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Volume 271, Number 46, Issue of November 15, 1996 pp. 28738-28740
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

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COMMUNICATION:
The Retinoblastoma Family Member p107 Binds to B-MYB and Suppresses Its Autoregulatory Activity

(Received for publication, August 5, 1996)

Arturo Sala , Antonio De Luca ^¶ , Antonio Giordano ^¶ and Cesare Peschle

From the  Kimmel Cancer Institute, Department of Microbiology-Immunology and ^¶ Pathology, Anatomy & Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107 and the  Laboratorio di Ematologia Oncologia Istituto Superiore di Sanità, Rome, Italy

It was recently reported that B-MYB can overcome p107-induced growth arrest. Here we show that B-MYB autoregulation of its own transcription is specifically suppressed by p107 and transient transfection assays with p107 deletion constructs determined that the carboxyl terminus of the protein, containing the major pocket region, was associated with inhibition of B-MYB-dependent transactivation. Consistent with these results, co-immunoprecipitation studies showed that p107 interacted in vivo with B-MYB through its pocket and carboxyl terminus domain. Thus, B-MYB-dependent promotion of cell proliferation and gene transactivation might be specifically repressed by the growth suppressor p107 through direct interaction with B-MYB.

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