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(Received for publication, August 7, 1996, and in revised form, August 26, 1996)
From the Thyroid Unit, Department of Medicine, Beth Israel Hospital
and Harvard Medical School, Boston, Massachusetts 02215
Recently, a family of nuclear co-repressor
proteins (TRACs) have been identified that interact with thyroid
hormone (TR) and retinoic acid receptors to mediate ligand-independent
repression of gene transcription. In this report, we have cloned and
characterized a human TRAC, which when expressed as a truncated protein
lacking its repressing domains, can abolish endogenous cellular TRAC
activity. Use of this inhibitor has uncovered a differential function
of TRACs on negative versus positive thyroid hormone
response elements and has demonstrated the importance of the TR A/B
domain in modulating TRAC function. Thus, isoform-specific functions of
the TR may be mediated by their functional interaction with
co-repressor proteins.
Volume 271, Number 45,
Issue of November 8, 1996
pp. 28516-28520
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
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