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(Received for publication, April 26, 1996, and in revised form, June 10, 1996)
From the Department of Biochemistry, Boston University Medical
School, Boston, Massachusetts 02118
The insulin-like growth factor II
(IGF-II)/mannose 6-phosphate (Man-6-P) receptor recycles in adipose
cells between the cell surface and an intracellular storage pool, and
the rate of this trafficking is markedly enhanced by insulin. We show
here that the IGF-II/Man-6-P receptor is a constituent of the
GLUT4-containing compartment (``GLUT4 vesicles'') where it represents
gp230, a major recycling protein detected earlier by cell surface
biotinylation (Kandror, K. V., and Pilch, P. F. (1994) J. Biol. Chem. 269, 138-142). The GLUT4 vesicles include 10-15%
of the total and all of the acutely insulin-responsive recycling
population of the IGF-II/Man-6-P receptor. The main part of the
IGF-II/Man-6-P receptor population is excluded from the pathway of
GLUT4 trafficking and either resides permanently in intracellular
membranes or has a much slower rate of cycling to the cell surface.
Thus, GLUT4 vesicles mediate the insulin-dependent delivery
to the cell surface of the IGF-II/Man-6-P receptor as well as the other
recyclable proteins with extracellular functional domains (GLUT4 and
the aminopeptidase gp160).
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