| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, August 5, 1996, and in revised form, October 2, 1996)
From the A plasma membrane iron reductase, required for
cellular iron acquisition by Saccharomyces cerevisiae, and
the human phagocytic NADPH oxidase, implicated in cellular defense,
contain low potential plasma membrane b cytochromes that
share elements of structure and function. Four critical histidine
residues in the FRE1 protein of the iron reductase were identified by
site-directed mutagenesis. Individual mutation of each histidine to
alanine eliminated the entire heme spectrum without affecting
expression of the apoprotein, documenting the specificity of the
requirement for the histidine residues. These critical residues are
predicted to coordinate a bis-heme structure between transmembrane
domains of the FRE1 protein. The histidine residues are conserved in
the related gp91phox protein of the NADPH oxidase of human
granulocytes, predicting the sites of heme coordination in that protein
complex. Similarly spaced histidine residues have also been implicated
in heme binding by organelle b cytochromes with little
overall sequence similarity to the plasma membrane b
cytochromes. This bis-heme motif may play a role in transmembrane
electron transport by distinct families of polytopic b
cytochromes.
Volume 271, Number 49,
Issue of December 6, 1996
pp. 31021-31024
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
COMMUNICATION:
,
and
Cell Biology and Metabolism Branch, NICHD,
National Institutes of Health, Bethesda, Maryland 20892 and the
¶ Department of Medicine, University College London Medical
School, London, WC1E 6JJ, United Kingdom
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  W. M. Nauseef Biological Roles for the NOX Family NADPH Oxidases J. Biol. Chem., June 20, 2008; 283(25): 16961 - 16965. [Full Text] [PDF]
|
|
|
|
 |
|
 O. Protchenko, M. Shakoury-Elizeh, P. Keane, J. Storey, R. Androphy, and C. C. Philpott Role of PUG1 in Inducible Porphyrin and Heme Transport in Saccharomyces cerevisiae Eukaryot. Cell, May 1, 2008; 7(5): 859 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Allen, J. A. del Campo, J. Kropat, and S. S. Merchant FEA1, FEA2, and FRE1, Encoding Two Homologous Secreted Proteins and a Candidate Ferrireductase, Are Expressed Coordinately with FOX1 and FTR1 in Iron-Deficient Chlamydomonas reinhardtii Eukaryot. Cell, October 1, 2007; 6(10): 1841 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miethke and M. A. Marahiel Siderophore-Based Iron Acquisition and Pathogen Control Microbiol. Mol. Biol. Rev., September 1, 2007; 71(3): 413 - 451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bedard and K.-H. Krause The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology Physiol Rev, January 1, 2007; 87(1): 245 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Li and B. Frei Iron Chelation Inhibits NF-{kappa}B-Mediated Adhesion Molecule Expression by Inhibiting p22phox Protein Expression and NADPH Oxidase Activity Arterioscler. Thromb. Vasc. Biol., December 1, 2006; 26(12): 2638 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. B. Knight and A. Dancis Reduction of 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide inner salt (XTT) is dependent on CaFRE10 ferric reductase for Candida albicans grown in unbuffered media. Microbiology, August 1, 2006; 152(Pt 8): 2301 - 2308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tanaka, M. J. Christensen, D. Takemoto, P. Park, and B. Scott Reactive Oxygen Species Play a Role in Regulating a Fungus-Perennial Ryegrass Mutualistic Interaction PLANT CELL, April 1, 2006; 18(4): 1052 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. B. Knight, G. Vilaire, E. Lesuisse, and A. Dancis Iron Acquisition from Transferrin by Candida albicans Depends on the Reductive Pathway Infect. Immun., September 1, 2005; 73(9): 5482 - 5492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Ramalho, S. Paiva, A. Cavaco-Paulo, M. Casal, M. H. Cardoso, and M. T. Ramalho Azo Reductase Activity of Intact Saccharomyces cerevisiae Cells Is Dependent on the Fre1p Component of Plasma Membrane Ferric Reductase Appl. Envir. Microbiol., July 1, 2005; 71(7): 3882 - 3888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nishida, L. S. Yoshida, T. Shimoyama, H. Nunoi, T. Kobayashi, and S. Tsunawaki Fungal Metabolite Gliotoxin Targets Flavocytochrome b558 in the Activation of the Human Neutrophil NADPH Oxidase Infect. Immun., January 1, 2005; 73(1): 235 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Abraham, R. Rezzani, L. Rodella, A. Kruger, D. Taller, G. Li Volti, A. I. Goodman, and A. Kappas Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2468 - H2477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Quinn and K. A. Gauss Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases J. Leukoc. Biol., October 1, 2004; 76(4): 760 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. De Freitas, J. H. Kim, H. Poynton, T. Su, H. Wintz, T. Fox, P. Holman, A. Loguinov, S. Keles, M. van der Laan, et al. Exploratory and Confirmatory Gene Expression Profiling of mac1{Delta} J. Biol. Chem., February 6, 2004; 279(6): 4450 - 4458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yoshioka, N. Numata, K. Nakajima, S. Katou, K. Kawakita, O. Rowland, J. D. G. Jones, and N. Doke Nicotiana benthamiana gp91phox Homologs NbrbohA and NbrbohB Participate in H2O2 Accumulation and Resistance to Phytophthora infestans PLANT CELL, March 1, 2003; 15(3): 706 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oberegger, M. Schoeser, I. Zadra, M. Schrettl, W. Parson, and H. Haas Regulation of freA, acoA, lysF, and cycA Expression by Iron Availability in Aspergillus nidulans Appl. Envir. Microbiol., November 1, 2002; 68(11): 5769 - 5772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. B. Knight, E. Lesuisse, R. Stearman, R. D. Klausner, and A. Dancis Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator Microbiology, January 1, 2002; 148(1): 29 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Foubert, J. B. Bleazard, J. B. Burritt, J. M. Gripentrog, D. Baniulis, R. M. Taylor, and A. J. Jesaitis Identification of a Spectrally Stable Proteolytic Fragment of Human Neutrophil Flavocytochrome b Composed of the NH2-terminal Regions of gp91phox and p22phox J. Biol. Chem., October 12, 2001; 276(42): 38852 - 38861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Geiszt, J. B. Kopp, P. Várnai, and T. L. Leto Identification of Renox, an NAD(P)H oxidase in kidney PNAS, June 23, 2000; (2000) 130135897. [Abstract] [Full Text]
|
|
|
|
|
|
J. E. Hammacott, P. H. Williams, and A. M. Cashmore Candida albicans CFL1 encodes a functional ferric reductase activity that can rescue a Saccharomyces cerevisiae fre1 mutant Microbiology, April 1, 2000; 146(4): 869 - 876. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. H. W. Leusen, C. Meischl, M. H. M. Eppink, P. M. Hilarius, M. de Boer, R. S. Weening, A. Ahlin, L. Sanders, D. Goldblatt, H. Skopczynska, et al. Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly Blood, January 15, 2000; 95(2): 666 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhu, H. Qiu, H.-W. P. Yoon, S. Huang, and H. F. Bunn Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells PNAS, December 21, 1999; 96(26): 14742 - 14747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kaneda, H. Sakuraba, A. Ohtake, A. Nishida, C. Kiryu, and K. Kakinuma Missense Mutations in the gp91-phox Gene Encoding Cytochrome b558 in Patients With Cytochrome b Positive and Negative X-Linked Chronic Granulomatous Disease Blood, March 15, 1999; 93(6): 2098 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Babior NADPH Oxidase: An Update Blood, March 1, 1999; 93(5): 1464 - 1476. [Full Text] [PDF]
|
|
|
|
|
|
L. S. Yoshida, F. Saruta, K. Yoshikawa, O. Tatsuzawa, and S. Tsunawaki Mutation at Histidine 338 of gp91phox Depletes FAD and Affects Expression of Cytochrome b558 of the Human NADPH Oxidase J. Biol. Chem., October 23, 1998; 273(43): 27879 - 27886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Martins, L. T. Jensen, J. R. Simon, G. L. Keller, and D. R. Winge Metalloregulation of FRE1 and FRE2 Homologs in Saccharomyces cerevisiae J. Biol. Chem., September 11, 1998; 273(37): 23716 - 23721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yu, M. T. Quinn, A. R. Cross, and M. C. Dinauer Gp91phox is the heme binding subunit of the superoxide-generating NADPH oxidase PNAS, July 7, 1998; 95(14): 7993 - 7998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Keller, H. G. Damude, D. Werner, P. Doerner, R. A. Dixon, and C. Lamb A Plant Homolog of the Neutrophil NADPH Oxidase gp91phox Subunit Gene Encodes a Plasma Membrane Protein with Ca2+ Binding Motifs PLANT CELL, February 1, 1998; 10(2): 255 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yu, L. Zhen, and M. C. Dinauer Biosynthesis of the Phagocyte NADPH Oxidase Cytochrome b558. ROLE OF HEME INCORPORATION AND HETERODIMER FORMATION IN MATURATION AND STABILITY OF gp91phox and p22phox SUBUNITS J. Biol. Chem., October 24, 1997; 272(43): 27288 - 27294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-W. Yun, M. Bauler, R. E. Moore, P. E. Klebba, and C. C. Philpott The Role of the FRE Family of Plasma Membrane Reductases in the Uptake of Siderophore-Iron in Saccharomyces cerevisiae J. Biol. Chem., March 23, 2001; 276(13): 10218 - 10223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Banfi, G. Molnar, A. Maturana, K. Steger, B. Hegedus, N. Demaurex, and K.-H. Krause A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes J. Biol. Chem., September 28, 2001; 276(40): 37594 - 37601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Biberstine-Kinkade, F. R. DeLeo, R. I. Epstein, B. A. LeRoy, W. M. Nauseef, and M. C. Dinauer Heme-ligating Histidines in Flavocytochrome b558. IDENTIFICATION OF SPECIFIC HISTIDINES IN gp91phox J. Biol. Chem., August 10, 2001; 276(33): 31105 - 31112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Narahari, R. Ma, M. Wang, and W. E. Walden The Aconitase Function of Iron Regulatory Protein 1. GENETIC STUDIES IN YEAST IMPLICATE ITS ROLE IN IRON-MEDIATED REDOX REGULATION J. Biol. Chem., May 19, 2000; 275(21): 16227 - 16234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Geiszt, J. B. Kopp, P. Varnai, and T. L. Leto Identification of Renox, an NAD(P)H oxidase in kidney PNAS, July 5, 2000; 97(14): 8010 - 8014. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
