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(Received for publication, March 28, 1996, and in revised form, July 30, 1996)
From the Department of Medicine, The nuclear body (NB) is a cellular organelle
that is involved in the pathogenesis of acute promyelocytic leukemia
and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In
this study, serum from a patient with primary biliary cirrhosis was
used to identify a cDNA encoding a novel component of the NB, a
140-kDa protein designated Sp140. The predicted amino acid sequence of
the amino-terminal portion of Sp140 was similar to Sp100, a previously
identified NB protein. The carboxyl portion of Sp140 contained a
zinc-finger domain and a bromodomain, motifs that are present in
proteins regulating gene transcription. High levels of Sp140 mRNA
were detected in human spleen and peripheral blood leukocytes, but not
other human tissues. The level of SP140 mRNA in myeloid precursor
cell lines HL60 and NB4 markedly increased in response to chemically
induced cellular differentiation. Immunohistochemical techniques were
used to demonstrate that SP140 localized to the NB in differentiated
HL60 and NB4 cells. The location of Sp140 in the NB, and expression of
this gene in cells involved in host defense, suggest that Sp140 may be
involved in the pathogenesis of acute promyelocytic leukemia and viral
infection.
Volume 271, Number 46,
Issue of November 15, 1996
pp. 29198-29204
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
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Cardiovascular Research Center,
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