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(Received for publication, April 24, 1996, and in revised form, June 14, 1996)
From the We describe the molecular cloning of two novel
human and murine transcription factors containing the TEA/ATTS DNA
binding domain and related to transcriptional enhancer factor-1
(TEF-1). These factors bind to the consensus TEA/ATTS cognate binding
site exemplified by the GT-IIC and Sph enhansons of the SV40 enhancer
but differ in their ability to bind cooperatively to tandemly repeated
sites. The human TEFs are differentially expressed in cultured cell
lines and the mouse (m)TEFs are differentially expressed in embryonic
and extra-embryonic tissues in early post-implantation embryos.
Strikingly, at later stages of embryogenesis, mTEF-3 is specifically
expressed in skeletal muscle precursors, whereas mTEF-1 is expressed
not only in developing skeletal muscle but also in the myocardium.
Together with previous data, these results point to important,
partially redundant, roles for these TEF proteins in myogenesis and
cardiogenesis. In addition, mTEF-1 is strongly coexpressed with mTEF-4
in mitotic neuroblasts, while accentuated mTEF-4 expression is also
observed in the gut and the nephrogenic region of the kidney. These
observations suggest additional roles for the TEF proteins in central
nervous system development and organogenesis.
Volume 271, Number 36,
Issue of September 6, 1996
pp. 21775-21785
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
¶
,
and
Institut de Génétique et de
Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP,
Collège de France, B.P. 163-67404 Illkirch Cédex,
France and the ¶ Laboratoire de Biologie Moléculaire et de
Genie Génétique, Institut de Chimie-B6, Université de
Liège, B-4000 Sart-Tilman, Belgium
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