|
|
|
|||||||
|
|||||||||
(Received for publication, January 23, 1996, and in revised form, June 1, 1996)
From the § Department of Biochemistry and
We have recently demonstrated that the growth of
murine macrophages is induced by oxidized low density lipoprotein
(Ox-LDL) and that lysophosphatidylcholine (lyso-PC), a major
phospholipid component of Ox-LDL, plays an essential role in its
mitogenic effect. The present study was undertaken to further
characterize the role of the macrophage scavenger receptor (MSR) in
Ox-LDL-induced macrophage growth. The growth-stimulating effect of
Ox-LDL on murine resident peritoneal macrophages was inhibited by
maleylated bovine serum albumin (maleyl-BSA), a non-lipoprotein ligand
for MSR but a poor carrier of lyso-PC, while maleyl-BSA itself failed
to induce macrophage growth even in the presence of lyso-PC. Moreover,
it competitively inhibited the endocytic uptake of
125I-Ox-LDL and the specific uptake of lyso-PC by MSR,
whereas nonspecific lyso-PC transfer to cells was not affected.
Furthermore, the Ox-LDL-induced cell growth of peritoneal macrophages
obtained from MSR knockout mice was significantly weaker than that of
macrophages obtained from their wild-type littermates. Our results
suggest that the MSR is an important and efficient internalization
pathway for lyso-PC in Ox-LDL-induced macrophage growth.
Volume 271, Number 44,
Issue of November 1, 1996
pp. 27346-27352
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
,
,
and
Department of Metabolic Medicine, Kumamoto University
School of Medicine, Honjo 2-2-1, Kumamoto 860, Japan and ¶ The
Third Department of Internal Medicine, Faculty of Medicine, The
University of Tokyo, Tokyo 113, Japan
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. DeVries-Seimon, Y. Li, P. M. Yao, E. Stone, Y. Wang, R. J. Davis, R. Flavell, and I. Tabas Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor J. Cell Biol., October 10, 2005; 171(1): 61 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fukuhara-Takaki, M. Sakai, Y.-i. Sakamoto, M. Takeya, and S. Horiuchi Expression of Class A Scavenger Receptor Is Enhanced by High Glucose in Vitro and under Diabetic Conditions in Vivo: ONE MECHANISM FOR AN INCREASED RATE OF ATHEROSCLEROSIS IN DIABETES J. Biol. Chem., February 4, 2005; 280(5): 3355 - 3364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.J. Chapman Are the effects of statins on HDL-cholesterol clinically relevant? Eur. Heart J. Suppl., July 1, 2004; 6(suppl_C): C58 - C63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C McGill Jr, C A. McMahan, E. E Herderick, G. T Malcom, R. E Tracy, and J. P Strong Origin of atherosclerosis in childhood and adolescence Am. J. Clinical Nutrition, November 1, 2000; 72 (5): 1307S - 1315S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Biwa, M. Sakai, T. Matsumura, S. Kobori, K. Kaneko, A. Miyazaki, H. Hakamata, S. Horiuchi, and M. Shichiri Sites of Action of Protein Kinase C and Phosphatidylinositol 3-Kinase Are Distinct in Oxidized Low Density Lipoprotein-induced Macrophage Proliferation J. Biol. Chem., February 25, 2000; 275(8): 5810 - 5816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. J. de Winther, K. W. van Dijk, L. M. Havekes, and M. H. Hofker Macrophage Scavenger Receptor Class A : A Multifunctional Receptor in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., February 1, 2000; 20(2): 290 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lehtolainen, M. Takeya, and S. Yla-Herttuala Retrovirus-Mediated, Stable Scavenger-Receptor Gene Transfer Leads to Functional Endocytotic Receptor Expression, Foam Cell Formation, and Increased Susceptibility to Apoptosis in Rabbit Aortic Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 52 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gomez-Munoz, J. S. Martens, and U. P. Steinbrecher Stimulation of Phospholipase D Activity by Oxidized LDL in Mouse Peritoneal Macrophages Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 135 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsumura, M. Sakai, K. Matsuda, N. Furukawa, K. Kaneko, and M. Shichiri Cis-acting DNA Elements of Mouse Granulocyte/Macrophage Colony-stimulating Factor Gene Responsive to Oxidized Low Density Lipoprotein J. Biol. Chem., December 31, 1999; 274(53): 37665 - 37672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Fong and D. Le The Processing of Ligands by the Class A Scavenger Receptor Is Dependent on Signal Information Located in the Cytoplasmic Domain J. Biol. Chem., December 17, 1999; 274(51): 36808 - 36816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sakai, T. Biwa, T. Matsumura, T. Takemura, H. Matsuda, Y. Anami, T. Sasahara, S. Kobori, and M. Shichiri Glucocorticoid Inhibits Oxidized LDL-Induced Macrophage Growth by Suppressing the Expression of Granulocyte/Macrophage Colony-Stimulating Factor Arterioscler. Thromb. Vasc. Biol., July 1, 1999; 19(7): 1726 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Martens, M. Lougheed, A. Gomez-Munoz, and U. P. Steinbrecher A Modification of Apolipoprotein B Accounts for Most of the Induction of Macrophage Growth by Oxidized Low Density Lipoprotein J. Biol. Chem., April 16, 1999; 274(16): 10903 - 10910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Biwa, H. Hakamata, M. Sakai, A. Miyazaki, H. Suzuki, T. Kodama, M. Shichiri, and S. Horiuchi Induction of Murine Macrophage Growth by Oxidized Low Density Lipoprotein Is Mediated by Granulocyte Macrophage Colony-stimulating Factor J. Biol. Chem., October 23, 1998; 273(43): 28305 - 28313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Botas, F. Poulain, J. Akiyama, C. Brown, L. Allen, J. Goerke, J. Clements, E. Carlson, A. M. Gillespie, C. Epstein, et al. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D PNAS, September 29, 1998; 95(20): 11869 - 11874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Stengel, M. Antonucci, W. Gaoua, C. Dachet, P. Lesnik, D. Hourton, E. Ninio, M. J. Chapman, and S. Griglio Inhibition of LPL Expression in Human Monocyte–Derived Macrophages Is Dependent on LDL Oxidation State : A Key Role for Lysophosphatidylcholine Arterioscler. Thromb. Vasc. Biol., July 1, 1998; 18(7): 1172 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Camejo, C. Halberg, A. Manschik-Lundin, E. Hurt-Camejo, B. Rosengren, H. Olsson, G. I. Hansson, G.-B. Forsberg, and B. Ylhen Hemin binding and oxidation of lipoproteins in serum: mechanisms and effect on the interaction of LDL with human macrophages J. Lipid Res., April 1, 1998; 39(4): 755 - 766. [Abstract] [Full Text]
|
|
|
|
|
|
H. Hakamata, A. Miyazaki, M. Sakai, H. Matsuda, H. Suzuki, T. Kodama, and S. Horiuchi Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein J. Lipid Res., March 1, 1998; 39(3): 482 - 494. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Martens, N. E. Reiner, P. Herrera-Velit, and U. P. Steinbrecher Phosphatidylinositol 3-Kinase Is Involved in the Induction of Macrophage Growth by Oxidized Low Density Lipoprotein J. Biol. Chem., February 27, 1998; 273(9): 4915 - 4920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. De Vries, E. Ronken, J.-h. Reinders, B. Buchner, T. J. C. van berkel, and J. Kuiper Acute effects of oxidized low density lipoprotein on metabolic responses in macrophages FASEB J, January 1, 1998; 12(1): 111 - 118. [Abstract] [Full Text]
|
|
|
|
|
|
T. Matsumura, M. Sakai, S. Kobori, T. Biwa, T. Takemura, H. Matsuda, H. Hakamata, S. Horiuchi, and M. Shichiri Two Intracellular Signaling Pathways for Activation of Protein Kinase C Are Involved in Oxidized Low-Density Lipoprotein–Induced Macrophage Growth Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 3013 - 3020. [Abstract] [Full Text]
|
|
|
|
|
|
D. P. Hajjar and M. E. Haberland Lipoprotein Trafficking in Vascular Cells. MOLECULAR TROJAN HORSES AND CELLULAR SABOTEURS J. Biol. Chem., September 12, 1997; 272(37): 22975 - 22978. [Full Text] [PDF]
|
|
|
|
|
|
M. Lougheed, C. M. Lum, W. Ling, H. Suzuki, T. Kodama, and U. Steinbrecher High Affinity Saturable Uptake of Oxidized Low Density Lipoprotein by Macrophages from Mice Lacking the Scavenger Receptor Class A Type I/II J. Biol. Chem., May 16, 1997; 272(20): 12938 - 12944. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |