|
|
|
|||||||
|
|||||||||
(Received for publication, April 9, 1996, and in revised form, July 9, 1996)
From the Division of Bone and Mineral Diseases and the
To analyze how estrogen blocks
osteoclastogenesis, we investigated the effects of ovariectomy on
osteoclast (OC) formation in co-cultures of purified OC precursors and
purified stromal cells (SC). OC formation was higher in co-cultures
containing SC from ovariectomized mice than in those containing SC from
sham-operated mice, thus suggesting that estrogen regulates
osteoclastogenesis by targeting SC. Ovariectomy also increased the
mononuclear cell secretion of interleukin (IL)-1) and tumor necrosis
factor (TNF) and the SC production of macrophage colony-stimulating
factor (MCSF). Osteoclastogenesis and SC production of M-CSF were
not blocked by in vitro estrogen treatment but were
decreased by in vivo treatment of donor mice with either
estrogen or a combination of the IL-1 inhibitor, IL-1 receptor
antagonist, and the TNF inhibitor, TNF binding protein. IL-1 and TNF
production were also blocked by in vivo estrogen treatment,
demonstrating that the increased bone marrow levels of IL-1 and TNF
characteristic of ovariectomized mice induce the formation of a SC
population characterized by a high production of M-CSF and increased
pro-osteoclastogenic activity. Since in co-cultures of SC and OC
precursors M-CSF levels correlated with OC production
(r = 0.7, p < 0.0001), the data also
indicate that the pro-osteoclastogenic activity of SC is proportional
to their secretion of M-CSF. The ability of estrogen to decrease SC
production of M-CSF and the pro-osteoclastogenic activity of these
cells by regulating IL-1 and TNF production is a previously undescribed
mechanism by which estrogen down-regulates osteoclastogenesis.
Volume 271, Number 46,
Issue of November 15, 1996
pp. 28890-28897
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
,
Department of Pathology, Washington University School of
Medicine and Barnes/Jewish Hospital, St. Louis, Missouri 63110
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  G.-Q. Yao, J.-J. Wu, S. Ovadia, N. Troiano, B. H. Sun, and K. Insogna Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E714 - E720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kitaura, M. Yoshimatsu, Y. Fujimura, T. Eguchi, H. Kohara, A. Yamaguchi, and N. Yoshida An Anti-c-Fms Antibody Inhibits Orthodontic Tooth Movement Journal of Dental Research, April 1, 2008; 87(4): 396 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ohno, K. Kubo, H. Murooka, Y. Kobayashi, T. Nishitoba, M. Shibuya, T. Yoneda, and T. Isoe A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol. Cancer Ther., November 1, 2006; 5(11): 2634 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U.H. Lerner Bone Remodeling in Post-menopausal Osteoporosis Journal of Dental Research, July 1, 2006; 85(7): 584 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Huang, S. Cao, M. Nagamani, K. E. Anderson, J. J. Grady, and L.-J. W. Lu Decreased Circulating Levels of Tumor Necrosis Factor-{alpha} in Postmenopausal Women during Consumption of Soy-Containing Isoflavones J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 3956 - 3962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Yogesha, S. M. Khapli, and M. R. Wani Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Inhibits Tumor Necrosis Factor (TNF)-{alpha}-induced Osteoclast Differentiation by Down-regulation of Expression of TNF Receptors 1 and 2 J. Biol. Chem., March 25, 2005; 280(12): 11759 - 11769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-S. Wang, C.-J. Wang, Y.-J. Chen, Y.-T. Huang, H.-C. Huang, P.-R. Chang, Y.-C. Sun, and K. D. Yang Nitric Oxide Donor Increases Osteoprotegerin Production and Osteoclastogenesis Inhibitory Activity in Bone Marrow Stromal Cells from Ovariectomized Rats Endocrinology, May 1, 2004; 145(5): 2148 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Rude, H. E. Gruber, H. J. Norton, L. Y. Wei, A. Frausto, and B. G. Mills Bone Loss Induced by Dietary Magnesium Reduction to 10% of the Nutrient Requirement in Rats Is Associated with Increased Release of Substance P and Tumor Necrosis Factor-{alpha} J. Nutr., January 1, 2004; 134(1): 79 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ishimaru, R. Arakaki, M. Watanabe, M. Kobayashi, K. Miyazaki, and Y. Hayashi Development of Autoimmune Exocrinopathy Resembling Sjogren's Syndrome in Estrogen-Deficient Mice of Healthy Background Am. J. Pathol., October 1, 2003; 163(4): 1481 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zou, A. Amcheslavsky, and Z. Bar-Shavit CpG Oligodeoxynucleotides Modulate the Osteoclastogenic Activity of Osteoblasts via Toll-like Receptor 9 J. Biol. Chem., May 2, 2003; 278(19): 16732 - 16740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cuzzocrea, E. Mazzon, L. Dugo, T. Genovese, R. Di Paola, Z. Ruggeri, E. Vegeto, A. P. Caputi, F. A. J. Van de Loo, D. Puzzolo, et al. Inducible Nitric Oxide Synthase Mediates Bone Loss in Ovariectomized Mice Endocrinology, March 1, 2003; 144(3): 1098 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kitaura, N. Nagata, Y. Fujimura, H. Hotokezaka, N. Yoshida, and K. Nakayama Effect of IL-12 on TNF-{alpha}-Mediated Osteoclast Formation in Bone Marrow Cells: Apoptosis Mediated by Fas/Fas Ligand Interaction J. Immunol., November 1, 2002; 169(9): 4732 - 4738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Riggs, S. Khosla, and L. J. Melton III Sex Steroids and the Construction and Conservation of the Adult Skeleton Endocr. Rev., June 1, 2002; 23(3): 279 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fuller, C. Murphy, B. Kirstein, S. W. Fox, and T. J. Chambers TNF{alpha} Potently Activates Osteoclasts, through a Direct Action Independent of and Strongly Synergistic with RANKL Endocrinology, March 1, 2002; 143(3): 1108 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz Changes in Proinflammatory Cytokine Activity after Menopause Endocr. Rev., February 1, 2002; 23(1): 90 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kim, M. Takami, J. Rho, R. Josien, and Y. Choi A Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation J. Exp. Med., January 14, 2002; 195(2): 201 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Parikka, P. Lehenkari, M.-L. Sassi, J. Halleen, J. Risteli, P. Harkonen, and H. K. Vaananen Estrogen Reduces the Depth of Resorption Pits by Disturbing the Organic Bone Matrix Degradation Activity of Mature Osteoclasts Endocrinology, December 1, 2001; 142(12): 5371 - 5378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Roggia, Y. Gao, S. Cenci, M. N. Weitzmann, G. Toraldo, G. Isaia, and R. Pacifici Up-regulation of TNF-producing T cells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo PNAS, November 20, 2001; 98(24): 13960 - 13965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Watkins, Y. Li, and M. F. Seifert Nutraceutical Fatty Acids as Biochemical and Molecular Modulators of Skeletal Biology J. Am. Coll. Nutr., October 1, 2001; 20(90005): 410S - 416. [Abstract] [Full Text]
|
|
|
|
|
|
M. Saika, D. Inoue, S. Kido, and T. Matsumoto 17{beta}-Estradiol Stimulates Expression of Osteoprotegerin by a Mouse Stromal Cell Line, ST-2, via Estrogen Receptor-{{alpha}} Endocrinology, June 1, 2001; 142(6): 2205 - 2212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Watkins, Y. Li, H. E. Lippman, and M. F. Seifert Omega-3 Polyunsaturated Fatty Acids and Skeletal Health Experimental Biology and Medicine, June 1, 2001; 226(6): 485 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Compston Sex Steroids and Bone Physiol Rev, January 1, 2001; 81(1): 419 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Fan, D. Fan, H. Gewant, C. L. Royce, M. S. Nanes, and J. Rubin Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E103 - E111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Teitelbaum Bone Resorption by Osteoclasts Science, September 1, 2000; 289(5484): 1504 - 1508. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. N. Weitzmann, S. Cenci, L. Rifas, C. Brown, and R. Pacifici Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines Blood, September 1, 2000; 96(5): 1873 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Spelsberg, M. Subramaniam, B. L. Riggs, and S. Khosla The Actions and Interactions of Sex Steroids and Growth Factors/Cytokines on the Skeleton Mol. Endocrinol., June 1, 1999; 13(6): 819 - 828. [Full Text]
|
|
|
|
|
|
C. K. Lea, U. Sarma, and A. M. Flanagan Macrophage Colony Stimulating-Factor Transcripts Are Differentially Regulated in Rat Bone-Marrow by Gender Hormones Endocrinology, January 1, 1999; 140(1): 273 - 279. [Abstract] [Full Text]
|
|
|
|
|
|
R. Pacifici Editorial: Cytokines, Estrogen, and Postmenopausal Osteoporosis--The Second Decade Endocrinology, June 1, 1998; 139(6): 2659 - 2661. [Full Text] [PDF]
|
|
|
|
|
|
J. Rubin, D. M. Biskobing, L. Jadhav, D. Fan, M. S. Nanes, S. Perkins, and X. Fan Dexamethasone Promotes Expression of Membrane-Bound Macrophage Colony-Stimulating Factor in Murine Osteoblast-Like Cells Endocrinology, March 1, 1998; 139(3): 1006 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Elhage, A. Maret, M.-T. Pieraggi, J. C. Thiers, J. F. Arnal, and F. Bayard Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice Circulation, January 27, 1998; 97(3): 242 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Biskobing, D. Fan, X. Fan, and J. Rubin Induction of Carbonic Anhydrase II Expression in Osteoclast Progenitors Requires Physical Contact with Stromal Cells Endocrinology, November 1, 1997; 138(11): 4852 - 4857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Abu-Amer, J. Erdmann, L. Alexopoulou, G. Kollias, F. P. Ross, and S. L. Teitelbaum Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoclastogenesis J. Biol. Chem., August 25, 2000; 275(35): 27307 - 27310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Katagiri, Y. Hakeda, D. Chikazu, T. Ogasawara, T. Takato, M. Kumegawa, K. Nakamura, and H. Kawaguchi Mechanism of Stimulation of Osteoclastic Bone Resorption through Gas6/Tyro 3, a Receptor Tyrosine Kinase Signaling, in Mouse Osteoclasts J. Biol. Chem., March 2, 2001; 276(10): 7376 - 7382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Srivastava, G. Toraldo, M. N. Weitzmann, S. Cenci, F. P. Ross, and R. Pacifici Estrogen Decreases Osteoclast Formation by Down-regulating Receptor Activator of NF-kappa B Ligand (RANKL)-induced JNK Activation J. Biol. Chem., March 16, 2001; 276(12): 8836 - 8840. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |