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(Received for publication, November 6, 1995; and in revised form, December 13, 1995) The mitogen-activated protein kinase (MAPK) family is comprised
of key regulatory proteins that control the cellular response to both
proliferation and stress signals. In this study we investigated the
factors controlling MAPK activation by H
Volume 271,
Number 8,
Issue of February 23, 1996 pp. 4138-4142
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
O
ROLE IN CELL SURVIVAL FOLLOWING OXIDANT INJURY
O and
explored the impact of altering the pathways to kinase activation on
cell survival following HO exposure. Potent
activation (10-20-fold) of extracellular signal-regulated protein
kinase (ERK2) occurred within 10 min of HO treatment, whereupon rapid inactivation ensued.
HO activated ERK2 in several cell types and
also moderately activated (3-5-fold) both c-Jun N-terminal kinase
and p38/RK/CSBP. Additionally, HO increased the
mRNA expression of MAPK-dependent genes c-jun, c-fos,
and MAPK phosphatase-1. Suramin pretreatment completely inhibited
HO stimulation of ERK2, highlighting a role for
growth factor receptors in this activation. Further, ERK2 activation by
HO was blocked by pretreatment with either N-acetyl-cysteine, o-phenanthroline, or mannitol,
indicating that metal-catalyzed free radical formation mediates the
initiation of signal transduction by HO.
HO-stimulated activation of ERK2 was abolished
in PC12 cells by inducible or constitutive expression of the dominant
negative Ras-N-17 allele. Interestingly, PC12/Ras-N-17 cells were more
sensitive than wild-type PC12 cells to HO toxicity. Moreover, NIH 3T3 cells expressing constitutively
active MAPK kinase (MEK, the immediate upstream regulator of ERK) were
more resistant to HO toxicity, while those
expressing kinase-defective MEK were more sensitive, than cells
expressing wild-type MEK. Taken together, these studies provide insight
into mechanisms of MAPK regulation by HO and
suggest that ERK plays a critical role in cell survival following
oxidant injury.
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|
|
|
 |
|
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|
|
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|
|
|
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|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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