JBC Transcription and Nuclear Factor Monoclonals

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Volume 271, Number 36, Issue of September 6, 1996 pp. 22081-22089
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

The B56 Family of Protein Phosphatase 2A (PP2A) Regulatory Subunits Encodes Differentiation-induced Phosphoproteins That Target PP2A to Both Nucleus and Cytoplasm

(Received for publication, April 1, 1996, and in revised form, June 17, 1996)

Brent McCright Dagger § , Ann M. Rivers Dagger § , Scott Audlin and David M. Virshup Dagger §par

From the Dagger  Division of Molecular Biology and Genetics, Department of Oncological Sciences, the § Program in Human Molecular Biology and Genetics, the  Combined Program in Molecular Biology, and the par  Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84112

Protein phosphatase 2A is a heterotrimeric protein serine/threonine phosphatase consisting of a 36-kDa catalytic C subunit, a 65-kDa structural A subunit, and a variable regulatory B subunit. The B subunits determine the substrate specificity of the enzyme. There have been three families of cellular B subunits identified to date: B55, B56 (B'), and PR72/130. We have now cloned five genes encoding human B56 isoforms. Polypeptides encoded by all but one splice variant (B56gamma 1) are phosphoproteins, as shown by mobility shift after treatment with alkaline phosphatase and metabolic labeling with [32P]phosphate. All labeled isoforms contain solely phosphoserine. Indirect immunofluorescence microscopy demonstrates distinct patterns of intracellular targeting by different B56 isoforms. Specifically, B56alpha , B56beta , and B56epsilon complexed with the protein phosphatase 2A A and C subunits localize to the cytoplasm, whereas B56delta , B56gamma 1, and B56gamma 3 are concentrated in the nucleus. Two isoforms (B56beta and B56delta ) are highly expressed in adult brain; here we show that mRNA for these isoforms increases severalfold when neuroblastoma cell lines are induced to differentiate by retinoic acid treatment. These studies demonstrate an increasing diversity of regulatory mechanisms to control the activity of this key intracellular protein phosphatase and suggest distinct functions for isoforms targeted to different intracellular locations.


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