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Volume 271, Number 37, Issue of September 13, 1996 pp. 22522-22527
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

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cDNA Cloning of a Novel Membrane Glycoprotein That Is Expressed Specifically in Glial Cells in the Mouse Brain
LIG-1, A PROTEIN WITH LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS

(Received for publication, April 26, 1996, and in revised form, July 1, 1996)

Yutaka Suzuki ^§ , Naoya Sato ^§ , Masaya Tohyama , Akio Wanaka and Tsutomu Takagi

From the  Department of Molecular Neurobiology (TANABE) and the  Department of Anatomy and Neuroscience, Osaka University Medical School, 2-2 Yamada-oka, Suita City, Osaka 565, Japan, and the ^§ Lead Generation Research Laboratory, Tanabe Seiyaku Co. Ltd., 3-16-89 Kashima, Yodogawa-ku, Osaka City, Osaka 532, Japan

A cDNA encoding a protein designated as LIG-1 has been cloned and characterized. A fragment of this cDNA was found previously in a screen for genes up-regulated during neural differentiation in mouse P19 embryonal carcinoma cells. Comparative sequence analysis revealed LIG-1 to be a novel integral membrane glycoprotein (1091 amino acids) containing an extracellular region (794 amino acids) with a potential signal peptide, 15 leucine-rich repeats, 3 immnunoglobulin-like domains, and 7 potential N-glycosylation sites, a transmembrane region of 23 amino acids, and a cytoplasmic region of 274 amino acids. This protein, therefore, is a new member of both the leucine-rich repeat and the immunoglobulin superfamilies. Furthermore, Northern blot and in situ hybridization analyses showed LIG-1 gene expression to be predominantly in the brain, restricted to a small subset of glial cells such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. On the basis of its structural features and expression pattern, we propose that LIG-1 functions as a cell type-specific adhesion molecule or receptor at the glial cell surface, and plays a role in the nervous system in for example neuroglial differentiation, development, and/or maintenance of neural functions where it is expressed.

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