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Volume 271, Number 48, Issue of November 29, 1996 pp. 30916-30921
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

Expression of the Protein Tyrosine Phosphatase beta 2 Gene in Mouse Erythroleukemia Cells Induces Terminal Erythroid Differentiation

(Received for publication, July 10, 1996, and in revised form, September 11, 1996)

Tsutomu Kume Dagger , Toshio Watanabe Dagger § , Reiko Sanokawo , Dai Chida Dagger , Takeshi Nakamura and Michio Oishi Dagger par

From the Dagger  Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku 113, Tokyo, Japan, the § Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980, Japan, the  Biomedical Research and Development Department, Sumitomo Electric Industries, Sakae-ku, Yokohama 244, Japan, and the par  National Institute of Bioscience and Human Technology, Tsukuba, Ibaraki 305, Japan

We have cloned cDNA for protein tyrosine phosphatase beta 2, which had been implicated in erythroid differentiation of mouse erythroleukemia cells. Expression of cDNA constructs, in which beta 2 cDNA is placed under the control of mouse metallothionein-I promoter, by ZnCl2 converted a significant portion (20 to 38%) of the cells to erythroid-like cells, which is 25-50% of the erythroid differentiation efficiency observed by conventional erythroid-inducing agents. Furthermore, introduction and expression of altered protein tyrosine phosphatase beta 2 cDNA constructs designed to produce the enzyme lacking the phosphatase activity inhibited erythroid differentiation by 100-20%, depending upon the concentration of erythroid-inducing agents employed. These results strongly suggest that protein tyrosine phosphatase beta 2 is involved in triggering erythroid differentiation in mouse erythroleukemia cells.


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