| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, July 23, 1996, and in revised form, August 20, 1996)
From the Department of Health Chemistry, School of Pharmaceutical
Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku,
Tokyo 142, Japan
Type II secretory phospholipase A2
(sPLA2) has been shown to be induced by a variety of
proinflammatory stimuli and, therefore, has been implicated in the
inflammatory process. In order to determine whether association of
sPLA2 with cell surfaces via heparan sulfate proteoglycan
is important for its effects on cellular functions, we have identified
the critical domain in sPLA2 for heparin and cell surface
binding and examined its role in cellular prostaglandin (PG)
biosynthesis. Replacement of several conserved Lys residues in the
C-terminal region of mouse and rat sPLA2s by Glu resulted in a marked reduction of their capacities to bind to heparin and mammalian cell surfaces without affecting their enzymatic activities toward dispersed phospholipid as a substrate. CHO cells stably transfected with wild-type sPLA2 released about twice as
much arachidonic acid (AA) during culture for 10 h with fetal calf serum and interleukin-1
Volume 271, Number 47,
Issue of November 22, 1996
pp. 30041-30051
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
than cells transfected with vector alone, whereas the ability to enhance AA release was impaired in
sPLA2 mutants incapable of binding to cell surfaces. AA
released by wild-type sPLA2-transfected CHO cells was
metabolized to prostaglandin E2 via prostaglandin
endoperoxide H synthase (PGHS)-2 after IL-1 stimulation, revealing a
particular functional linkage of sPLA2 to PGHS-2. In
contrast, A23187-initiated immediate AA release over 30 min was not
affected by sPLA2 overexpression. Taken together, these
results suggest that sPLA2 expressed endogenously and
anchored on cell surfaces via its C-terminal heparin-binding domain is involved in the PGHS-2-dependent delayed PG biosynthesis
initiated by growth factors and cytokines during long term culture.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Zhou, T.-C. Tan, S. Valiyaveettil, M. L. Go, R. M. Kini, A. Velazquez-Campoy, and J. Sivaraman Structural Characterization of Myotoxic Ecarpholin S From Echis carinatus Venom Biophys. J., October 1, 2008; 95(7): 3366 - 3380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kuwata, C. Fujimoto, E. Yoda, S. Shimbara, Y. Nakatani, S. Hara, M. Murakami, and I. Kudo A Novel Role of Group VIB Calcium-independent Phospholipase A2 (iPLA2{gamma}) in the Inducible Expression of Group IIA Secretory PLA2 in Rat Fibroblastic Cells J. Biol. Chem., July 13, 2007; 282(28): 20124 - 20132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Wijewickrama, A. Albanese, Y. J. Kim, Y. S. Oh, P. S. Murray, R. Takayanagi, T. Tobe, S. Masuda, M. Murakami, I. Kudo, et al. Unique Membrane Interaction Mode of Group IIF Phospholipase A2 J. Biol. Chem., October 27, 2006; 281(43): 32741 - 32754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ni, N. M. Okeley, B. P. Smart, and M. H. Gelb Intracellular Actions of Group IIA Secreted Phospholipase A2 and Group IVA Cytosolic Phospholipase A2 Contribute to Arachidonic Acid Release and Prostaglandin Production in Rat Gastric Mucosal Cells and Transfected Human Embryonic Kidney Cells J. Biol. Chem., June 16, 2006; 281(24): 16245 - 16255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Wijewickrama, J.-H. Kim, Y. J. Kim, A. Abraham, Y. Oh, B. Ananthanarayanan, M. Kwatia, S. J. Ackerman, and W. Cho Systematic Evaluation of Transcellular Activities of Secretory Phospholipases A2: HIGH ACTIVITY OF GROUP V PHOSPHOLIPASES A2 TO INDUCE EICOSANOID BIOSYNTHESIS IN NEIGHBORING INFLAMMATORY CELLS J. Biol. Chem., April 21, 2006; 281(16): 10935 - 10944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Femling, W. M. Nauseef, and J. P. Weiss Synergy between Extracellular Group IIA Phospholipase A2 and Phagocyte NADPH Oxidase in Digestion of Phospholipids of Staphylococcus aureus Ingested by Human Neutrophils J. Immunol., October 1, 2005; 175(7): 4653 - 4661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kuwata, T. Nonaka, M. Murakami, and I. Kudo Search of Factors That Intermediate Cytokine-induced Group IIA Phospholipase A2 Expression through the Cytosolic Phospholipase A2- and 12/15-Lipoxygenase-dependent Pathway J. Biol. Chem., July 8, 2005; 280(27): 25830 - 25839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jaulmes, B. Janvier, M. Andreani, and M. Raymondjean Autocrine and Paracrine Transcriptional Regulation of Type IIA Secretory Phospholipase A2 Gene in Vascular Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., June 1, 2005; 25(6): 1161 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Triggiani, F. Granata, B. Balestrieri, A. Petraroli, G. Scalia, L. Del Vecchio, and G. Marone Secretory Phospholipases A2 Activate Selective Functions in Human Eosinophils J. Immunol., March 15, 2003; 170(6): 3279 - 3288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, S. Masuda, S. Shimbara, S. Bezzine, M. Lazdunski, G. Lambeau, M. H. Gelb, S. Matsukura, F. Kokubu, M. Adachi, et al. Cellular Arachidonate-releasing Function of Novel Classes of Secretory Phospholipase A2s (Groups III and XII) J. Biol. Chem., March 14, 2003; 278(12): 10657 - 10667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, K. Yoshihara, S. Shimbara, G. Lambeau, M. H. Gelb, A. G. Singer, M. Sawada, N. Inagaki, H. Nagai, M. Ishihara, et al. Cellular Arachidonate-releasing Function and Inflammation-associated Expression of Group IIF Secretory Phospholipase A2 J. Biol. Chem., May 17, 2002; 277(21): 19145 - 19155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Enomoto, M. Murakami, E. Valentin, G. Lambeau, M. H. Gelb, and I. Kudo Redundant and Segregated Functions of Granule-Associated Heparin-Binding Group II Subfamily of Secretory Phospholipases A2 in the Regulation of Degranulation and Prostaglandin D2 Synthesis in Mast Cells J. Immunol., October 1, 2000; 165(7): 4007 - 4014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kuwata, S. Yamamoto, Y. Miyazaki, S. Shimbara, Y. Nakatani, H. Suzuki, N. Ueda, S. Yamamoto, M. Murakami, and I. Kudo Studies on a Mechanism by Which Cytosolic Phospholipase A2 Regulates the Expression and Function of Type IIA Secretory Phospholipase A2 J. Immunol., October 1, 2000; 165(7): 4024 - 4031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamaki, T. Yonezawa, and K. Ohuchi Signal Transduction Cascade in Staurosporine-Induced Prostaglandin E2 Production by Rat Peritoneal Macrophages J. Pharmacol. Exp. Ther., April 1, 2000; 293(1): 206 - 213. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. E. Rys-Sikora, R. L. Konger, J. W. Schoggins, R. Malaviya, and A. P. Pentland Coordinate expression of secretory phospholipase A2 and cyclooxygenase-2 in activated human keratinocytes Am J Physiol Cell Physiol, April 1, 2000; 278(4): C822 - C833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bezzine, R. S. Koduri, E. Valentin, M. Murakami, I. Kudo, F. Ghomashchi, M. Sadilek, G. Lambeau, and M. H. Gelb Exogenously Added Human Group X Secreted Phospholipase A2 but Not the Group IB, IIA, and V Enzymes Efficiently Release Arachidonic Acid from Adherent Mammalian Cells J. Biol. Chem., February 4, 2000; 275(5): 3179 - 3191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakatani, T. Tanioka, S. Sunaga, M. Murakami, and I. Kudo Identification of a Cellular Protein That Functionally Interacts with the C2 Domain of Cytosolic Phospholipase A2alpha J. Biol. Chem., January 14, 2000; 275(2): 1161 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hanasaki, T. Ono, A. Saiga, Y. Morioka, M. Ikeda, K. Kawamoto, K.-i. Higashino, K. Nakano, K. Yamada, J. Ishizaki, et al. Purified Group X Secretory Phospholipase A2 Induced Prominent Release of Arachidonic Acid from Human Myeloid Leukemia Cells J. Biol. Chem., November 26, 1999; 274(48): 34203 - 34211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, T. Kambe, S. Shimbara, K.-i. Higashino, K. Hanasaki, H. Arita, M. Horiguchi, M. Arita, H. Arai, K. Inoue, et al. Different Functional Aspects of the Group II Subfamily (Types IIA and V) and Type X Secretory Phospholipase A2s in Regulating Arachidonic Acid Release and Prostaglandin Generation. IMPLICATIONS OF CYCLOOXYGENASE-2 INDUCTION AND PHOSPHOLIPID SCRAMBLASE-MEDIATED CELLULAR MEMBRANE PERTURBATION J. Biol. Chem., October 29, 1999; 274(44): 31435 - 31444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. O. Bingham III, R. J. A. Fijneman, D. S. Friend, R. P. Goddeau, R. A. Rogers, K. F. Austen, and J. P. Arm Low Molecular Weight Group IIA and Group V Phospholipase A2 Enzymes Have Different Intracellular Locations in Mouse Bone Marrow-derived Mast Cells J. Biol. Chem., October 29, 1999; 274(44): 31476 - 31484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, T. Kambe, S. Shimbara, S. Yamamoto, H. Kuwata, and I. Kudo Functional Association of Type IIA Secretory Phospholipase A2 with the Glycosylphosphatidylinositol-anchored Heparan Sulfate Proteoglycan in the Cyclooxygenase-2-mediated Delayed Prostanoid-biosynthetic Pathway J. Biol. Chem., October 15, 1999; 274(42): 29927 - 29936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rufini, P. De Vito, N. Balestro, M. Pescatori, P. Luly, and S. Incerpi PLA2 stimulation of Na+/H+ antiport and proliferation in rat aortic smooth muscle cells Am J Physiol Cell Physiol, October 1, 1999; 277(4): C814 - C822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ishizaki, N. Suzuki, K.-i. Higashino, Y. Yokota, T. Ono, K. Kawamoto, N. Fujii, H. Arita, and K. Hanasaki Cloning and Characterization of Novel Mouse and Human Secretory Phospholipase A2s J. Biol. Chem., August 27, 1999; 274(35): 24973 - 24979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shinohara, M. A. Balboa, C. A. Johnson, J. Balsinde, and E. A. Dennis Regulation of Delayed Prostaglandin Production in Activated P388D1 Macrophages by Group IV Cytosolic and Group V Secretory Phospholipase A2s J. Biol. Chem., April 30, 1999; 274(18): 12263 - 12268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fujishima, R. O. Sanchez Mejia, C. O. Bingham III, B. K. Lam, A. Sapirstein, J. V. Bonventre, K. F. Austen, and J. P. Arm Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells PNAS, April 27, 1999; 96(9): 4803 - 4807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Beasley COX-2 and cytosolic PLA2 mediate IL-1beta -induced cAMP production in human vascular smooth muscle cells Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1369 - H1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, T. Kambe, S. Shimbara, and I. Kudo Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways J. Biol. Chem., January 29, 1999; 274(5): 3103 - 3115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sartipy, G. Bondjers, and E. Hurt-Camejo Phospholipase A2 Type II Binds to Extracellular Matrix Biglycan : Modulation of Its Activity on LDL by Colocalization in Glycosaminoglycan Matrixes Arterioscler. Thromb. Vasc. Biol., December 1, 1998; 18(12): 1934 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Koduri, S. F. Baker, Y. Snitko, S. K. Han, W. Cho, D. C. Wilton, and M. H. Gelb Action of Human Group IIa Secreted Phospholipase A2 on Cell Membranes. VESICLE BUT NOT HEPARINOID BINDING DETERMINES RATE OF FATTY ACID RELEASE BY EXOGENOUSLY ADDED ENZYME J. Biol. Chem., November 27, 1998; 273(48): 32142 - 32153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Surette, N. Dallaire, N. Jean, S. Picard, and P. Borgeat Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptide-stimulated human neutrophils FASEB J, November 1, 1998; 12(14): 1521 - 1531. [Abstract] [Full Text]
|
|
|
|
|
|
K. Tada, M. Murakami, T. Kambe, and I. Kudo Induction of Cyclooxygenase-2 by Secretory Phospholipases A2 in Nerve Growth Factor-Stimulated Rat Serosal Mast Cells Is Facilitated by Interaction with Fibroblasts and Mediated by a Mechanism Independent of Their Enzymatic Functions J. Immunol., November 1, 1998; 161(9): 5008 - 5015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. S Jamal, P. G Conaghan, A. M Cunningham, P. M Brooks, V. F Munro, and K. F Scott Increased expression of human type IIa secretory phospholipase A2 antigen in arthritic synovium Ann Rheum Dis, September 1, 1998; 57(9): 550 - 558. [Abstract] [Full Text]
|
|
|
|
|
|
J. Balsinde, M. A. Balboa, and E. A. Dennis Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2 PNAS, July 7, 1998; 95(14): 7951 - 7956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, S. Shimbara, T. Kambe, H. Kuwata, M. V. Winstead, J. A. Tischfield, and I. Kudo The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release. TYPE IIA AND TYPE V SECRETORY PHOSPHOLIPASE A2S ARE FUNCTIONALLY REDUNDANT AND ACT IN CONCERT WITH CYTOSOLIC PHOSPHOLIPASE A2 J. Biol. Chem., June 5, 1998; 273(23): 14411 - 14423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-i. Atsumi, M. Tajima, A. Hadano, Y. Nakatani, M. Murakami, and I. Kudo Fas-induced Arachidonic Acid Release Is Mediated by Ca2+-independent Phospholipase A2 but Not Cytosolic Phospholipase A2, Which Undergoes Proteolytic Inactivation J. Biol. Chem., May 29, 1998; 273(22): 13870 - 13877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Spencer, J. W. Woods, T. Arakawa, I. I. Singer, and W. L. Smith Subcellular Localization of Prostaglandin Endoperoxide H Synthases-1 and -2 by Immunoelectron Microscopy J. Biol. Chem., April 17, 1998; 273(16): 9886 - 9893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Naraba, M. Murakami, H. Matsumoto, S. Shimbara, A. Ueno, I. Kudo, and S. Oh-ishi Segregated Coupling of Phospholipases A2, Cyclooxygenases, and Terminal Prostanoid Synthases in Different Phases of Prostanoid Biosynthesis in Rat Peritoneal Macrophages J. Immunol., March 15, 1998; 160(6): 2974 - 2982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kuwata, Y. Nakatani, M. Murakami, and I. Kudo Cytosolic Phospholipase A2 Is Required for Cytokine-induced Expression of Type IIA Secretory Phospholipase A2 That Mediates Optimal Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Rat 3Y1 Fibroblasts J. Biol. Chem., January 16, 1998; 273(3): 1733 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hernandez, S. L. Burillo, M. S. Crespo, and M. L. Nieto Secretory Phospholipase A2 Activates the Cascade of Mitogen-activated Protein Kinases and Cytosolic Phospholipase A2 in the Human Astrocytoma Cell Line 1321N1 J. Biol. Chem., January 2, 1998; 273(1): 606 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Nakajima, M. Murakami, R. Yanoshita, Y. Samejima, K. Karasawa, M. Setaka, S. Nojima, and I. Kudo Activated Mast Cells Release Extracellular Type Platelet-activating Factor Acetylhydrolase That Contributes to Autocrine Inactivation of Platelet-activating Factor J. Biol. Chem., August 8, 1997; 272(32): 19708 - 19713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, H. Kuwata, Y. Amakasu, S. Shimbara, Y. Nakatani, G.-i. Atsumi, and I. Kudo Prostaglandin E2 Amplifies Cytosolic Phospholipase A2- and Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Mouse Osteoblastic Cells. ENHANCEMENT BY SECRETORY PHOSPHOLIPASE A2 J. Biol. Chem., August 8, 1997; 272(32): 19891 - 19897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-i. Atsumi, M. Murakami, K. Kojima, A. Hadano, M. Tajima, and I. Kudo Distinct Roles of Two Intracellular Phospholipase A2s in Fatty Acid Release in the Cell Death Pathway. PROTEOLYTIC FRAGMENT OF TYPE IVA CYTOSOLIC PHOSPHOLIPASE A2alpha INHIBITS STIMULUS-INDUCED ARACHIDONATE RELEASE, WHEREAS THAT OF TYPE VI Ca2+-INDEPENDENT PHOSPHOLIPASE A2 AUGMENTS SPONTANEOUS FATTY ACID RELEASE J. Biol. Chem., June 9, 2000; 275(24): 18248 - 18258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tanioka, Y. Nakatani, N. Semmyo, M. Murakami, and I. Kudo Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2 Biosynthesis J. Biol. Chem., October 13, 2000; 275(42): 32775 - 32782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, H. Naraba, T. Tanioka, N. Semmyo, Y. Nakatani, F. Kojima, T. Ikeda, M. Fueki, A. Ueno, S. Oh-ishi, et al. Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2 J. Biol. Chem., October 13, 2000; 275(42): 32783 - 32792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Kim, J. D. Rafter, L. Bittova, S. K. Han, Y. Snitko, N. M. Munoz, A. R. Leff, and W. Cho Mechanism of Human Group V Phospholipase A2 (PLA2)-induced Leukotriene Biosynthesis in Human Neutrophils. A POTENTIAL ROLE OF HEPARAN SULFATE BINDING IN PLA2 INTERNALIZATION AND DEGRADATION J. Biol. Chem., March 30, 2001; 276(14): 11126 - 11134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Ribardo, S. E. Crowe, K. R. Kuhl, J. W. Peterson, and A. K. Chopra Prostaglandin Levels in Stimulated Macrophages Are Controlled by Phospholipase A2-activating Protein and by Activation of Phospholipase C and D J. Biol. Chem., February 16, 2001; 276(8): 5467 - 5475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, R. S. Koduri, A. Enomoto, S. Shimbara, M. Seki, K. Yoshihara, A. Singer, E. Valentin, F. Ghomashchi, G. Lambeau, et al. Distinct Arachidonate-releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 and Rat Mastocytoma RBL-2H3 Cells through Heparan Sulfate Shuttling and External Plasma Membrane Mechanisms J. Biol. Chem., March 23, 2001; 276(13): 10083 - 10096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ueno, M. Murakami, T. Tanioka, K. Fujimori, T. Tanabe, Y. Urade, and I. Kudo Coupling between Cyclooxygenase, Terminal Prostanoid Synthase, and Phospholipase A2 J. Biol. Chem., September 7, 2001; 276(37): 34918 - 34927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hosono, J. Aoki, Y. Nagai, K. Bandoh, M. Ishida, R. Taguchi, H. Arai, and K. Inoue Phosphatidylserine-specific Phospholipase A1 Stimulates Histamine Release from Rat Peritoneal Mast Cells through Production of 2-Acyl-1-lysophosphatidylserine J. Biol. Chem., August 3, 2001; 276(32): 29664 - 29670. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
