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(Received for publication, March 18, 1996, and in revised form, June 12, 1996)
From the Departments of We report preliminary characterization of a gene
designated
Volume 271, Number 37,
Issue of September 13, 1996
pp. 22878-22884
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
-R1, a Gene That Is Selectively Induced by
Interferon (IFN-) Compared with IFN-
,
Neurosciences and
¶ Molecular Biology, Research Institute, The Cleveland Clinic
Foundation, Cleveland, Ohio 44195, and § Department of
Medicine, Imperial College School of Medicine, St. Mary's Hospital,
Norfolk, London W2I NY, United Kingdom
-R1, which is selectively expressed in response to
interferon (IFN-) compared with IFN-
. In human astrocytoma
cells, -R1 was induced to an equivalent extent by 10 IU/mL IFN-
or 2500 IU/mL IFN-2. To address the mechanism of this differential
response, we analyzed induction of the -R1 gene in fibrosarcoma
cells and derivative mutant cells lacking components required for
signaling by type I IFNs. -R1 was readily induced by IFN- in the
parental 2fTGH cell line, but not by recombinant IFN-2, IFN-
Con1, or a mixture of IFN- subtypes. IFN-8 induced -R1 weakly.
-R1 was not induced by IFN- in mutant cell lines U2A, U3A, U4A,
and U6A, which lack, respectively, p48, STAT1, JAK1, and STAT2. U5A
cells, which lack the Ifnar 2.2 component of the IFN- and -
receptor, also failed to express -R1. U1A cells are partially
responsive to IFN- and IFN-8 but lacked -R1 expression,
indicating that TYK2 protein is essential for induction of this gene.
Taken together, these results suggest that the expression of -R1 in
response to type I IFN requires IFN-stimulated gene factor 3 plus an
additional component, which is more efficiently formed on induction by
IFN- compared with IFN-.
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D. Russell-Harde, T. C. Wagner, M. R. S. Rani, D. Vogel, O. Colamonici, R. M. Ransohoff, B. Majchrzak, E. Fish, H. D. Perez, and E. Croze Role of the Intracellular Domain of the Human Type I Interferon Receptor 2 Chain (IFNAR2c) in Interferon Signaling. EXPRESSION OF IFNAR2c TRUNCATION MUTANTS IN U5A CELLS J. Biol. Chem., July 28, 2000; 275(31): 23981 - 23985. [Abstract] [Full Text] [PDF]
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