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(Received for publication, August 14, 1996)
From the We have identified a novel zinc-finger protein
whose mRNA is expressed at high levels in the epidermal layer of
the skin and in epithelial cells in the tongue, palate, esophagus,
stomach, and colon of newborn mice. Expression in epithelial cells is
first detected at the time of their differentiation during embryonic development. In addition, during early embryonic development there is
expression in mesenchymal cells of the skeletal primordia and the
metanephric kidney which is later down-regulated. The expression pattern suggests that the protein could be involved in terminal differentiation of several epithelial cell types and could also be
involved in early differentiation of the skeleton and kidney. The
carboxyl terminus of the protein contains three zinc fingers with a
high degree of homology to erythroid krüppel-like factor and
binds to DNA fragments containing CACCC motifs. The amino-terminal portion of the protein is proline and serine-rich and can function as a
transcriptional activator. The chromosomal location of the gene was
mapped using mouse interspecific backcrosses and was shown to localize
to mouse chromosome 4 and to cosegregate with the thioredoxin gene.
Volume 271, Number 49,
Issue of December 6, 1996
pp. 31384-31390
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
,
,
Department of Molecular Genetics, The
University of Texas M. D. Anderson Cancer Center, Houston, Texas
77030 and the § Departments of Medicine and
Microbiology, Duke University Medical Center,
Durham, North Carolina 27710
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S.-F. Yet, M. M. McA'Nulty, S. C. Folta, H.-W. Yen, M. Yoshizumi, C.-M. Hsieh, M. D. Layne, M. T. Chin, H. Wang, M. A. Perrella, et al. Human EZF, a Kruppel-like Zinc Finger Protein, Is Expressed in Vascular Endothelial Cells and Contains Transcriptional Activation and Repression Domains J. Biol. Chem., January 9, 1998; 273(2): 1026 - 1031. [Abstract] [Full Text] [PDF]
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J. M. Shields and V. W. Yang Two Potent Nuclear Localization Signals in the Gut-enriched Kruppel-like Factor Define a Subfamily of Closely Related Kruppel Proteins J. Biol. Chem., July 18, 1997; 272(29): 18504 - 18507. [Abstract] [Full Text] [PDF]
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