| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, April 17, 1996)
,
,
,
and
From the Angiotensin II (AII) binds to specific G
protein-coupled receptors and is mitogenic in adrenal, liver
epithelial, and vascular smooth muscle cells. Since the cyclin
D1 gene encodes the regulatory subunit of the cyclin
D1-dependent kinase (CD1K) required for
phosphorylation of the retinoblastoma protein (pRB), an essential and
rate-limiting step in G1 phase progression of the cell
cycle, we examined the effect of AII on cyclin D1 expression and
CD1K activity in the human adrenal cell line H295R. AII
(10
Division of Endocrinology, Metabolism and
Molecular Medicine, and 
Division of Nephrology and Hypertension,
Department of Medicine, Northwestern University Medical School,
Chicago, Illinois 60611 and ¶ Department of Obstetrics and
Gynecology and Biochemistry, University of Texas Southwestern Medical
Center, Dallas, Texas 75235-9032
6 M) stimulated G1 phase
progression within 12 h, with a maximal effect after 72 h.
This action was antedated by the induction of cyclin D1 mRNA
(3-fold), cyclin D1 nuclear protein abundance (4-fold), and
CD1K activity (4-fold). AII induced cyclin D1 promoter
activity 4-fold, via the AT1 receptor through an enhancer
sequence at 
954 base pairs. c-Fos and c-Jun bound the cyclin D1 954
enhancer sequence, and the abundance of c-Fos within this complex was
increased by AII treatment. AII induced extracellular signal-regulated
kinase (ERK) activity 7-fold, and dominant-negative mutants of either
p21ras or ERK reduced AII-stimulated cyclin D1 promoter
activity. These findings suggest that AII may stimulate mitogenesis by
increasing CD1K activity through a
p21ras/ERK/activator protein 1 pathway.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Marampon, M. C. Casimiro, M. Fu, M. J. Powell, V. M. Popov, J. Lindsay, B. M. Zani, C. Ciccarelli, G. Watanabe, R. J. Lee, et al. Nerve Growth Factor Regulation of Cyclin D1 in PC12 Cells through a p21RAS Extracellular Signal-regulated Kinase Pathway Requires Cooperative Interactions between Sp1 and Nuclear Factor-{kappa}B Mol. Biol. Cell, June 1, 2008; 19(6): 2566 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Romero, S. Rilli, M. W. Plonczynski, L. L. Yanes, M. Y. Zhou, E. P. Gomez-Sanchez, and C. E. Gomez-Sanchez Adrenal transcription regulatory genes modulated by angiotensin II and their role in steroidogenesis Physiol Genomics, June 19, 2007; 30(1): 26 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G Ferreira, C. D Cruz, D. Neves, and D. Pignatelli Increased extracellular signal regulated kinases phosphorylation in the adrenal gland in response to chronic ACTH treatment J. Endocrinol., March 1, 2007; 192(3): 647 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wu, M. Liu, A. Li, H. Donninger, M. Rao, X. Jiao, M. P. Lisanti, A. Cvekl, M. Birrer, and R. G. Pestell Cell Fate Determination Factor DACH1 Inhibits c-Jun-induced Contact-independent Growth Mol. Biol. Cell, March 1, 2007; 18(3): 755 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Pestell and Z. Li Antisense to Cyclin D1 Inhibits VEGF-Stimulated Growth of Vascular Endothelial Cells: Implication of Tumor Vascularization Clin. Cancer Res., August 1, 2006; 12(15): 4459 - 4462. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Li, C. Wang, X. Jiao, Y. Lu, M. Fu, A. A. Quong, C. Dye, J. Yang, M. Dai, X. Ju, et al. Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling. Mol. Cell. Biol., June 1, 2006; 26(11): 4240 - 4256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Inagaki, F. Otsuka, J. Suzuki, Y. Kano, M. Takeda, T. Miyoshi, H. Otani, Y. Mimura, T. Ogura, and H. Makino Involvement of Bone Morphogenetic Protein-6 in Differential Regulation of Aldosterone Production by Angiotensin II and Potassium in Human Adrenocortical Cells Endocrinology, June 1, 2006; 147(6): 2681 - 2689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Ouyang, J. Li, Q. Ma, and C. Huang Essential roles of PI-3K/Akt/IKK{beta}/NF{kappa}B pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells Carcinogenesis, April 1, 2006; 27(4): 864 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. V. Yosypiv, M. Schroeder, and S. S. El-Dahr Angiotensin II Type 1 Receptor-EGF Receptor Cross-Talk Regulates Ureteric Bud Branching Morphogenesis J. Am. Soc. Nephrol., April 1, 2006; 17(4): 1005 - 1014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-G. LeHoux and A. Lefebvre Novel protein kinase C-epsilon inhibits human CYP11B2 gene expression through ERK1/2 signalling pathway and JunB J. Mol. Endocrinol., February 1, 2006; 36(1): 51 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Xiao, D. Chinnappan, R. Pestell, C. Albanese, and H. C. Weber Bombesin Regulates Cyclin D1 Expression through the Early Growth Response Protein Egr-1 in Prostate Cancer Cells Cancer Res., November 1, 2005; 65(21): 9934 - 9942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Otis, S. Campbell, M. D. Payet, and N. Gallo-Payet Angiotensin II Stimulates Protein Synthesis and Inhibits Proliferation in Primary Cultures of Rat Adrenal Glomerulosa Cells Endocrinology, February 1, 2005; 146(2): 633 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sancho, N. Marquez, M. Gomez-Gonzalo, M. A. Calzado, G. Bettoni, M. T. Coiras, J. Alcami, M. Lopez-Cabrera, G. Appendino, and E. Munoz Imperatorin Inhibits HIV-1 Replication through an Sp1-dependent Pathway J. Biol. Chem., September 3, 2004; 279(36): 37349 - 37359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D'Amico, K. Wu, M. Fu, M. Rao, C. Albanese, R. G. Russell, H. Lian, D. Bregman, M. A. White, and R. G. Pestell The Inhibitor of Cyclin-Dependent Kinase 4a/Alternative Reading Frame (INK4a/ARF) Locus Encoded Proteins p16INK4a and p19ARF Repress Cyclin D1 Transcription through Distinct cis Elements Cancer Res., June 15, 2004; 64(12): 4122 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Garnovskaya, Y. V. Mukhin, T. M. Vlasova, J. S. Grewal, M. E. Ullian, B. G. Tholanikunnel, and J. R. Raymond Mitogen-induced Rapid Phosphorylation of Serine 795 of the Retinoblastoma Gene Product in Vascular Smooth Muscle Cells Involves ERK Activation J. Biol. Chem., June 4, 2004; 279(23): 24899 - 24905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. SPAT and L. HUNYADY Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways Physiol Rev, April 1, 2004; 84(2): 489 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, R. E. Feltzer, K. L. Dawson, E. A. Hudson, and B. J. Clark Janus Kinase 2 and Calcium Are Required for Angiotensin II-dependent Activation of Steroidogenic Acute Regulatory Protein Transcription in H295R Human Adrenocortical Cells J. Biol. Chem., December 26, 2003; 278(52): 52355 - 52362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-L. Hu, C. Albanese, R. G. Pestell, and R. B. Jaffe Dual Mechanisms for Lysophosphatidic Acid Stimulation of Human Ovarian Carcinoma Cells J Natl Cancer Inst, May 21, 2003; 95(10): 733 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Levin Bidirectional Signaling between the Estrogen Receptor and the Epidermal Growth Factor Receptor Mol. Endocrinol., March 1, 2003; 17(3): 309 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gu, Y. Wen, A. Mison, and J. L. Nadler 12-Lipoxygenase Pathway Increases Aldosterone Production, 3',5'-Cyclic Adenosine Monophosphate Response Element-Binding Protein Phosphorylation, and p38 Mitogen-Activated Protein Kinase Activation in H295R Human Adrenocortical Cells Endocrinology, February 1, 2003; 144(2): 534 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Albanese, K. Wu, M. D'Amico, C. Jarrett, D. Joyce, J. Hughes, J. Hulit, T. Sakamaki, M. Fu, A. Ben-Ze'ev, et al. IKKalpha Regulates Mitogenic Signaling through Transcriptional Induction of Cyclin D1 via Tcf Mol. Biol. Cell, February 1, 2003; 14(2): 585 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Yan, D. Kim, T. Aizawa, and B. C. Berk Functional Interplay Between Angiotensin II and Nitric Oxide: Cyclic GMP as a Key Mediator Arterioscler. Thromb. Vasc. Biol., January 1, 2003; 23(1): 26 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Marino, F. Acconcia, F. Bresciani, A. Weisz, and A. Trentalance Distinct Nongenomic Signal Transduction Pathways Controlled by 17beta -Estradiol Regulate DNA Synthesis and Cyclin D1 Gene Transcription in HepG2 Cells Mol. Biol. Cell, October 1, 2002; 13(10): 3720 - 3729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S. KIRSCHNER Signaling Pathways in Adrenocortical Cancer Ann. N.Y. Acad. Sci., June 1, 2002; 968(1): 222 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Bearss, R. J. Lee, D. A. Troyer, R. G. Pestell, and J. J. Windle Differential Effects of p21WAF1/CIP1 Deficiency on MMTV-ras and MMTV-myc Mammary Tumor Properties Cancer Res., April 1, 2002; 62(7): 2077 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhao, R. Pestell, and J.-L. Guan Transcriptional Activation of Cyclin D1 Promoter by FAK Contributes to Cell Cycle Progression Mol. Biol. Cell, December 1, 2001; 12(12): 4066 - 4077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Guillemot, A. Levy, M. Raymondjean, and B. Rothhut Angiotensin II-induced Transcriptional Activation of the Cyclin D1 Gene Is Mediated by Egr-1 in CHO-AT1A Cells J. Biol. Chem., October 12, 2001; 276(42): 39394 - 39403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thibonnier, C. L. Plesnicher, K. Berrada, and L. Berti-Mattera Role of the human V1 vasopressin receptor COOH terminus in internalization and mitogenic signal transduction Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E81 - E92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, M. Fu, M. D'Amico, C. Albanese, J.-N. Zhou, M. Brownlee, M. P. Lisanti, V. K. K. Chatterjee, M. A. Lazar, and R. G. Pestell Inhibition of Cellular Proliferation through I{kappa}B Kinase-Independent and Peroxisome Proliferator-Activated Receptor {gamma}-Dependent Repression of Cyclin D1 Mol. Cell. Biol., May 1, 2001; 21(9): 3057 - 3070. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Lacroix, N. N'Diaye, J. Tremblay, and P. Hamet Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome Endocr. Rev., February 1, 2001; 22(1): 75 - 110. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. E. Laurance, D. B. Starr, E. F. Michelotti, E. Cheung, C. Gonzalez, A. W. Tam, J. Deikman, C. A. Edwards, and A. J. Bardwell Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells Nucleic Acids Res., February 1, 2001; 29(3): 652 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. N. Diep, M. El Mabrouk, R. M. Touyz, and E. L. Schiffrin Expression of Cell Cycle Proteins in Blood Vessels of Angiotensin II-Infused Rats : Role of AT1 Receptors Hypertension, February 1, 2001; 37(2): 604 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O. Henry, S. A. Moskalenko, K. J. Kaur, M. Fu, R. G. Pestell, J. H. Camonis, and M. A. White Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-kappa B Mol. Cell. Biol., November 1, 2000; 20(21): 8084 - 8092. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Lee, C. Albanese, M. Fu, M. D'Amico, B. Lin, G. Watanabe, G. K. Haines III, P. M. Siegel, M.-C. Hung, Y. Yarden, et al. Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway Mol. Cell. Biol., January 15, 2000; 20(2): 672 - 683. [Abstract] [Full Text]
|
|
|
|
|
|
C. Albanese, M. D'Amico, A. T. Reutens, M. Fu, G. Watanabe, R. J. Lee, R. N. Kitsis, B. Henglein, M. Avantaggiati, K. Somasundaram, et al. Activation of the cyclin D1 Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis J. Biol. Chem., November 26, 1999; 274(48): 34186 - 34195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kitazawa, R. Kitazawa, and S. Maeda Transcriptional Regulation of Rat Cyclin D1 Gene by CpG Methylation Status in Promoter Region J. Biol. Chem., October 1, 1999; 274(40): 28787 - 28793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Joyce, B. Bouzahzah, M. Fu, C. Albanese, M. D'Amico, J. Steer, J. U. Klein, R. J. Lee, J. E. Segall, J. K. Westwick, et al. Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-kappa B-dependent Pathway J. Biol. Chem., September 3, 1999; 274(36): 25245 - 25249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Carlson, T. Lahusen, S. Singh, A. Loaiza-Perez, P. J. Worland, R. Pestell, C. Albanese, E. A. Sausville, and A. M. Senderowicz Down-Regulation of Cyclin D1 by Transcriptional Repression in MCF-7 Human Breast Carcinoma Cells Induced by Flavopiridol Cancer Res., September 1, 1999; 59(18): 4634 - 4641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Pestell, C. Albanese, A. T. Reutens, J. E. Segall, R. J. Lee, and A. Arnold The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation Endocr. Rev., August 1, 1999; 20(4): 501 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pena, A. T. Reutens, C. Albanese, M. D’Amico, G. Watanabe, A. Donner, I-W. Shu, T. Williams, and R. G. Pestell Activator Protein-2 Mediates Transcriptional Activation of the CYP11A1 Gene by Interaction with Sp1 Rather than Binding to DNA Mol. Endocrinol., August 1, 1999; 13(8): 1402 - 1416. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Fujita, Y. Furukawa, N. Itabashi, Y. Tsuboi, M. Matsuda, K. Okada, and T. Saito Failure of cdc2 promoter activation and G2/M transition by ANG II and AVP in vascular smooth muscle cells Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H515 - H523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Ashton, G. Watanabe, C. Albanese, E. O. Harrington, J. A. Ware, and R. G. Pestell Protein Kinase Cdelta Inhibition of S-Phase Transition in Capillary Endothelial Cells Involves the Cyclin-dependent Kinase Inhibitor p27Kip1 J. Biol. Chem., July 23, 1999; 274(30): 20805 - 20811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ellinger-Ziegelbauer, K. Kelly, and U. Siebenlist Cell Cycle Arrest and Reversion of Ras-Induced Transformation by a Conditionally Activated Form of Mitogen-Activated Protein Kinase Kinase Kinase 3 Mol. Cell. Biol., May 1, 1999; 19(5): 3857 - 3868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Suzuki, D. Nagata, M. Kakoki, H. Hayakawa, A. Goto, M. Omata, and Y. Hirata Molecular Mechanisms of Endothelin-1–Induced Cell-Cycle Progression : Involvement of Extracellular Signal-Regulated Kinase, Protein Kinase C, and Phosphatidylinositol 3-Kinase at Distinct Points Circ. Res., March 19, 1999; 84(5): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Lee, C. Albanese, R. J. Stenger, G. Watanabe, G. Inghirami, G. K. Haines III, M. Webster, W. J. Muller, J. S. Brugge, R. J. Davis, et al. pp60v-src Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways. A ROLE FOR cAMP RESPONSE ELEMENT-BINDING PROTEIN AND ACTIVATING TRANSCRIPTION FACTOR-2 IN pp60v-src SIGNALING IN BREAST CANCER CELLS J. Biol. Chem., March 12, 1999; 274(11): 7341 - 7350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Smith, A. J. Baukal, P. Dent, and K. J. Catt Raf-1 Kinase Activation by Angiotensin II in Adrenal Glomerulosa Cells: Roles of Gi, Phosphatidylinositol 3-Kinase, and Ca2+ Influx Endocrinology, March 1, 1999; 140(3): 1385 - 1391. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. Beier, R. J. Lee, A. C. Taylor, R. G. Pestell, and P. LuValle Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes PNAS, February 16, 1999; 96(4): 1433 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Crandall, D. C. Armellino, D. E. Busler, B. McHendry-Rinde, and J. G. Kral Angiotensin II Receptors in Human Preadipocytes: Role in Cell Cycle Regulation Endocrinology, January 1, 1999; 140(1): 154 - 158. [Abstract] [Full Text]
|
|
|
|
|
|
P. K. Vadiveloo, G. Vairo, A. K. Royston, U. Novak, and J. A. Hamilton Proliferation-independent Induction of Macrophage Cyclin D2, and Repression of Cyclin D1, by Lipopolysaccharide J. Biol. Chem., September 4, 1998; 273(36): 23104 - 23109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Brown, E. Nigh, R. J. Lee, H. Ye, M. A. Thompson, F. Saudou, R. G. Pestell, and M. E. Greenberg Fos Family Members Induce Cell Cycle Entry by Activating Cyclin D1 Mol. Cell. Biol., September 1, 1998; 18(9): 5609 - 5619. [Abstract] [Full Text]
|
|
|
|
|
|
G. Watanabe, C. Albanese, R. J. Lee, A. Reutens, G. Vairo, B. Henglein, and R. G. Pestell Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1 Mol. Cell. Biol., June 1, 1998; 18(6): 3212 - 3222. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. E. Aplin, A. Howe, S. K. Alahari, and R. L. Juliano Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins Pharmacol. Rev., June 1, 1998; 50(2): 197 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tian, R. D. Smith, T. Balla, and K. J. Catt Angiotensin II Activates Mitogen-Activated Protein Kinase Via Protein Kinase C and Ras/Raf-1 Kinase in Bovine Adrenal Glomerulosa Cells Endocrinology, April 1, 1998; 139(4): 1801 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Weber, W. Hu, S. C. Jefcoat Jr., D. M. Raben, and J. J. Baldassare Ras-stimulated Extracellular Signal-related Kinase 1 and RhoA Activities Coordinate Platelet-derived Growth Factor-induced G1 Progression through the Independent Regulation of Cyclin D1 and p27KIP1 J. Biol. Chem., December 26, 1997; 272(52): 32966 - 32971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Watanabe, P. Pena, C. Albanese, L. D. Wilsbacher, J. B. Young, and R. G. Pestell Adrenocorticotropin Induction of Stress-activated Protein Kinase in the Adrenal Cortex in Vivo J. Biol. Chem., August 8, 1997; 272(32): 20063 - 20069. [Abstract] [Full Text] [PDF]
|
|
