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Volume 271, Number 49, Issue of December 6, 1996 pp. 31115-31120
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.

Regulation of Nerve Growth Factor mRNA by Interleukin-1 in Rat Hippocampal Astrocytes Is Mediated by NFkappa B

(Received for publication, August 23, 1996)

Wilma J. Friedman Dagger , Sanjay Thakur , Lisa Seidman par and Arnold B. Rabson par

From the Departments of Dagger  Neuroscience and Cell Biology and par  Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School and  Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854

Cytokines such as interleukin-1beta (Il-1) are produced in the brain during development and during inflammatory processes that result from lesions or disease. One function of Il-1 in the brain appears to be the stimulation of astrocytes to proliferate and produce a variety of cytokines and trophic factors, including nerve growth factor. The mechanisms by which Il-1 exerts its actions on astrocytes remain poorly defined. We present evidence that this cytokine elicits activation of the NFkappa B transcription factor and that this transcription factor mediates effects of Il-1 on nerve growth factor mRNA expression. Elucidation of the processes by which cytokines activate astrocytes and influence trophic factor expression may provide insight into mechanisms governing inflammatory processes within the central nervous system.


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