen, P. Heikkila, and A. I. Kahri Ribonucleic Acid Expression of the CLA-1 Gene, a Human Homolog to Mouse High Density Lipoprotein Receptor SR-BI, in Human Adrenal Tumors and Cultured Adrenal Cells J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2522 - 2527. [Abstract] [Full Text] [PDF]

				K. Murao, V. Terpstra, S. R. Green, N. Kondratenko, D. Steinberg, and O. Quehenberger Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes J. Biol. Chem., July 11, 1997; 272(28): 17551 - 17557. [Abstract] [Full Text] [PDF]

				D. S. Ng, O. L. Francone, T. M. Forte, J. Zhang, M. Haghpassand, and E. M. Rubin Disruption of the Murine Lecithin:Cholesterol Acyltransferase Gene Causes Impairment of Adrenal Lipid Delivery and Up-regulation of Scavenger Receptor Class B Type I J. Biol. Chem., June 20, 1997; 272(25): 15777 - 15781. [Abstract] [Full Text] [PDF]

				W. V. Rodrigueza, K. J. Williams, G. H. Rothblat, and M. C. Phillips Remodeling and Shuttling: Mechanisms for the Synergistic Effects Between Different Acceptor Particles in the Mobilization of Cellular Cholesterol Arterioscler. Thromb. Vasc. Biol., February 1, 1997; 17(2): 383 - 393. [Abstract] [Full Text]

				A. Rigotti, E. R. Edelman, P. Seifert, S. N. Iqbal, R. B. DeMattos, R. E. Temel, M. Krieger, and D. L. Williams Regulation by Adrenocorticotropic Hormone of the in Vivo Expression of Scavenger Receptor Class B Type I (SR-BI), a High Density Lipoprotein Receptor, in Steroidogenic Cells of the Murine Adrenal Gland J. Biol. Chem., December 27, 1996; 271(52): 33545 - 33549. [Abstract] [Full Text] [PDF]

				T. Mizutani, K. Yamada, T. Minegishi, and K. Miyamoto Transcriptional Regulation of Rat Scavenger Receptor Class B Type I Gene J. Biol. Chem., July 14, 2000; 275(29): 22512 - 22519. [Abstract] [Full Text] [PDF]

				K. N. Liadaki, T. Liu, S. Xu, B. Y. Ishida, P. N. Duchateaux, J. P. Krieger, J. Kane, M. Krieger, and V. I. Zannis Binding of High Density Lipoprotein (HDL) and Discoidal Reconstituted HDL to the HDL Receptor Scavenger Receptor Class B Type I. EFFECT OF LIPID ASSOCIATION AND APOA-I MUTATIONS ON RECEPTOR BINDING J. Biol. Chem., July 7, 2000; 275(28): 21262 - 21271. [Abstract] [Full Text] [PDF]

				S. Urban, S. Zieseniss, M. Werder, H. Hauser, R. Budzinski, and B. Engelmann Scavenger Receptor BI Transfers Major Lipoprotein-associated Phospholipids into the Cells J. Biol. Chem., October 20, 2000; 275(43): 33409 - 33415. [Abstract] [Full Text] [PDF]

				T. A. Ramsamy, T. A.-M. Neville, B. M. Chauhan, D. Aggarwal, and D. L. Sparks Apolipoprotein A-I Regulates Lipid Hydrolysis by Hepatic Lipase J. Biol. Chem., October 20, 2000; 275(43): 33480 - 33486. [Abstract] [Full Text] [PDF]

				N. Wang, D. L. Silver, P. Costet, and A. R. Tall Specific Binding of ApoA-I, Enhanced Cholesterol Efflux, and Altered Plasma Membrane Morphology in Cells Expressing ABC1 J. Biol. Chem., October 13, 2000; 275(42): 33053 - 33058. [Abstract] [Full Text] [PDF]

				J. Han, A. C. Nicholson, X. Zhou, J. Feng, A. M. Gotto Jr., and D. P. Hajjar Oxidized Low Density Lipoprotein Decreases Macrophage Expression of Scavenger Receptor B-I J. Biol. Chem., May 4, 2001; 276(19): 16567 - 16572. [Abstract] [Full Text] [PDF]

				H. Tsuruoka, W. Khovidhunkit, B. E. Brown, J. W. Fluhr, P. M. Elias, and K. R. Feingold Scavenger Receptor Class B Type I Is Expressed in Cultured Keratinocytes and Epidermis. REGULATION IN RESPONSE TO CHANGES IN CHOLESTEROL HOMEOSTASIS AND BARRIER REQUIREMENTS J. Biol. Chem., January 18, 2002; 277(4): 2916 - 2922. [Abstract] [Full Text] [PDF]