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Volume 271, Number 44, Issue of November 1, 1996 pp. 27197-27200
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

A p56lck Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor

(Received for publication, July 17, 1996)

Sandra L. Marcus Dagger , Christopher J. Winrow Dagger , John P. Capone and Richard A. Rachubinski Dagger

From the Dagger  Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada and  Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada

Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, COUP-TFII stimulates transcription directly. A cellular factor, isolated by interaction cloning, bound COUP-TFII in vitro and allowed COUP-TFII to function as a transcriptional activator in mammalian cells. This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56lck, suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways.


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